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A biosilica-based detection device for (re)emerging arboviral infectious diseases

The global distribution of arboviruses.

The massive use of insecticides causes resistance in mosquitoes.

After many brainstorming sessions and after an exhaustive literature search...

MOS(KIT)O emerged!!

Abstract

Vector-borne (re) emerging diseases are responsible for severe epidemics worldwide. In most cases, vaccines or treatments are not available, and insecticides are the primary source for vector control. Consequently, over spraying of insecticides impacts the environment and leads to the selection of insecticide resistant mosquitoes. Therefore, we developed a novel diagnostic device, Mos(kit)o that includes a fixed or mobile mosquito trap and a biosilica cellulose composite patch from genetically modified E. coli. The design of the patch creates a multilayered matrix coated with antibodies capable of detecting a wide panel of vector-borne pathogens and insecticide resistant proteins from captured mosquitoes. Additionally, the patch will have 2D barcoded readouts, generating an environmental surveillance database. A precise map of vector hot spots will provide a better assessment and response to vector-borne diseases, assisting local health authorities with anticipating and preparing for an epidemic. Our tool will be user-friendly, safe, and applicable.