Difference between revisions of "Team:Toulouse France"

 
(128 intermediate revisions by 3 users not shown)
Line 4: Line 4:
 
<html>
 
<html>
  
 
<!-- End Top Background Image Wrapper -->
 
 
<!-- ################################################################################################ -->
 
<!-- ################################################################################################ -->
 
<!-- ################    CORPS DE LA PAGE ######################################## -->
 
<div class="column full_size">
 
<div class="hoc container clear">
 
 
<p align="justify" style="font-size:15px; padding: 15px 50px;">
 
 
<b style="font-size:16px;">Introduction</b>
 
 
<br>
 
<br>
 
Just like in many countries, prehistorical men walked into our lands.
 
However, they left a trace of their passage in France: the Lascaux cave, which is one of the most important heritages we have.
 
What is so specific about this cave ?
 
<br>it is not just a simple cave, cold, rocky and moist. The Lascaux cave is so much more.
 
<br>Decorated with organic and minerals pigments, it is home to parietal paintings and many frescoes and engravings cover the walls.
 
<br>Bulls, aurochs and horses are part of these representations, and testify the way of life of our ancestors.
 
  
<br>
+
<div class="page" style="height:auto; background-image:url('https://static.igem.org/mediawiki/2016/4/43/Toulouse_France_PanneauEmpreinte.jpg');">
<br>
+
<b style="font-size:16px;">Background - the historic of the cave</b>
+
<br>
+
<br>
+
As soon as the cave was discovered in 1940, people came from the whole country and abroad to visit it. However, the carbon dioxide and the water vapour released by their breath started to disrupt the cave’s ecosystem. The damages caused by these air changements are at the origin of the first crisis that the Lascaux cave knew. Two kinds of contaminations were observed: the limestone formation on the walls, which was called the white disease, and the green algae growth, named the green disease.
+
Then, white mold and black stains appeared on the walls and the floor, and were characteristical of the second and the third crisis respectively. These contaminations flow from fungi and bacteria proliferation.
+
<br>
+
<br>
+
<b style="font-size:16px;">Treatment of the cave</b>
+
<br>
+
<br>
+
Curing the cave was a priority. Consequently, treatments like biocid or antibiotics were tried.
+
The success of these initiatives worked temporarily, but new microorganisms developed on the organic wastes.
+
According to the last reviews about the Lascaux cave, bacteria (Bacillus subtilis, Pseudomonas species, Rhizobium radiobacter,...) and fungi (Fusarium sp., Ochroconis anomalaand,  Aspergillus sp., Acremonium sp.,...) are currently in the cave.
+
Nowadays, even if the cave situation is steady, microorganisms covering frescoes are still present.
+
<br>
+
<br>
+
<b style="font-size:16px;">Why did we choose this subject?</b>
+
<br>
+
<br>
+
At the beginning of the iGEM adventure, almost twenty subjects were considered.
+
Every thematic was intertwined with the other, like environment, health, and mostly art.
+
After months of intense brainstorming, we finally decided to work on the conservation of the Lascaux cave.
+
We wanted to choose a project that was personal and original.
+
The Lascaux cave then imposed itself.
+
It is part of the French heritage, and was added to the UNESCO World Heritage Sites list.
+
It has been threatened of destruction since decades now, and organizations from all around the world have gathered to solve the Lascaux cave crisis.
+
<br>The Lascaux cave is what traces us back to our humanity.
+
<br>The first men lived there and some of the first pieces of art ever were created there.
+
<br>
+
<br>
+
</p>
+
  
<center><a class="button-home" href="https://2016.igem.org/Team:Toulouse_France/Description" style="border: 1px solid #282828;-webkit-border-radius: 5px;-moz-border-radius: 5px;border-radius: 5px; padding: 13px 25px 12px; color: #282828; text-decoration: none; font-size: 17px; background: none; display: block; width: 89px;">Learn more</a>
+
<center><img src="https://static.igem.org/mediawiki/2016/1/19/Toulouse_France_logo2.png" style="width:30%; margin: 200px auto;"></center>
 +
 +
 +
<div style="background-color:rgba(1,1,1,0.9); float:bottom;">
 +
<center>
 +
<br>
 +
<font color="white"><p style="text-align:center; font-size:18px; vertical-align:middle;">iGEM Toulouse Team presents<br><i>Paleotilis, a shield for the Lascaux cave</i>
 +
<br><br> Back to the origins<br><br><p></font>
 +
</center>
 +
</div>
 +
</div>
  
</div>
 
</div>
 
 
 
 
 
 +
<!-- End Top Background Image Wrapper -->
 
 
 +
<!-- ################################################################################################ -->
 +
<!-- ################################################################################################ -->
 +
<!-- ################    CORPS DE LA PAGE ######################################## -->
  
 +
 +
 +
<div class="column full_size">
 +
<article align="justify;"  style="margin:10px 30px;">
 +
<br><b style="font-size:18px;">What if iGEM stepped 18,000 years back? </b>
 +
<br><br>At that time, cavemen painted extraordinary frescoes on the Lascaux cave (France). The cave remained stable until its discovery in 1940, which deeply disturbed its ecosystem. It was closed shortly after mainly because of contamination by fungi that causes colored spots on the frescoes. Nowadays, mechanical and chemical solutions are monthly used and the cave is still in danger due to their limited efficiency. <br>
 +
<br><br>At iGEM Toulouse, we thought about an innovative biological solution based on the last advances in synthetic biology. It consists in an engineered <i>Bacillus subtilis</i> strain which grow on bacterial organisms present in the cave. It releases antifungals when in close viscinity of fungi. Since we care about environment, an inducible riboswitch-based double toxin/antitoxin system was created to prevent DNA transmission and a physical device was designed to confine our strain.
 +
</article>
 +
</div>
 
 
<div class="clear"></div>
+
<div class="clear"></div>
  
<div class="gallerie-project">
+
<div class="gallerie-project">
  
<div class="line-gallerie-project">
+
<div class="line-gallerie-project">
<a href="https://2016.igem.org/Team:Toulouse_France/Description" class="part-little-projet">
+
<a href="https://2016.igem.org/Team:Toulouse_France/Context" class="part-little-projet">
<div class="title-part-projet">Project</div>
+
<div class="title-part-projet" style="text-align:center;">Project</div>
<div style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px;">vfbvgfbbrgb</div>
+
<div style="text-align:justify; word-wrap: break-word;position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:80%; line-height:24px;">Discover the context of the <b>Paleotilis</b> project, and the three modules of its design: <b>Predation</b>, <b>Antifungals</b>, and <b>Confinement</b>. Click on the link to learn more about these constructions.<br><br></div>
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:25px; right:22px; font-size:16px;">Read more</div>
+
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:25px; right:22px; font-size:16px;">Read more</div>
</a>
+
</a>
  
<a class="part-large-projet" style="background: url('https://static.igem.org/mediawiki/2016/4/45/Toulouse_France_LascauxVache.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
+
<a class="part-large-projet" style="background: url('https://static.igem.org/mediawiki/2016/4/45/Toulouse_France_LascauxVache.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
<div class="title-part-projet" style="color:white; ">Paleotilis</div>
+
<div class="title-part-projet" style="color:white; "></div>
<div style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px;">description 1 ligne</div>
+
<div style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px;"></div>
</a>
+
</a>
</div>
+
</div>
  
<div class="line-gallerie-project">
+
<div class="line-gallerie-project">
<a class="part-large-projet" style="background: url('https://static.igem.org/mediawiki/2016/4/4b/Toulouse_France_LascauxFresqueTaureaux.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
+
<a class="part-large-projet" style="background: url('https://static.igem.org/mediawiki/2016/4/4b/Toulouse_France_LascauxFresqueTaureaux.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
<div class="title-part-projet" style="color:white;">????</div>
+
<div class="title-part-projet" style="color:white;"></div>
<div style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px">but nkjsndvjnfduvnfduvnf</div>
+
<div style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px"></div>
</a>
+
</a>
  
<a href="https://2016.igem.org/Team:Toulouse_France/Demonstrate" class="part-little-projet">
+
<a href="https://2016.igem.org/Team:Toulouse_France/Experiments" class="part-little-projet">
<div class="title-part-projet">Results</div>
+
<div class="title-part-projet" style="text-align:center;">Results</div>
<div  style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px">To develop a predictive model</div>
+
<div  style="text-align:justify;  word-wrap: break-word; position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:80%; line-height:24px">The different biobricks we constructed have been tested to measure their efficiency. There you will have an overview of the results.<br></div>
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:28px; left:34px; font-size:16px;">Read more</div>
+
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:28px; left:34px; font-size:16px;">Read more</div>
</a>
+
</a>
</div>
+
</div>
  
<div class="line-gallerie-project">
+
<div class="line-gallerie-project">
<a href="https://2016.igem.org/Team:Toulouse_France/Human_Practices" class="part-little-projet">
+
<a href="https://2016.igem.org/Team:Toulouse_France/Human_Practices" class="part-little-projet">
<div class="title-part-projet">Human Practices</div>
+
<div class="title-part-projet" style="text-align:center;">Human Practices</div>
<div  style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px">but njsqkchuidshCUDB</div>
+
<div  style="text-align:justify;  word-wrap: break-word; position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:80%; line-height:24px">Lot of projects and events have been done by the iGEM Toulouse team. We aimed <b>to explain synthetic biology, to debate about the use of GMOs and to transmit what we have learnt</b>.<br><br></div>
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:25px; right:34px; font-size:16px;">Read more </div>
+
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:25px; right:34px; font-size:16px;">Read more </div>
</a>
+
</a>
  
<a class="part-large-projet" style="background:url('https://static.igem.org/mediawiki/2016/0/0a/Toulouse_France_LascauxPetitsChevaux.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
+
<a class="part-large-projet" style="background:url('https://static.igem.org/mediawiki/2016/0/0a/Toulouse_France_LascauxPetitsChevaux.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
<div class="title-part-projet" style="color:white; position:absolute; right:30px;  text-align:right;  line-height:24px;">??????</div>
+
<div class="title-part-projet" style="color:white; position:absolute; right:30px;  text-align:right;  line-height:24px;"></div>
<div style="position:absolute; top:90px; right:30px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px; text-align:right; ">but unhcuhsquchuids</div>
+
<div style="position:absolute; top:90px; right:30px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px; text-align:right; "></div>
</a>
+
</a>
</div>
+
</div>
  
</div>
+
</div>
  
  
 
 
 
 
 
<div class="column full_size">
 
 
 
To virtually visit the Lascaux cave !
 
http://www.lascaux.culture.fr/#/fr/00.xml
 
 
 
 
</div>
 
 
 
 
<div class="column full_size">
 
presse !
 
 
</div>
 
 
 
 
 
</body>
 
</body>
 
 
  
 
</html>
 
</html>
 +
 +
{{Toulouse_France/Sponsors}}
  
 
{{Toulouse_France/Footer}}
 
{{Toulouse_France/Footer}}

Latest revision as of 20:11, 19 October 2016

iGEM Toulouse 2016


iGEM Toulouse Team presents
Paleotilis, a shield for the Lascaux cave

Back to the origins


What if iGEM stepped 18,000 years back?

At that time, cavemen painted extraordinary frescoes on the Lascaux cave (France). The cave remained stable until its discovery in 1940, which deeply disturbed its ecosystem. It was closed shortly after mainly because of contamination by fungi that causes colored spots on the frescoes. Nowadays, mechanical and chemical solutions are monthly used and the cave is still in danger due to their limited efficiency.


At iGEM Toulouse, we thought about an innovative biological solution based on the last advances in synthetic biology. It consists in an engineered Bacillus subtilis strain which grow on bacterial organisms present in the cave. It releases antifungals when in close viscinity of fungi. Since we care about environment, an inducible riboswitch-based double toxin/antitoxin system was created to prevent DNA transmission and a physical device was designed to confine our strain.




Contacts