Difference between revisions of "Team:Hong Kong HKUST/IIT"

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<h2 class="text-muted"><em><b>Modelling</b></em></h2><br>
 
<h2 class="text-muted"><em><b>Modelling</b></em></h2><br>
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<p>Apart from the human practices module, we are so grateful to have a collaboration with IIT Madras on modelling and simulation part of the project. IIT Madras performed an mathematical analysis on the tristable system model, and revealed a surprising behaviour of the tristable switch – oscillation occurs under certain conditions. IIT started with developing a Boolean model and first proved the existence of oscillation performed by the tristable system. A more detailed model based on ordinary differential equations was formulated to further characterise the oscillatory behaviour of the system. This further confines the conditions at which oscillation occurs as well as identifying the parameters controlling the magnitude of the oscillation.
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<p>In addition to the collaboration with NUS, we are grateful to work with IIT Madras on modelling and simulation of our project. IIT Madras performed a mathematical analysis on the tristable system model, and revealed a surprising behaviour of the switch – Oscillation occurs under certain conditions.
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The analysis commences with a Boolean model and proved the existence of oscillation performed by the tristable system. A more elaborated model based on ODE was formulated to further characterise the oscillatory behaviour of the system. This further confines the conditions at which oscillation occurs, as well as identifying the parameters controlling the magnitude of the oscillation.
 
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Their findings on the additional behaviour of the tristable switch contribute a lot to our understanding on the system, hence allowing us to tune if not creating new functions to the design.
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Their findings on these additional behaviours of the switch further our understanding on the system; and hence, allowing us to fine tune if no further functions are added to the circuit design.
 
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For detailed analysis, please click <a href = "#" target = "_blank">here</a>.</p>
 
For detailed analysis, please click <a href = "#" target = "_blank">here</a>.</p>
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<p style="color: white; font-size:1.2em;">IIT Madras iGEM team creates a game, Codonut, to teach the players about the codon optimization phenomena which boosts the protein expression during protein synthesis by making use of the ribosomal machinery in cells so that the translational efficiency of the gene of interest can be elevated. Our team tried the game and found that it was really educational and informative. Helping them optimize the game, we gave some comments and solutions towards several problems, like technical issues and tactics for attracting more players. <br><br>
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<p style="color: white; font-size:1.2em;">IIT Madras iGEM team creates a game, Codonut, to teach the players about the codon optimization phenomena which boosts the protein expression during protein synthesis by means of the ribosomal machinery in the cells so that the translational efficiency of the gene of interest can be elevated. Our team tried the game and found that it is really educational and informative. To help them optimize the game, we gave some comments and solutions towards several problems, like technical issues and tactics for attracting more players. <br><br>
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This game is highly recommended so as to learn some biological knowledge. If you are interested, please go to:
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This game is highly recommended for diving into the molecular world in biology. If you are interested, please go to:
 
<ul><a href ="https://play.google.com/store/apps/details?id=com.igemiitm.codonut" target="_blank">https://play.google.com/store/apps/details?id=com.igemiitm.codonut</a>
 
<ul><a href ="https://play.google.com/store/apps/details?id=com.igemiitm.codonut" target="_blank">https://play.google.com/store/apps/details?id=com.igemiitm.codonut</a>
 
<br><a href ="http://www.appstore.com/Codonut" target="_blank">http://www.appstore.com/Codonut</a></ul><br>
 
<br><a href ="http://www.appstore.com/Codonut" target="_blank">http://www.appstore.com/Codonut</a></ul><br>

Revision as of 20:08, 19 October 2016

Home

Collaborations with
iGEM team IIT Madras


Modelling


In addition to the collaboration with NUS, we are grateful to work with IIT Madras on modelling and simulation of our project. IIT Madras performed a mathematical analysis on the tristable system model, and revealed a surprising behaviour of the switch – Oscillation occurs under certain conditions.

The analysis commences with a Boolean model and proved the existence of oscillation performed by the tristable system. A more elaborated model based on ODE was formulated to further characterise the oscillatory behaviour of the system. This further confines the conditions at which oscillation occurs, as well as identifying the parameters controlling the magnitude of the oscillation.

Their findings on these additional behaviours of the switch further our understanding on the system; and hence, allowing us to fine tune if no further functions are added to the circuit design.

For detailed analysis, please click here.

Human Practices


IIT Madras iGEM team creates a game, Codonut, to teach the players about the codon optimization phenomena which boosts the protein expression during protein synthesis by means of the ribosomal machinery in the cells so that the translational efficiency of the gene of interest can be elevated. Our team tried the game and found that it is really educational and informative. To help them optimize the game, we gave some comments and solutions towards several problems, like technical issues and tactics for attracting more players.

This game is highly recommended for diving into the molecular world in biology. If you are interested, please go to:


*To learn more about the project of IIT Madras iGEM team, please go to IIT-Madras.