Difference between revisions of "Team:TU Darmstadt"

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    <h2> iGEM TU Darmstadt 2016</h2>
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     <h3>Glow before you go (working title)</h3>
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     <h4>Project description</h4>
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        The critical evaluation of the project’s safety is required from each iGEM Team participating in the competition. Therefore the iGEM HQ created an entire subpage on their website where the teams can find all the necessary information, such as risk levels or general safety requirements. Unfortunately there is no chance to look up complete, working safety approaches from previous teams.
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            It should be easy for teams to choose a well characterized safety approach which is suitable for their own project out of a catalog and directly see how to easily incorporate it. Our project is supposed to lead the way into that direction.  
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        In our 2016 project we focus on easily enabling teams to work safely with <i>E.coli</i>. By integrating genetic circuits into the <i>E.coli</i> genome we ensure that genetically modified bacteria cannot survive outside of the required lab with the particular conditions they need. The genetic circuit is based on the availability of an unnatural amino acid (UAA) and is regulated within two steps:<br>
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            <li>When the concentration of the unnatural amino acid is low a reporter protein is expressed which signalizes the low level of UAA.</li>
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            <li>When the UAA concentration reaches zero (which is also the case if bacteria get out of the lab) the expression of colicin is induced which then kills the bacteria.</li><br>
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        Additionally we hope to facilitate and accelerate the molecular cloning process of DNA through a new standard based on the RFC10 standard. We use riboswitches to show a successful ligation without additional testing procedures.<br>
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     <h3>Project brainstorming</h3>
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        Like every year we started our weekly team meetings in january and thought about possible projects. This year it took us a bit longer to find a project but around the end of march we were closing in on a safety project around colicin. By mid march we had our project overview and started dividing into several lab groups that focused on their individual pathways.
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        By now the first cloning procedures have been succesful and we are looking forward to conduct first measurements.
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         <!-- header -->
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  <ul id="slick-menu">
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    <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Achievements">Achievements</a></li>
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     <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Lab" class="current">In the Lab</a></li>
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    <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Parts">Parts</a></li>
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     <li><a href="#">Results</a></li>            
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    <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Hardware">Robotics</a></li>
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    <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Model">Modeling</a></li>
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     <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Human_Practices">Human Practices</a></li>
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     <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Collaborations">Collaborations</a></li>
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     <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Notebook">Notebook</a></li>
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     <li><a href="https://2016.igem.org/Team:TU_Darmstadt/Team">Team</a></li>
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<h2 style="color: #FFF; text-shadow: -1px 0 black, 0 1px black, 1px 0 black, 0 -1px black;">Colicide Squad</h2>
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<p style="color: #FFF; font-weight: bold; text-shadow: -1px 0 black, 0 1px black, 1px 0 black, 0 -1px black;">Glow<br />
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  before you<br />
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    go.</p>
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            </div>
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<a href="#one" class="more scrolly">learn more</a>
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        </section>
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                <header class="major">
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                    <h2>This page is dedicated to the project<br />
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                        of iGEM Technische Universität Darmstadt 2016</h2>
 +
<p>Aliquam ut ex ut augue consectetur interdum. Donec amet imperdiet eleifend<br />
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fringilla tincidunt. Nullam dui leo Aenean mi ligula, rhoncus ullamcorper.</p>
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    <section class="spotlight">
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                <div class="image"><img src="images/Laboratory.png" alt="" /></div><div class="content">
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    <h2>metabolic<br />
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Engineering</h2>
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                    <p>Work in the laboratory and achievements can be found <a href="http://google.com">here</a></p>
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</div>
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            </section>
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            <section class="spotlight">
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                <div class="image"><img src="images/lambdaCapsid.jpg" alt="" /></div><div class="content">
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    <h2>Modeling</h2>
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                    <h2>
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                        <p>This page is dedicated to the project<br />
 +
                        of iGEM Technische Universität Darmstadt 2016</h2>
 +
<p>Bonding between Colicin E2 and its immunity protein depends highly on structural properties. Changing the amino acid sequence of Colicin E2's immunity protein can therefore take strong influence in it's effecitveness.<br/>
 +
Hence we tried to approximate the influence of our noncanonical amino acid in the immunity protein. We achieved this by applying molecular dynamics simualtions to explore relevant configurations and free energie calcualtions to compare the bonding properties of our mutation variants. We also developed an extended CHARMm force field for our noncanonical amino acid <i>O</i>-methyl tyrosine.<a href="http://google.com">here</a></p>
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                </div>
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            </section>
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            <section class="spotlight">
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                <div class="image"><img src="images/maxresdefault.jpg" alt="" /></div><div class="content">
 +
                    <h2>Human Practices</h2>
 +
                    <p>All our work with human beings can be found <a href="http://google.com">here</a></p>
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                </div>
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            </section>
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</section>
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        <!-- CTA -->
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<section id="cta" class="wrapper style4">
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<div class="inner">
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<header>
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<h2>Thank you!</h2>
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<p>For your interest in our project<br />
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                                Sincerely, the team
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                                </p>
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<li><a href="#" class="button fit">Impressum</a></li>
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Revision as of 18:39, 13 October 2016

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iGEM - Darmstadt
menu

This page is dedicated to the project
of iGEM Technische Universität Darmstadt 2016

Aliquam ut ex ut augue consectetur interdum. Donec amet imperdiet eleifend
fringilla tincidunt. Nullam dui leo Aenean mi ligula, rhoncus ullamcorper.

metabolic
Engineering

Work in the laboratory and achievements can be found here

Modeling

This page is dedicated to the project
of iGEM Technische Universität Darmstadt 2016

Bonding between Colicin E2 and its immunity protein depends highly on structural properties. Changing the amino acid sequence of Colicin E2's immunity protein can therefore take strong influence in it's effecitveness.
Hence we tried to approximate the influence of our noncanonical amino acid in the immunity protein. We achieved this by applying molecular dynamics simualtions to explore relevant configurations and free energie calcualtions to compare the bonding properties of our mutation variants. We also developed an extended CHARMm force field for our noncanonical amino acid O-methyl tyrosine.here

Human Practices

All our work with human beings can be found here

Thank you!

For your interest in our project
Sincerely, the team