<div id=page style = "width: 50%; margin-left:25%; margin-right: 25%;" > <p style = " color:#e69900; font-size: 16px; text-align: centre; font-family: 'Roboto Slab', serif; " > <h5> <b> <br> <br> There is strong evidence supporting such a hypothesis: </h5> </b>
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<div id=page style = "width: 50%; margin-left:25%; margin-right: 25%;" > <p style = " color:#e69900; font-size:18px; text-align: centre; font-family: "Roboto Slab", serif; " > <b> <br> <br> There is strong evidence supporting such a hypothesis: </b>
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<p style = "color:#e69900; font-size: 16px; text-align: centre; font-family: "Roboto Slab", serif; " > <b>EtnR1 and EtnR2 are the only genes of unknown function in the well-characterised ethylene metabolism operon. </b> </p> <p>
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<p style = "color:#e69900; font-size: 16px; text-align: centre; font-family: 'Roboto Slab', serif; " > <b>EtnR1 and EtnR2 are the only genes of unknown function in the well-characterised ethylene metabolism operon. </b> </p> <p>
The regulation of the genes responsible for ethylene degradation is also unknown. This may suggest that EtnR1 and EtnR2 are involved in regulating this process. <br>
The regulation of the genes responsible for ethylene degradation is also unknown. This may suggest that EtnR1 and EtnR2 are involved in regulating this process. <br>
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<p style = " color:#e69900; font-size: 16px; font-family: "Roboto Slab", serif; text-align: centre; " > <b> EtnR1 and EtnR2 are highly conserved across ethylene-oxidising Mycobacterium. </b> </p> <p>
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<p style = " color:#e69900; font-size: 16px; font-family: 'Roboto Slab', serif; text-align: centre; " > <b> EtnR1 and EtnR2 are highly conserved across ethylene-oxidising Mycobacterium. </b> </p> <p>
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<p style = " color:#e69900; font-size: 16px; font-family: "Roboto Slab", serif; text-align: centre;" > <b> The closest homologue of EtnR1 is CdaR which forms part of a two component regulatory system common in bacterial gene regulation.</b> </p> <p>
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<p style = " color:#e69900; font-size: 16px; font-family: 'Roboto Slab', serif; text-align: centre;" > <b> The closest homologue of EtnR1 is CdaR which forms part of a two component regulatory system common in bacterial gene regulation.</b> </p> <p>
CdaR has been identified as a potential regulator of bacterial diadenylate cyclase, which synthesises the second messenger cyclic diadenylate monophosphate (Mehne et al. 2013, Rismondo et al. 2016). While CdaR has not been well studied, it has been suggested to be a negative regulator of diadenylate cyclase.
CdaR has been identified as a potential regulator of bacterial diadenylate cyclase, which synthesises the second messenger cyclic diadenylate monophosphate (Mehne et al. 2013, Rismondo et al. 2016). While CdaR has not been well studied, it has been suggested to be a negative regulator of diadenylate cyclase.
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<p style = " color:#e69900; font-size: 16px; font-family: "Roboto Slab", serif; text-align: centre;" > <b> EtnR1 has DNA-binding and kinase domains and EtnR2 has a MEDS domain. </b> </p> <p>
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<p style = " color:#e69900; font-size: 16px; font-family: 'Roboto Slab', serif; text-align: centre;" > <b> EtnR1 has DNA-binding and kinase domains and EtnR2 has a MEDS domain. </b> </p> <p>