Difference between revisions of "Team:NKU China/Description"

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<h5>References</h5>
 
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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<li>Thompson J A, Oliveira R A, Djukovic A, et al. Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota[J]. Cell reports, 2015, 10(11): 1861-1871.</li>
  
 
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Revision as of 16:21, 30 June 2016

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Controller based on Quorum Sensing System to manipulate cell-cell communication and population behaviors

What do we do in this summer?

  • This summer we investigated a kind of quorum sensing molecular, AI-2(autoinducer-2). In our project we try to construct the bacteria machine called Ai-2 Controller which can produce or degrade AI-2 according to the environment and induction conditions. With the important role of AI-2 in population behavior such as biofilm formation, bioluminescence, virulence and antibiotic resistance, AI-2 Controller has its great applications in the fields of fermentation production, reducing antibiotic resistance, improve intestinal microflora environment and so on.

What are the characteristics of AI-2 Controller?

No Side Effect？

No waste to the fermentation environment

AI-2 Consumer & Supplier？

Modulate the external AI-2 environment & attenuating cell–cell communication

Biosafety？

No overgrowth in the fermentation environment & outside the lab

Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.

References
  • Thompson J A, Oliveira R A, Djukovic A, et al. Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota[J]. Cell reports, 2015, 10(11): 1861-1871.