Team:Goettingen/Notebook


Notebook


  • December 15th, 2015

      May

      5/4/15 - Had first official meeting to review the guidelines of the competition and begin brainstorming ideas for our project.

      5/6/15 - Regrouped to discuss ideas. Entertained diverse ideas from creating a pH sensing bacterium to use as a drug delivery system to fight cancer to using an enterobacterium that would function as a probiotic to try and suppress the Celiac’s disease response to gluten.

      5/9/15 - Decided that focusing on in vivo projects isn’t a good avenue for us to study because of the practical hurdles associated with trying to get an organism to live within the body and then to get that passed by the FDA. Thought about possibly trying to create some sort of helper cell that would aid in vitro screening processes, specifically for cancer research.

      5/11/15 - Over the weekend we intensively studied immunotherapy and its cancer related applications. We thought about trying to create an organism that would maybe aid in the production of T and B-cells.

      5/14/15 - Decided that we didn’t have the proper resources to adequately test anything related to cancer research so we shifted gears. Some of us revisited the Celiac’s disease idea and tried finding a site in the recognition of gluten in an attempt to find a spot to repress the response. The rest then went back to the pH sensing system. We saw this competition as a driving force to construct more parts to expand the registry rather than to create a stand alone project, so creating a pH sensing system could prove useful in other applications.

      5/16/15 - After more investigation we found that other pH sensors had been submitted to the Registry in the past but none were directly linked to transcription factors. So our focused turned to understanding nature’s way of sensing pH.

      5/20/15 - Reconvened to discuss findings. Only a few potential candidates were found but none seemed realistic. We decided to table the idea and keep brainstorming and return to this idea if we were unable to come up with anything else.

      5/23/15 - Entertained the idea of biofuel production. The team went an investigated potential molecules we would produce and the research that has already been done in this competition and out.

      5/28/15 - Started thinking more big picture about the goals of the synthetic biology and what kind of problems it can realistically solve at this point in time. We thought about how it is that such small organisms can have larger effects on society. This idea of scaling up biology bot us thinking about bioreactors.

  • 01.01.2020
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  • 10.01.2021
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Document the dates you worked on your project.

What should this page have?
  • Chronological notes of what your team is doing.
  • Brief descriptions of daily important events.
  • Pictures of your progress.
  • Mention who participated in what task.
Inspiration

You can see what others teams have done to organize their notes:


Contact


iGEM Team Göttingen 2016
Institut für Mikrobiologie
und Genetik
AG Prof. Dr. Rolf Daniel
Grisebachstr. 8
37077 Göttingen

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