Team:NJU-China/Attributions

Attributions

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TEAM

The team consists of students from different grades of bachelor’s degree, armed with varied but complementary expertise. It was founded in winter of year 2015, 3 months after which the general topic of this project (a new treatment for cancer) was determined through the process of brainstorming, article reading and debating. Then questionnaires had been sent out to get public expectation for cancer treatment. Under the guidance of Prof. Xi Chen and Prof. Chenyu Zhang, and based on survey results and deeper understanding of related research articles, the ultimate idea was established on March of 2016.

• Chenhui Deng

  Chenhui Deng is one of the two who in charge of all the qPCR experiments in both in vivo and in vitro validation of iRGD-siRNA-exosome function. It was him who pointed out that we should referred to the view from public (both general one and patients) to value if our idea did have its practical significance. He will represent the whole team to present our project at the final Jamboree.

  
  
• Jingyi Chen

  Jingyi Chen learned cell proliferation assay and endotoxin detecting assay from our advisors, two graduate students in Prof. Xi Chen’s lab, to ascertain iRGD-siRNA-exosome can suppress cancer cells’ proliferation and to prove our drug system is nontoxic for normal cells, respectively. In human practice, she accompany with Jiaxin Cai to deeply interview the doctor from a local hospital. Also, she will present our project at the final Jamboree together with Chenhui Deng.

  
  
• Xiaoyang Gu

  Xiaoyang Gu is the master of western blot, conducting all the experiments that proved significant decrease of our target gene (KRAS) in the protein level after treated with iRGD-siRNA-exosomes. During this process, she learned transmission electron microscope assay (TEM) from a graduate student in Prof. Xi Chen’s lab, to ensure we get exosomes after collection assay according to the morphology of the harvest, and also determine exosomes’ density.

  
  
• Yingzi Chai

  Yingzi Chai is responsible for our BioBricks construction and has persistently performed cloning for genes of shRNA and iRGD-Lamp2b fusion protein. She did qPCR experiments for siRNA’s silencing validation in vivo and in vitro together with Chenhui Deng. Besides, she is the third person who will present our work at the Giant Jamboree.

  
  
• Yue Peng

  Yue Peng learned animal surgery from graduate students and is responsible for our non-small cell lung cancer mouse model. In addition, she was the babysitter of both our chassis cells and cancer cells, setting the basis of all the in vivo and in vitro experiments. And after we got our questionnaires back from both general public and cancer patients, she did the analysis and made conclusion from the survey.

  
  
• Zining Yang

  Zining Yang learned animal surgery from graduate students, conducting both intravenous exosome injection and lung tumor harvest and measurement. Her work proved our drug system could truly have effects on tumor cells in vivo. Moreover, she designed our questionnaires for general public, to get their cognition of cancer and its related treatment.

  
  
• Jiaxin Cai

  Jiaxin Cai is a junior student from the School of Journalism and Communication. She’s interested in our idea of combining scientific research with realistic social problems, thus provided her great help in our public outreach. She designed questionnaires for cancer patients and conducted deep interviews with patients and doctors, summarized their points of view about new treatment of cancer cases and especially about our project.

  
  
• Yandong Liu

  Yandong Liu is responsible for our website design and construction. He cooperated with other team members to finish this wiki and made it to be fascinating. His continuous debugging and considerate web layout made it welcoming and comfortable for our wiki readers.

  
  
• Waner Jiang and Ling Jin

  Waner Jiang and Ling Jin are senior students from the School of Life Sciences and have joined an iGEM team last year. They founded this team, recruited all the members and allocated assignments to us everyone based on our specialties and interests. There is no doubt that their outstanding leadership ensured everything that needed to be done would finally get settled.