Difference between revisions of "Team:TAS Taipei/Proof"

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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2016.igem.org/Judging/Medals">gold medal criterion for proof of concept</a>. </p>
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<p> Delete this box in order to be evaluated for this medal. See more information at <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions"> Instructions for Pages for awards</a>.</p>
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<nav style='font-family:Lato;font-size:22px;background-color:#1C77C3;-webkit-transform: translateZ(0);z-index: 100;position: fixed;box-shadow: 0px 0px 10px black;'>
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<ul style='margin-left:0px'>
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<li class="dropdown">
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<a href="https://2016.igem.org/Team:TAS_Taipei/Description"><h4 class="dropdown-toggle disabled" data-toggle="dropdown"><b>PROJECT</b></h4></a>
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<div class="dropdown-menu">
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<div class='subcategories_container'>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Description">Background</a></h5>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Achievements">Achievements</a></h5>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Collaborations">Collaborations</a></h5>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Parts">Parts</a></h5>
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</div>
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</div>
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<div style='height:140px;'>
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<img src="https://static.igem.org/mediawiki/2016/1/11/T--TAS_Taipei--TAS_Icon_Project.png">
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<h4><b>Cataracts</b> - the leading cause of blindness. Find out how we can non-invasively <b>treat</b> and <b>prevent</b> cataract formation.</b></h4>
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</div>
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</div>
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</li>
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<li class="dropdown">
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<a href="https://2016.igem.org/Team:TAS_Taipei/Experimental_Summary"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>EXPERIMENTAL</b></h4></a>
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<div class="dropdown-menu">
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<div class='subcategories_container'>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Experimental_Summary#lensmodel">Lens Cataract Model</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Experimental_Summary#construct">Prevention and Treatment Constructs </a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Experimental_Summary#prototype">Delivery Prototype</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Notebook">Notebook</a></h5>
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</div>
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</div>
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<div style='height:140px;'>
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<img src="https://static.igem.org/mediawiki/2016/b/b0/T--TAS_Taipei--TAS_Icon_Experiments.png">
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                        <h4>We build <b>constructs</b> to make our great ideas become reality. Follow along our discovery of exciting science!</h4>
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</div>
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</div>
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</li>
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<li class="dropdown">
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<a href="https://2016.igem.org/Team:TAS_Taipei/Model"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>MODEL</b></h4></a>
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<div class="dropdown-menu">
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<div class='subcategories_container'>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Model#GSRFunc">GSR Function</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Model#prototype">Prototype Delivery</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Model#treatment">CH25H Treatment</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Model#software">Calculator</a></h5>
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</div>
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</div>
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<div style='height:140px;'>
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<img src="https://static.igem.org/mediawiki/2016/c/ca/T--TAS_Taipei--TAS_Icon_Model.png">
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<h4><b>Computational Biology</b> provides us models that we cannot easily test experimentally. Click to find out the results of our modeling, and the math behind it!</h4>
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</div>
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</div>
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</li>
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<li class="dropdown">
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<a href="https://2016.igem.org/Team:TAS_Taipei/Human_Practices"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>HUMAN PRACTICE</b></h4></a>
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<div class="dropdown-menu">
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<div class='subcategories_container'>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Human_Practices#research">Research</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Human_Practices#outreach">Outreach</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Human_Practices#impact">Impact</a></h5>
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</div>
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</div>
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<div style='height:140px;'>
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<img src="https://static.igem.org/mediawiki/2016/b/b9/T--TAS_Taipei--TAS_Icon_HP.png">
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<h4>We don't just grow cool bacteria. We make a <b>difference</b>. Find out how we tackled <b>social aspects</b> of this project.</h4>
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</div>
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</div>
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</li>
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<li class="dropdown">
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<a href="https://2016.igem.org/Team:TAS_Taipei/Safety"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>BIOSAFETY</b></h4></a>
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<div class="dropdown-menu">
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<div style='height:100px;'>
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<div class='subcategories_container'>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Safety#overview">Overview</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Safety#biosafety">Biosafety</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Safety#riskreduction">Risk Reduction Methods</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Safety#furtherquestion">Further Questions</a></h5>
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</div>
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</div>
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<img src="https://static.igem.org/mediawiki/2016/7/7e/T--TAS_Taipei--TAS_Icon_Safety.png">
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<h4><b>Safety first.</b> Especially in a lab. Here's how we maintained and investigated the integrity and security of our work environment.</h4>
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</div>
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</div>
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</li>
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<li class="dropdown">
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<a href="https://2016.igem.org/Team:TAS_Taipei/Team"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>TEAM</b></h4></a>
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<div class="dropdown-menu">
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<div class='subcategories_container'>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Team#members">Members</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Team#about">About</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Attributions">Attributions</a></h5>
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</div>
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<div>
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<h5><a href="https://2016.igem.org/Team:TAS_Taipei/Wiki_Standard_Pages">Wiki Standard Pages</a></h5>
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</div>
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</div>
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<div style='height:140px;'>
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<img src="https://static.igem.org/mediawiki/2016/c/c6/T--TAS_Taipei--TAS_Icon_Team.png">
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<h4>Every iGEM project is the accumulation of an entire year's hard work by a group of cheerful students. <b>Meet the team!</b></h4>
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</div>
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</div>
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</li>
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</ul>
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</nav>
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<div class="col-sm-2">
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<a href="https://2016.igem.org/Team:TAS_Taipei" style='text-decoration: none'><img src="https://static.igem.org/mediawiki/2016/c/c6/T--TAS_Taipei--TAS_iGEM_Logo.png
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" alt="" style="width: 100px;"></a>
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<div class="col-sm-8" style='text-align:center;'>
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<a href="https://2016.igem.org/Team:TAS_Taipei" style='text-decoration: none;'>
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<h2 style="font-family:'Lato';letter-spacing:10px;color: white; font-size: 60px;  margin-top: 0;  margin-bottom: 0;"><b>
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C&#9678;UNTERACTS</b></h2>
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</a>
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<div class="col-sm-2">
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<a href="https://igem.org/HS"><img src="https://static.igem.org/mediawiki/2016/6/6e/T--TAS_Taipei--TAS_Icon_Logo2.png" alt="" style="width: 100px;"></a>
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<ul class="nav nav-list" data-spy="affix" data-offset-top="160" style='-webkit-transform: translateZ(0);width:160px;margin-left:0' >
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<li><a href="#lensmodel">Lens Cataract Model</a></li>
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                        <ul>
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                            <li> <a href="#LensPrevention">Prevention</a></li>
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                            <li> <a href="#LensTreatment">Treatment</a></li>
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                        </ul>
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<li><a href="#construct">Construct</a></li>
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                        <ul>
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                            <li> <a href="#ConstructPrevention">Prevention</a></li>
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                            <li> <a href="#ConstructTreatment">Treatment</a></li>
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                        </ul>
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                        <li><a href="#prototype">Delivery Prototype</a></li>
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                        <ul>
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                            <li> <a href="#step1">Purification</a></li>
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                            <li> <a href="#step2">Nanoparticle</a></li>
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                            <li> <a href="#step2i">Encapsulation</a></li>
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                            <li> <a href="#step2ii">Release</a></li>
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                            <li> <a href="#step3">Application</a></li>
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                        </ul>
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</ul>
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</div>
  
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</div>
  
  
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<div class="col-sm-10" style="padding-right:5%">
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<h1>Proof of Concept</h1>
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                  <div class = "row">
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              <div class="col-sm-12">
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        <h2 id = 'construct'>Research</h2>
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                                <div class="col-sm-12">
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                                <h3 id="ConstructPrevention"></h3>
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                                    <br>
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                                <h3>Professional Help</h3>
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                                <p>
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                                    In order to improve how we develop our prototype we needed to get in contact with experts in the fields of eye surgery and cataracts research. Our first step was to contact eye doctors to discuss any problems associated with current cataracts treatment. Finally, while developing our project we realized that cataracts is a major issue in pets and other animals as well as people. As a result, we contacted local veterinarians to discuss what pet owners do when their pets contract cataracts. As our project developed, we needed more specific information regarding our genes of interest, cataracts development, and our delivery mechanism. We contacted scientists doing research similar to our own to get their opinion on our projects progress.
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                                </p>
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                                </div>
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                            </div>
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                          <br><br>
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                            <div class="row">
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                                <div class="col-sm-12">
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                                    <h3 id="ConstructPrevention"></h3>
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                                        <br>
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                                    <h4>Contact with Eye Doctors</h4>
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                                    <p>
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                                        Eye doctors are on the front lines, delivering cataracts surgery, some privately and others for charity in organizations such as the Himalayan Cataracts Projects. We contacted local Taiwanese Eye Doctors to ask them about cataracts surgery. Here is a list of the doctors we contacted along with the information they provided:
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                                    </p>
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                                </div>
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                                    <h3 id="ConstructPrevention"></h3>
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                                        <br>
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                                    <p>
 +
                                        Dr. Wei-Chi Wu is a retina specialist and an associate professor at Chang Gung memorial hospital in Taiwan. According to Dr. Wu current cataracts surgery methods are efficient and effective, but are not without their issues. Besides the issue of price, there can also be several different post-surgery complications such as infection, hemorrhaging, or secondary glaucoma. In regards to our project, he said one of the biggest issues we would face is non-invasive delivery. Currently, injections and incisions are the only methods for delivery because all current potential methods of noninvasive delivery either lack efficiency or induce with side effects.
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                                    </p>
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                                <figure class = "col-sm-6">
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        <img src="https://static.igem.org/mediawiki/2016/6/67/T--TAS_Taipei--GSR_Construct_Experimental.jpg">
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                                    <figcaption class='darkblue'><b>Figure X. </b>Full Construct.</figcaption>
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                                </figure>
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<h3>Citations</h3>
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        <br> <br>  <br>  <br>  <br>  <br>  <br>  <br>           
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iGEM teams are great at making things work! We value teams not only doing an incredible job with theoretical models and experiments, but also in taking the first steps to make their project real.
 
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<h4> What should we do for our proof of concept? </h4>
 
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<p>
 
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You can assemble a device from BioBricks and show it works. You could build some equipment if you're competing for the hardware award. You can create a working model of your software for the software award. Please note that this not an exhaustive list of activities you can do to fulfill the gold medal criterion. As always, your aim is to impress the judges!
 
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            if ($("#bluebutton").hasClass("isOn") ) {return;};
 +
            if($('#redbutton').hasClass("isOn") ) {return;}
 +
            $('.backgroundpic').css({
 +
                "-webkit-filter": "blur("+this.blurRadius+"px)",
 +
                "filter": "blur("+this.blurRadius+"px)"
  
 +
            });
 +
            nowRadius = this.blurRadius;
 +
        var LOCSnum = Math.round(nowRadius*6/9);
 +
        var NineLOCSnum = Math.round(nowRadius*6/9*10);
 +
        /**if (NineLOCSnum > 20) switchMessage("YELLOW","<b> Oh no! </b> Cataracts are forming! Click on the Eyedrop Tab and get <b>TREATMENT</b> eyedrops!", currentColor()=="GREEN");
 +
        if (NineLOCSnum == 55) $("#slideoutco").fadeOut(1000);
 +
        if (NineLOCSnum > 60) switchMessage("RED","Your cataracts are very severe. You need to get TREATMENT fast by clicking the Eyedrop Tab", currentColor()=="YELLOW");*/
 +
        if (LOCSnum > 6) {LOCSnum = "6+"; $('#LOCS').text(LOCSnum+"");}
 +
        else $('#LOCS').text(LOCSnum+"");
 +
       
 +
        if (LOCSnum ==0) document.getElementById('bluebutton').click();
 +
        }
 +
    });
  
 +
});
 +
 +
startBlur= function(speed) {
 +
    $({blurRadius: nowRadius}).animate({blurRadius: 10}, {
 +
        duration: speed,
 +
        easing: 'swing', // or "linear"
 +
                        // use jQuery UI or Easing plugin for more options
 +
        step: function() {
 +
            console.log(this.blurRadius);
 +
            if ($("#bluebutton").hasClass("isOn") ) {return;};
 +
            if($('#redbutton').hasClass("isOn") ) {return;}
 +
 +
            $('.backgroundpic').css({
 +
                "-webkit-filter": "blur("+this.blurRadius+"px)",
 +
                "filter": "blur("+this.blurRadius+"px)"
 +
 +
            });
 +
 +
        nowRadius = this.blurRadius;
 +
        var LOCSnum = Math.round(nowRadius*6/9);
 +
        var NineLOCSnum = Math.round(nowRadius*6/9*10);
 +
        /**if (NineLOCSnum == 15) $("#slideoutco").fadeOut(400);
 +
        if (NineLOCSnum > 20) switchMessage("RED","<b>Cataracts</b> are creeping back again! Click the PREVENTION eyedrop to add GSR into your eyes!", currentColor()=="BLUE");*/
 +
        if (LOCSnum > 6) {LOCSnum = "6+"; $('#LOCS').text(LOCSnum+"");}
 +
        else $('#LOCS').text(LOCSnum+" ");
 +
       
 +
       
 +
        }
 +
    });
 +
};
 +
 +
stopBlur= function(speed) {
 +
 +
    $({blurRadius: nowRadius}).animate({blurRadius: 0}, {
 +
        duration: speed,
 +
        easing: 'swing', // or "linear"
 +
                        // use jQuery UI or Easing plugin for more options
 +
        step: function() {
 +
            console.log(this.blurRadius);
 +
        if ($("#redbutton").hasClass("isOn") ) {} else{return;};
 +
            $('.backgroundpic').css({
 +
                "-webkit-filter": "blur("+this.blurRadius+"px)",
 +
                "filter": "blur("+this.blurRadius+"px)"
 +
 +
            });
 +
        nowRadius = this.blurRadius;
 +
        var LOCSnum = Math.round(nowRadius*6/9);
 +
        var NineLOCSnum = Math.round(nowRadius*6/9*10);
 +
         
 +
        /**if (NineLOCSnum < 68){ if (NineLOCSnum > 10) if(currentColor()=="RED" ||  currentColor() == "BLUE") $("#slideoutco").fadeOut(0); switchMessage("YELLOW","<b> Treating</b> your cataract with <b>25HC Eyedrops </b>", currentColor()=="RED");
 +
                              }
 +
        if (NineLOCSnum == 9) $("#slideoutco").fadeOut(0);
 +
       
 +
           
 +
        if (NineLOCSnum < 5) {
 +
            if ($("#bluebutton").hasClass("isOn")){
 +
                   
 +
                switchMessage("GREEN","<b>Your eyes are <i>pernamently</i> crystal clear!</b> Treatment is not needed, so don't forget to turn it off!. Click the question mark to learn more.", currentColor()=="BLUE")
 +
            }
 +
            else switchMessage("BLUE","Your eyes are crystal clear! To avoid waste, please turn off the <b>TREATMENT</b> eyedrop.", currentColor()=="YELLOW");
 +
        }*/
 +
        if (LOCSnum > 6) LOCSnum = "6+";
 +
        else LOCSnum = LOCSnum +" ";
 +
        $('#LOCS').text(LOCSnum+"");   
 +
       
 +
        }
 +
    });
 +
   
 +
   
 +
};
 +
 +
function chooseBlur() {
 +
  if ($("#redbutton").hasClass("isOn") )
 +
      {
 +
      stopBlur(4500);
 +
 
 +
            }
 +
 
 +
    else {
 +
            if($("#bluebutton").hasClass("isOn") ) {}
 +
            else {startBlur(12000);}
 +
          }
 +
    /**if (!$("#redbutton").hasClass("isOn"))
 +
        if ($("#bluebutton").hasClass("isOn"))
 +
            {
 +
                $("#slideoutco").fadeOut(0);
 +
                switchMessage("BLUE","Great! Furthur cataract formation is prevented with GSR Eyedrops. Now use <b>TREATMENT</b> eyedrops one last time.", currentColor()=="RED")
 +
            }*/
 +
};
 +
 +
 +
</script>
 +
 +
<script>
 +
 +
function switchToggleB() {
 +
    if ( $("#bluebutton").hasClass("isOn") ) {
 +
        $("#bluebutton").removeClass("isOn"); }
 +
  else { $("#bluebutton").addClass("isOn"); }
 +
};
 +
function switchToggleR() {
 +
    if ( $("#redbutton").hasClass("isOn") ) {
 +
        $("#redbutton").removeClass("isOn"); }
 +
  else { $("#redbutton").addClass("isOn"); }
 +
};
 +
   
 +
function currentColor() {
 +
    if ($("#slidecontenttext").hasClass("alert-danger"))
 +
        return "RED";
 +
    if ($("#slidecontenttext").hasClass("alert-warning"))
 +
        return "YELLOW";
 +
    if ($("#slidecontenttext").hasClass("alert-info"))
 +
        return "BLUE";
 +
    if ($("#slidecontenttext").hasClass("alert-success"))
 +
        return "GREEN";
 +
    else return "NONE"
 +
};
 +
function switchMessage(color, textInside, refresh) {
 +
    var entirebox = document.getElementById("slideoutco");
 +
 +
    if (refresh)
 +
    {$(entirebox).fadeOut(100);
 +
    if ($("#slidecontenttext").hasClass("alert-danger"))
 +
        $("#slidecontenttext").removeClass("alert-danger");
 +
    if ($("#slidecontenttext").hasClass("alert-warning"))
 +
        $("#slidecontenttext").removeClass("alert-warning");
 +
    if ($("#slidecontenttext").hasClass("alert-info"))
 +
        $("#slidecontenttext").removeClass("alert-info");
 +
    if ($("#slidecontenttext").hasClass("alert-success"))
 +
        $("#slidecontenttext").removeClass("alert-success");
 +
    if (color == "RED")
 +
        $("#slidecontenttext").addClass("alert-danger");
 +
    if (color == "YELLOW")
 +
        $("#slidecontenttext").addClass("alert-warning");
 +
    if (color == "BLUE")
 +
        $("#slidecontenttext").addClass("alert-info");
 +
    if (color == "GREEN")
 +
        $("#slidecontenttext").addClass("alert-success");
 +
   
 +
   
 +
    $("#slidecontenttext").html(textInside);
 +
    $(entirebox).fadeIn(500);
 +
    }
 +
   
 +
};
 +
 +
 +
</script>
 +
 +
 +
 +
 +
 +
 +
<canvas id="canvas-container" style = "z-index:-1" hidden></canvas>
 +
<script type="text/javascript" src='https://2015.igem.org/Template:TAS_Taipei/js/field?action=raw&ctype=text/javascript' hidden></script/>
 +
 +
 +
 +
<script type="text/javascript">
 +
/* Toggle between adding and removing the "active" and "show" classes when the user clicks on one of the "Section" buttons. The "active" class is used to add a background color to the current button when its belonging panel is open. The "show" class is used to open the specific accordion panel */
 +
var acc = document.getElementsByClassName("accordion");
 +
var i;
 +
 +
for (i = 0; i < acc.length; i++) {
 +
    acc[i].onclick = function(){
 +
        this.classList.toggle("active");
 +
        this.nextElementSibling.classList.toggle("show");
 +
    }
 +
}
 +
</script>
 +
 +
<script type="text/javascript">
 +
$("#category_navbar a").on('click', function(event) {
 +
    // Make sure this.hash has a value before overriding default behavior
 +
    if (this.hash !== "") {
 +
      // Prevent default anchor click behavior
 +
      event.preventDefault();
 +
 +
      // Store hash0
 +
      var hash = this.hash;
 +
 +
      // Using jQuery's animate() method to add smooth page scroll
 +
      // The optional number (800) specifies the number of milliseconds it takes to scroll to the specified area
 +
      $('html, body').animate({
 +
        scrollTop: $(hash).offset().top
 +
      }, 800, function(){
 +
 
 +
        // Add hash (#) to URL when done scrolling (default click behavior)
 +
        window.location.hash = hash;
 +
      });
 +
    }  // End if
 +
  });
 +
 +
 +
</script>
 +
 +
<div id="slideout">
 +
    <div id="slidecontent">
 +
        <h3>Prevention</h3>
 +
        <h5>GSR Eyedrop</h5>
 +
        <label class="switch">
 +
            <input id="bluebutton" onClick="switchToggleB(); chooseBlur()" type="checkbox">
 +
            <div class="slider round bluecolorbutton"></div>
 +
        </label>
 +
<br>
 +
 +
        <h3>Treatment</h3>
 +
        <h5>25HC Eyedrop</h5>
 +
        <label class="switch">
 +
            <input id="redbutton" onClick="switchToggleR(); chooseBlur()" type="checkbox">
 +
            <div class="slider round redcolorbutton"></div>
 +
        </label>
 +
        <h4><b> LOCS: <span id="LOCS">0 &#160;</span></b> &#160; &#160; <a href="https://2016.igem.org/Team:TAS_Taipei/Wiki_Standard_Pages#Animation"><button  type="button" class="btn btn-danger btn-md">?</button> </a>
 +
 +
    </div>
 +
    <div id="clickme">
 +
    <h2 class="vertical-text" style="Lato" !important>
 +
            <br> Eyedrops
 +
    </h2>
 +
        <br><br><br>
 +
       
 +
    </div>
 
</div>
 
</div>
 +
 +
<div id="slideoutco">
 +
    <div id="slidecontentco">
 +
        <div id="slidecontenttext" class="alert alert-danger">
 +
            <p style="font-size:14px !important"> <a href="#" class="close" data-dismiss="alert" style="font:18px">&times;</a>
 +
                <strong>The tutorial is disabled.</strong> &#160; &#160; &#160; &#160; &#160;<a href="https://2016.igem.org/Team:TAS_Taipei/Wiki_Standard_Pages#Animation"><button  type="button" class="btn btn-danger btn-sm">?</button> </a><span style="font-size:14px"><br>Turn off prevention eyedrops to activate the animation. For a full tutorial, click the question mark. </span></p>
 +
           
 +
        </div>
 +
    </div>
 +
</div>
 +
 +
<javascript>
 +
   
 +
</javascript>
 +
 +
<style type='text/css'>
 +
 +
#slideout {
 +
    background: #FFD700;
 +
    position: fixed;
 +
    height: 300px;
 +
    width: 200px;
 +
    top: 30%;
 +
    right:-150px;
 +
    padding-left: 60px;
 +
    z-index:30;
 +
    border-radius: 25px;
 +
 +
 +
}
 +
   
 +
#slideoutco {
 +
    position: fixed;
 +
    height: 200px;
 +
    width: 300px;
 +
    top: 78%;
 +
    right:1%;
 +
    padding-left: 10px;
 +
    padding-right: 10px;
 +
    border-radius: 10px;
 +
    z-index:30;
 +
}
 +
   
 +
#clickme {
 +
    position: absolute;
 +
    top: 0; left: 0;
 +
    height: 300px;
 +
    width: 50px;
 +
    background: #FFBA49;
 +
    z-index:30;
 +
    border-radius: 25px 5px 5px 25px;
 +
}
 +
 +
#slidecontent {
 +
    float:left;
 +
}
 +
   
 +
#slidecontentco {
 +
    float:left;
 +
}
 +
 +
.vertical-text {
 +
transform: rotate(90deg);
 +
transform-origin: left bottom 0;
 +
  float: left;
 +
}
 +
/* The switch - the box around the slider */
 +
.switch {
 +
  position: relative;
 +
  display: inline-block;
 +
  width: 60px;
 +
  height: 34px;
 +
}
 +
 +
/* Hide default HTML checkbox */
 +
.switch input {display:none;}
 +
 +
/* The slider */
 +
.slider {
 +
  position: absolute;
 +
  cursor: pointer;
 +
  top: 0;
 +
  left: 0;
 +
  right: 0;
 +
  bottom: 0;
 +
  background-color: #ccc;
 +
  -webkit-transition: .4s;
 +
  transition: .4s;
 +
}
 +
 +
 +
.slider:before {
 +
  position: absolute;
 +
  content: "";
 +
  height: 26px;
 +
  width: 26px;
 +
  left: 4px;
 +
  bottom: 4px;
 +
  background-color: white;
 +
  -webkit-transition: .4s;
 +
  transition: .4s;
 +
}
 +
 +
input:checked + .slider.bluecolorbutton {
 +
  background-color: #2196F3;
 +
}
 +
 +
input:focus + .slider.bluecolorbutton {
 +
  box-shadow: 0 0 1px #2196F3;
 +
}
 +
 +
input:checked + .slider.redcolorbutton {
 +
  background-color: #FF0000;
 +
}
 +
 +
input:focus + .slider.redcolorbutton {
 +
  box-shadow: 0 0 1px #FF0000;
 +
}
 +
 +
 +
 +
input:checked + .slider:before {
 +
  -webkit-transform: translateX(26px);
 +
  -ms-transform: translateX(26px);
 +
  transform: translateX(26px);
 +
}
 +
 +
/* Rounded sliders */
 +
.slider.round {
 +
  border-radius: 34px;
 +
}
 +
 +
.slider.round:before {
 +
  border-radius: 50%;
 +
}
 +
input[type=text] {
 +
    width: 100%;
 +
    padding: 12px 20px;
 +
    margin: 8px 0;
 +
    box-sizing: border-box;
 +
    border: 3px solid #ccc;
 +
    -webkit-transition: 0.5s;
 +
    transition: 0.5s;
 +
    outline: none;
 +
}
 +
input[type=text]:focus {
 +
    border: 3px solid #555;
 +
}
 +
</style>
 +
<script>
 +
$(function () {
 +
    var rightVal = -150;
 +
   
 +
        $("#clickme").click(function () {
 +
       
 +
        rightVal = (rightVal * -1) - 150;
 +
        $(this).parent().animate({right: rightVal + 'px'}, {queue: false, duration: 500});
 +
    });
 +
   
 +
});
 +
 +
 +
 +
</script>
 +
 +
 +
</body>
  
 
</html>
 
</html>

Revision as of 08:24, 14 October 2016

Model - TAS Taipei iGEM Wiki




C◎UNTERACTS

Proof of Concept

Research


Professional Help

In order to improve how we develop our prototype we needed to get in contact with experts in the fields of eye surgery and cataracts research. Our first step was to contact eye doctors to discuss any problems associated with current cataracts treatment. Finally, while developing our project we realized that cataracts is a major issue in pets and other animals as well as people. As a result, we contacted local veterinarians to discuss what pet owners do when their pets contract cataracts. As our project developed, we needed more specific information regarding our genes of interest, cataracts development, and our delivery mechanism. We contacted scientists doing research similar to our own to get their opinion on our projects progress.




Contact with Eye Doctors

Eye doctors are on the front lines, delivering cataracts surgery, some privately and others for charity in organizations such as the Himalayan Cataracts Projects. We contacted local Taiwanese Eye Doctors to ask them about cataracts surgery. Here is a list of the doctors we contacted along with the information they provided:


Dr. Wei-Chi Wu is a retina specialist and an associate professor at Chang Gung memorial hospital in Taiwan. According to Dr. Wu current cataracts surgery methods are efficient and effective, but are not without their issues. Besides the issue of price, there can also be several different post-surgery complications such as infection, hemorrhaging, or secondary glaucoma. In regards to our project, he said one of the biggest issues we would face is non-invasive delivery. Currently, injections and incisions are the only methods for delivery because all current potential methods of noninvasive delivery either lack efficiency or induce with side effects.

Figure X. Full Construct.


Citations












Prevention

GSR Eyedrop

Treatment

25HC Eyedrop

LOCS: 0      


Eyedrops




× The tutorial is disabled.          
Turn off prevention eyedrops to activate the animation. For a full tutorial, click the question mark.