- Developed an initial proof of concept for a Wilson’s Disease therapeutic as an alternative to current treatments, which have problems associated with their cost, side-effects and high dosage frequency.
- We added 13 new BioBrick parts to the iGEM registry. Check our parts page for more information.
- We investigated several different promoters and two different copper chelators with the aim of finding the most effective system.
- We successfully designed composite parts with a copper chelator under control of a copper-sensitive promoter. Check out our results page for more information.
- Discussions with the wider community played a major role in our project. We spoke to doctors and patients about Wilson’s Disease and used their feedback to guide our project. Check out our Human Practices Hub for more information.
Bronze
We’re ready for Boston in every way after the summer of our lives. Counting down the days to the Giant Jamboree!
All submitted with love and hard work. Our judging form is here.
We have many to thank and you can find out about them here.
BBa_K1980000 and BBa_K1980001 are both are new to the Registry. Find out more about them on our Parts page.
Silver
pCopA MymT sfGFP with constitutively expressed CueR works as expected. Our team performed flow cytometry, plate reader experiments and microscopy studies on this part, all of which can be found here.
We carried out a joint survey with Vilnius-Lithuania iGEM team and created models for their project. We sent Cardiff iGEM 3 of our parts which they very kindly studied using a fluorescence lifetime microscope. You can find out more about our collaborations here.
There are ethical and safety concerns regarding the use of a probiotic therapeutic. We discussed these issues with the Professor of Health, Law and Policy Jane Kaye. Following her advice we researched more about ethics, including a public survey, discussions about this can be found here.
We had lots of public engagement throughout the year on a local, national and international level!
Gold
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