Difference between revisions of "Team:Bilkent-UNAMBG/Description"
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| + | <h2> Our Project Description, Smelling Cancer </h2> | ||
| + | <p>Cancer is one of the most common and lethal disease in the world and it is always highlighted that early diagnosis is crucial in terms of cancer treatment. It is often invasive and painful to diagnose cancer with the existing methods. At this point, breath test appears as a promising non-invasive and real-time technique which allows the monitoring of metabolic status. </p> | ||
| + | <p> Volatile organic compounds(VOCs) in the exhaled breath provide in vitro detection, classification and discrimination of diseases and microorganisms. Concentration of specific VOCs in the exhaled breath can either increase or decrease depending on the type of diseases and microorganisms.</p> | ||
| + | <p> In this project, our goal is to produce a prototype which can detect and discriminate four most common cancer types: lung, breast, colorectal and prostate. In order to achieve this, we will engineer an artificial plasmid including promoter and reporter genes that are specific to a particular VOC. It is expected that when that particular VOC is given into the environment, bacteria will express reporter gene hence we will get some signal. After achieving getting the signal for a particular VOC, we aim to construct logical gates and circuits by using CRISPRi system on plasmids to create well accoutred bacteria which will be able to differentiate these four cancer types.<p> | ||
| + | <p> Our future goal is to transform our prototype into a kit. So that, diagnosis of cancer will be simpler and non-invasive. <p> | ||
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| + | </div> | ||
<h5>What should this page contain?</h5> | <h5>What should this page contain?</h5> | ||
Revision as of 12:59, 19 July 2016
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Our Project Description, Smelling Cancer
Cancer is one of the most common and lethal disease in the world and it is always highlighted that early diagnosis is crucial in terms of cancer treatment. It is often invasive and painful to diagnose cancer with the existing methods. At this point, breath test appears as a promising non-invasive and real-time technique which allows the monitoring of metabolic status.
Volatile organic compounds(VOCs) in the exhaled breath provide in vitro detection, classification and discrimination of diseases and microorganisms. Concentration of specific VOCs in the exhaled breath can either increase or decrease depending on the type of diseases and microorganisms.
In this project, our goal is to produce a prototype which can detect and discriminate four most common cancer types: lung, breast, colorectal and prostate. In order to achieve this, we will engineer an artificial plasmid including promoter and reporter genes that are specific to a particular VOC. It is expected that when that particular VOC is given into the environment, bacteria will express reporter gene hence we will get some signal. After achieving getting the signal for a particular VOC, we aim to construct logical gates and circuits by using CRISPRi system on plasmids to create well accoutred bacteria which will be able to differentiate these four cancer types.
Our future goal is to transform our prototype into a kit. So that, diagnosis of cancer will be simpler and non-invasive.
What should this page contain?
- A clear and concise description of your project.
- A detailed explanation of why your team chose to work on this particular project.
- References and sources to document your research.
- Use illustrations and other visual resources to explain your project.
Advice on writing your Project Description
We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.
Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
References
iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.
Inspiration
See how other teams have described and presented their projects:
