Team:CGU Taiwan/Model
Leijuvant
Modeling Motivation
In our 2016 iGEM project, immune and protein information searching is inevitiably required. Therefore, McHug is a software platform that is created to arrange your data and search the protein infomations from several databases. We will output your data with a user-friendly interface and you can easily browse the results by submitting in a requested form. The concept of McHug software is originated from 2016 CGU iGEM group. We aim to test the potential of Leishmania to be a new vaccine adjuvant by carrying antigens directly into immune cells. The antigen peptides will be presented on MHCI or II molecules to activate T cells. Therefore, McHug is created to predict the peptides on MHC molecules and help to optimize the peptide presentation and T cell activation. Also, cloning efficiency is considered to be a important step of the experiment. We then expect that this platform and help us shorten the antigen sequence so that it can be more effective to subclone the shuttle vector.
Demo
This demo clip was filmed to showcase how to use McHug software and explan the function of result page. The protein ID we used in this clip was OVA protein so that you can see the result of our targeting antigen. The ultimate goal of McHug platform is to integrate several protein databases and provide the users with easy-understanding illustrations.
So far, we are able to show you protein 3D structure on the top of the interface. You can easily zoom in and zoom out to peek every part of your protein. And even select a partial peptide sequence. The peptide sequence in the protein will light up and reveal its position in the 3D structure. Moreover, MHC binding affinity and protein annotations are shown below. Amino acid positions are arranged correspondingly so that you can check all the information side by side. McHug 2016 also features the visualized interface which can transform loads of numerical data into legible charts and all basic protein information are integrated into a canvas penal at the buttom of the page.
Results
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Notebook
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Week 1 (5/1~5/8)
Tim Berners-Lee invented the World Wide Web in 1989, about 20 years after the first connection was established over what is today known as the Internet. At the time, Tim was a software engineer at CERN, the large particle physics laboratory near Geneva. Many scientists participated in experiments at CERN for extended periods of time, then returned to their laboratories around the world. These scientists were eager to exchange data and results, but had difficulties doing so. Tim understood the unrealized potential of millions of computers connected together through the Internet.
Week 2 (5/9~5/15)
Week 3 (5/16~5/22)
Week 4 (5/23~5/31)
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Week 1 (6/1~6/5)
Tim Berners-Lee invented the World Wide Web in 1989, about 20 years after the first connection was established over what is today known as the Internet. At the time, Tim was a software engineer at CERN, the large particle physics laboratory near Geneva. Many scientists participated in experiments at CERN for extended periods of time, then returned to their laboratories around the world. These scientists were eager to exchange data and results, but had difficulties doing so. Tim understood the unrealized potential of millions of computers connected together through the Internet.
Week 2 (6/6~6/12)
Week 3 (6/13~6/19)
Week 4 (6/20~6/26)
Week 5 (6/27~7/3)
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Week 1 (7/4~7/10)
Tim Berners-Lee invented the World Wide Web in 1989, about 20 years after the first connection was established over what is today known as the Internet. At the time, Tim was a software engineer at CERN, the large particle physics laboratory near Geneva. Many scientists participated in experiments at CERN for extended periods of time, then returned to their laboratories around the world. These scientists were eager to exchange data and results, but had difficulties doing so. Tim understood the unrealized potential of millions of computers connected together through the Internet.
Week 2 (7/11~7/17)
Week 3 (7/18~7/24)
Week 4 (7/25~7/31)
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Week 1 (8/1~8/7)
Tim Berners-Lee invented the World Wide Web in 1989, about 20 years after the first connection was established over what is today known as the Internet. At the time, Tim was a software engineer at CERN, the large particle physics laboratory near Geneva. Many scientists participated in experiments at CERN for extended periods of time, then returned to their laboratories around the world. These scientists were eager to exchange data and results, but had difficulties doing so. Tim understood the unrealized potential of millions of computers connected together through the Internet.
Week 2 (8/8~8/14)
Week 3 (8/15~8/21)
Week 4 (8/22~8/28)
Week 5 (8/19~9/4)
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Week 1 (9/5~9/11)
Tim Berners-Lee invented the World Wide Web in 1989, about 20 years after the first connection was established over what is today known as the Internet. At the time, Tim was a software engineer at CERN, the large particle physics laboratory near Geneva. Many scientists participated in experiments at CERN for extended periods of time, then returned to their laboratories around the world. These scientists were eager to exchange data and results, but had difficulties doing so. Tim understood the unrealized potential of millions of computers connected together through the Internet.
Week 2 (9/12~9/18)
Week 3 (9/19~9/25)
Week 4 (9/26~10/2)
Week 5 (8/19~9/4)
