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| − | <p>While the biotechnology industry has progressed greatly, the benefits remain inaccessible to large populations, due to factors such as R&D, infrastructure costs, etc.
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| − | Our project develops tools and methodologies to broadly help with the last issue – the infrastructure costs, especially for biotech entrepreneurship. To achieve this, we focussed on genetically modifying E coli in order to automate as many processes in bioreactor operation and post-fermentation processing as possible, and came up with:
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| − | (i) Over-express proteins under regulation of an internal quorum sensing system instead of external induction, to save on costs and eliminate necessity to monitor cell density.
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| − | (ii) Achieve inducible and reversible inter-cell adhesion to allow for aggregation and separation of cell from media dependent on nutrient content in the media, to save costs on centrifugation.
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| − | (iii) A large fraction of the cells are removed, the cells deaggregated and fresh media added, returning the system to its initial state.
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| − | </p>
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