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Revision as of 20:21, 16 October 2016

iGEM Oxford 2016 - Cure for Copper

Achievements
  • Using synthetic biology, our team have designed a way to treat Wilson’s Disease as an alternative to current treatments, which have problems associated with their cost and side-effects.
  • During our project we added 13 new BioBrick parts to the iGEM registry. Check our parts page for more information.
  • We investigated several different promoters five different promoter and two different copper chelators with the aim of finding the most effective system.
  • We successfully designed composite parts with a copper chelator under control of a copper-sensitive promoter. pCopA MymT sfGFP with constitutively expressed CueR works as expected. Check out our results page for more information.
  • Discussions with the wider community played a major role in our project. We spoke to doctors and patients about Wilson’s Disease and used their feedback to guide our project. Check out our integrated human practises page for more information.

Bronze

Register for iGEM, have a great summer, and attend the Giant Jamboree.

We’re ready for Boston in every way after the summer of our lives. Counting down the days to the Giant Jamboree! Our team is registered here: https://igem.org/Team_List.cgi?year=2016


Meet all deliverables on the Requirements page

All submitted with love and hard work. Our judging form is here.


Create a page on your team wiki with clear attribution of each aspect of your project.

We have many to thank and you can find out about them here.


Document at least one new standard BioBrick Part or Device central to your project and submit this part to the iGEM Registry.

TAT Csp1 and TAT Csp1 sfGFP both are new to the registry. You can find them here.

Silver

Experimentally validate that at least one new BioBrick Part or Device of your own design and construction works as expected.

pCopA MymT sfGFP with constitutively expressed CueR works as expected. Our team performed flow cytometry, plate reader experiments and microscopy studies on this part, all of which can be found here.


Convince the judges you have helped any registered iGEM team from high school, a different track, another university, or another institution in a significant way.

We carried out a joint survey with Vilnius-Lithuania iGEM team and created models for their project. We sent Cardiff iGEM 3 of our parts which they very kindly studied using a fluorescence lifetime microscope. You can find out more about our collaborations here.


Demonstrate how your team has identified, investigated and addressed one or more questions relating to human practises.

There are ethical and safety concerns regarding the use of a probiotic therapeutic. We discussed these issues with the Professor of Health, Law and Policy Jane Kaye. Following her advice we researched more about ethics, including a public survey, discussions about this can be found here.

We had lots of public engagement throughout the year on a local, national and international level!

Gold

Text here