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<p>Welcome to the University of Manchester’s iGEM 2016 Wiki page! We are a team of 11 undergraduate students all studying at the University of Manchester based in the Manchester Institute of Biotechnology under the supervision of Professor Rainer Breitling and Professor Eriko Takano.</p> | <p>Welcome to the University of Manchester’s iGEM 2016 Wiki page! We are a team of 11 undergraduate students all studying at the University of Manchester based in the Manchester Institute of Biotechnology under the supervision of Professor Rainer Breitling and Professor Eriko Takano.</p> | ||
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| − | Controlling alcohol consumption can be difficult, especially amongst students in the UK. An alcohol patch that generates a visible colour change according to blood alcohol concentration could be used to monitor the level of intoxication in a person. Having an indicator to show how intoxicated a person is could help reduce undesired consequences of being too drunk | + | <h4>Science Behind AlcoPatch</h4> |
| − | < | + | <p>Controlling alcohol consumption can be difficult, especially amongst students in the UK. An alcohol patch that generates a visible colour change according to blood alcohol concentration could be used to monitor the level of intoxication in a person. Having an indicator to show how intoxicated a person is could help reduce undesired consequences of being too drunk </p> |
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| − | <p> | + | <h4>Our Project Plan </h4> |
| − | We will be updating the Wiki with much more information as we progress through the project so check back often!</p> | + | <p>It is known that the ethanol concentration in sweat is linearly related to the blood alcohol concentration. Based on this, we aim to develop an ethanol biosensor by using synthetic biology with two separate methods to measure intoxication levels. The first mechanism involves the usage of alcohol oxidase (AOX) in a cell-free system to oxidise ethanol to acetaldehyde that produces hydrogen peroxide ($H_2O_2$) as a by-product. $H_2O_2$ is used as an oxidising agent by horseradish peroxidase (HRP) to convert ABTS to produce luminescence. The second mechanism involves activation of ethanol sensitive alcR in engineered Escherichia Coli (E.Coli). The activated transcription factor then activates the promoter alcA leading to the expression of chromoprotein. |
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| + | <p>We will be updating the Wiki with much more information as we progress through the project so check back often!</p> | ||
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We can be contacted at: | We can be contacted at: | ||
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<a href="https://www.facebook.com/uomigem2016" target="_blank" > Facebook </a> | <a href="https://www.facebook.com/uomigem2016" target="_blank" > Facebook </a> | ||
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<a href="https://twitter.com/igemManc" target="_blank" > Twitter </a> | <a href="https://twitter.com/igemManc" target="_blank" > Twitter </a> | ||
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Revision as of 15:38, 28 June 2016
Welcome to iGEM 2016!
Welcome to the University of Manchester’s iGEM 2016 Wiki page! We are a team of 11 undergraduate students all studying at the University of Manchester based in the Manchester Institute of Biotechnology under the supervision of Professor Rainer Breitling and Professor Eriko Takano.
Science Behind AlcoPatch
Controlling alcohol consumption can be difficult, especially amongst students in the UK. An alcohol patch that generates a visible colour change according to blood alcohol concentration could be used to monitor the level of intoxication in a person. Having an indicator to show how intoxicated a person is could help reduce undesired consequences of being too drunk
Our Project Plan
It is known that the ethanol concentration in sweat is linearly related to the blood alcohol concentration. Based on this, we aim to develop an ethanol biosensor by using synthetic biology with two separate methods to measure intoxication levels. The first mechanism involves the usage of alcohol oxidase (AOX) in a cell-free system to oxidise ethanol to acetaldehyde that produces hydrogen peroxide ($H_2O_2$) as a by-product. $H_2O_2$ is used as an oxidising agent by horseradish peroxidase (HRP) to convert ABTS to produce luminescence. The second mechanism involves activation of ethanol sensitive alcR in engineered Escherichia Coli (E.Coli). The activated transcription factor then activates the promoter alcA leading to the expression of chromoprotein.
We will be updating the Wiki with much more information as we progress through the project so check back often!
Before you start:
Please read the following pages:
Styling your wiki
You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.
While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.
Wiki template information
We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2016 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples:
Uploading pictures and files
You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to Team:YourOfficialTeamName/NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
