Difference between revisions of "Team:Toulouse France"

 
(568 intermediate revisions by 3 users not shown)
Line 1: Line 1:
−
{{Toulouse_France_TEST1}}
+
{{Toulouse_France}}
 +
{{Toulouse_France/menu}}
  
 
<html>
 
<html>
  
−
<head>
 
−
  <meta charset="utf-8">
 
−
  <title>iGEM Toulouse 2016</title>
 
−
  <link rel="icon" href="https://2016.igem.org/File:Toulouse_France_taureaux.jpg" type="image/jpg" style="width:10%;"/>
 
−
</head>
 
  
−
<!-- ################################################################################################ -->
+
<div class="page" style="height:auto; background-image:url('https://static.igem.org/mediawiki/2016/4/43/Toulouse_France_PanneauEmpreinte.jpg');">
−
<!-- ################################################################################################ -->
+
−
<!-- ################################################################################################ -->
+
  
−
<body>
+
<center><img src="https://static.igem.org/mediawiki/2016/1/19/Toulouse_France_logo2.png" style="width:30%; margin: 200px auto;"></center>
 +
 +
 +
<div style="background-color:rgba(1,1,1,0.9); float:bottom;">
 +
<center>
 +
<br>
 +
<font color="white"><p style="text-align:center; font-size:18px; vertical-align:middle;">iGEM Toulouse Team presents<br><i>Paleotilis, a shield for the Lascaux cave</i>
 +
<br><br> Back to the origins<br><br><p></font>
 +
</center>
 +
</div>
 +
</div>
  
−
  /* URL OF THE PAGE */
+
 +
<!-- End Top Background Image Wrapper -->
 +
 +
<!-- ################################################################################################ -->
 +
<!-- ################################################################################################ -->
 +
<!-- ################    CORPS DE LA PAGE ######################################## -->
  
−
  <script>
 
−
  var myurl = "https://2016.igem.org/Team:Toulouse_France";
 
−
  var elementId= "home";
 
−
  </script>
 
  
−
</html>
 
−
 
−
<!-- ################################################################################################ -->
 
−
<!-- ################################################################################################ -->
 
−
<!-- ################################################################################################ -->
 
−
 
−
{{Toulouse/nav}}
 
−
 
−
<html>
 
−
 
−
<!-- ################################################################################################ -->
 
−
<!-- ################################################################################################ -->
 
−
<!-- ################################################################################################ -->
 
−
<div class="wrapper row0 bgded" style="background-image:url('https://static.igem.org/mediawiki/2015/b/ba/TLSE_bg_2.png');">
 
−
  <div class="shout">
 
−
    <!-- ################################################################################################ -->
 
−
    <div class="shout-content clear" id="context">
 
−
<center><img src="https://static.igem.org/mediawiki/2015/2/2e/TLSE_ApiColi.png" style="width:30%;"></center>
 
−
 
 
−
<p class="center" style="font-size:15px;"><i>"Beware varroa: Apicoli is guarding the beehive!"
 
−
  </i>
 
−
  </p>
 
−
      <p class="fl_right"><a class="btn" href="#"  style="color: rgba(0,0,0,0)"> Easter egg </a></p>
 
−
    <br>
 
 
 
 +
<div class="column full_size">
 +
<article align="justify;"  style="margin:10px 30px;">
 +
<br><b style="font-size:18px;">What if iGEM stepped 18,000 years back? </b>
 +
<br><br>At that time, cavemen painted extraordinary frescoes on the Lascaux cave (France). The cave remained stable until its discovery in 1940, which deeply disturbed its ecosystem. It was closed shortly after mainly because of contamination by fungi that causes colored spots on the frescoes. Nowadays, mechanical and chemical solutions are monthly used and the cave is still in danger due to their limited efficiency. <br>
 +
<br><br>At iGEM Toulouse, we thought about an innovative biological solution based on the last advances in synthetic biology. It consists in an engineered <i>Bacillus subtilis</i> strain which grow on bacterial organisms present in the cave. It releases antifungals when in close viscinity of fungi. Since we care about environment, an inducible riboswitch-based double toxin/antitoxin system was created to prevent DNA transmission and a physical device was designed to confine our strain.
 +
</article>
 
</div>
 
</div>
−
 
+
−
  <!-- ################################################################################################ -->
+
<div class="clear"></div>
−
  </div>
+
−
</div>
+
−
<!-- ################################################################################################ -->
+
−
<!-- ################################################################################################ -->
+
−
<!-- ################################################################################################ -->
+
  
−
<div class="wrapper row3">
+
<div class="gallerie-project">
−
<br>
+
−
  <main class="container clear">
+
−
 
+
−
    <h2 ><center><img src=" https://static.igem.org/mediawiki/2015/f/f8/TLSE_ApiColi_Logo.png" style="width:33%;" /></center></h2>
+
−
    <!-- container body -->
+
−
    <!-- ################################################################################################ -->
+
−
   
+
−
<div class="group center">
+
−
        <p align="justify" style="font-size:15px;">
+
  
−
<i>Apis mellifera</i>, the most efficient and widespread honey producing species, is heavily affected by the mite <i>Varroa destructor</i>.
+
<div class="line-gallerie-project">
−
This pathogen is actually one of the most important cause of death for domestic bees. Indeed, according to beekeepers, up to 50% of
+
<a href="https://2016.igem.org/Team:Toulouse_France/Context" class="part-little-projet">
−
the swarms can be lost every year because of this parasite, causing tremendous economic damages.<br><br>
+
<div class="title-part-projet" style="text-align:center;">Project</div>
 +
<div style="text-align:justify; word-wrap: break-word;position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:80%; line-height:24px;">Discover the context of the <b>Paleotilis</b> project, and the three modules of its design: <b>Predation</b>, <b>Antifungals</b>, and <b>Confinement</b>. Click on the link to learn more about these constructions.<br><br></div>
 +
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:25px; right:22px; font-size:16px;">Read more</div>
 +
</a>
  
 +
<a class="part-large-projet" style="background: url('https://static.igem.org/mediawiki/2016/4/45/Toulouse_France_LascauxVache.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
 +
<div class="title-part-projet" style="color:white; "></div>
 +
<div style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px;"></div>
 +
</a>
 +
</div>
  
−
</p>
+
<div class="line-gallerie-project">
−
      </div>
+
<a class="part-large-projet" style="background: url('https://static.igem.org/mediawiki/2016/4/4b/Toulouse_France_LascauxFresqueTaureaux.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
−
 
+
<div class="title-part-projet" style="color:white;"></div>
−
  <div class="group center">
+
<div style="position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px"></div>
−
     
+
</a>
−
      <div class="one_third first">
+
−
       
+
−
<p align="center" style="font-size:50px;">35%<br></p>
+
−
<p align="center" style="font-size:15px;">Percentage of hives disapearing every year in the US*</p>
+
−
      <li><a href="
+
−
https://inra-dam-front-resources-cdn.brainsonic.com/ressources/afile/257834-38b5f-resource-dossier-abeilles.html#page=4
+
−
">*INRA</a></li>
+
−
      </div>
+
−
 
+
−
      <div class="one_third">
+
−
       
+
−
        <p align="center" style="font-size:50px;">70%<br></p>
+
−
<p align="center" style="font-size:15px;">Honey production loss in France since 1995*</p>
+
−
<li><a href="
+
−
http://www.unaf-apiculture.info/presse/Dossier%20de%20presse/DOSSIER_DE_PRESSE_UNAF.pdf#page=7
+
−
">*UNAF</a></li>
+
−
      </div>
+
−
 
+
−
      <div class="one_third">
+
−
       
+
−
        <p align="center" style="font-size:50px;">30,000<br></p>
+
−
<p align="center" style="font-size:15px;">
+
−
Number of hives lost every year in France since 1995*</p>
+
−
<li><a href="
+
−
http://www.unaf-apiculture.info/presse/Dossier%20de%20presse/DOSSIER_DE_PRESSE_UNAF.pdf#page=9
+
−
">*UNAF</a></li>
+
−
      </div>
+
−
 
+
−
 
+
−
    </div>
+
−
 
+
  
−
<br>
+
<a href="https://2016.igem.org/Team:Toulouse_France/Experiments" class="part-little-projet">
−
<div class="group center">
+
<div class="title-part-projet" style="text-align:center;">Results</div>
−
<p align="justify" style="font-size:15px;">
+
<div  style="text-align:justify;  word-wrap: break-word; position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:80%; line-height:24px">The different biobricks we constructed have been tested to measure their efficiency. There you will have an overview of the results.<br></div>
−
Our team is committed to preserving honeybees by limiting infection of beehives by these mites.
+
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:28px; left:34px; font-size:16px;">Read more</div>
−
The aim of our project is to create a bacterium able to bait and eliminate the parasite using the
+
</a>
−
Synthetic Biology tools and philosophy. The engineered bacterium, named ApiColi, will be safely placed in a trap and will express alternatively an attractant molecule and a poison for the <i>Varroa destructor</i>, in agreement with the honeybee life cycle. Our trap will be sealed to avoid any contact of the microorganism with the bees and the environment. We hope that our concept will help to reduce the decrease in bee populations and its disastrous consequences.<br><br><br><br>
+
</div>
−
</p>
+
−
</div>
+
  
−
+
<div class="line-gallerie-project">
−
+
<a href="https://2016.igem.org/Team:Toulouse_France/Human_Practices" class="part-little-projet">
−
+
<div class="title-part-projet" style="text-align:center;">Human Practices</div>
−
<center>
+
<div style="text-align:justify;  word-wrap: break-word; position:absolute; top:90px; left:34px; color:white; font-family:'Open Sans'; font-size:16px; width:80%; line-height:24px">Lot of projects and events have been done by the iGEM Toulouse team. We aimed <b>to explain synthetic biology, to debate about the use of GMOs and to transmit what we have learnt</b>.<br><br></div>
−
<div class="title" id="achievements">
+
<div style="border-bottom: 1px solid #fff; color:white; font-family:'Open Sans'; position:absolute; bottom:25px; right:34px; font-size:16px;">Read more </div>
−
  <h3><strong>Achievements</strong></h3>
+
</a>
−
  </div>
+
−
</center>
+
−
+
−
<table>
+
−
<tbody>
+
−
<tr>
+
−
<td style="width:50px">
+
−
<center>
+
−
<img src="https://static.igem.org/mediawiki/2015/4/41/TLSE_Home_Medals_Bronze.PNG" style="width:100%;" />
+
−
</center>
+
−
</td>
+
−
   
+
−
<td colspan="3">
+
−
 
+
−
  <ul><h3><strong>Bronze medal</strong></h3></ul>
+
−
 
+
−
</td>
+
−
</tr>
+
−
</tbody>
+
−
</table>
+
  
 +
<a class="part-large-projet" style="background:url('https://static.igem.org/mediawiki/2016/0/0a/Toulouse_France_LascauxPetitsChevaux.png') no-repeat center;-webkit-background-size: cover;-moz-background-size: cover;-o-background-size: cover;background-size: cover;">
 +
<div class="title-part-projet" style="color:white; position:absolute; right:30px;  text-align:right;  line-height:24px;"></div>
 +
<div style="position:absolute; top:90px; right:30px; color:white; font-family:'Open Sans'; font-size:16px; width:200px; line-height:24px; text-align:right; "></div>
 +
</a>
 +
</div>
  
 +
</div>
  
−
<ul><ul><ul>
 
−
<ul align="justify" style="font-size:15px;">
 
−
<li>Register to iGEM </li>
 
−
<li>Complete <a target="blank" href="https://igem.org/2015_Judging_Form?id=1587"> judging form</a></li>
 
−
<li>Wiki & Registry (from <a target="blank" href="https://2015.igem.org/Team:Toulouse/Parts">BBa_K1587000 to BBa_K1587009</a>)</li>
 
−
<li>Participate to Giant Jamboree </li>
 
−
<li><a target="blank" href="https://2015.igem.org/Team:Toulouse/Attributions"> Attributions:</a> our project could be
 
−
possible thanks to several persons who helped us in different ways and we are very grateful</li>
 
−
<li>Add new BioBrick to the Registry: <a target="blank" href="http://parts.igem.org/Part:BBa_K1587004"> BBa_K1587004</a> corresponds to <a target="blank" href="https://2015.igem.org/Team:Toulouse/Description/Attract#part3"> butyrate pathway</a> </li>
 
−
</ul>
 
−
</ul></ul></ul>
 
−
<br><br>
 
−
 
−
 
−
<table>
 
−
<tbody>
 
−
<tr>
 
−
<td style="width:50px">
 
−
<center>
 
−
<img src="https://static.igem.org/mediawiki/2015/2/2c/TLSE_Home_Medals_Silver.PNG" style="width:100%;" />
 
−
</center>
 
−
</td>
 
−
 
−
<td colspan="3">
 
−
 
 
−
  <ul><h3><strong>Silver medal</strong></h3></ul>
 
−
 
 
−
</td>
 
−
</tr>
 
−
</tbody>
 
−
</table>
 
  
 +
</body>
 +
  
−
<ul><ul><ul>
+
</html>
−
<ul align="justify" style="font-size:15px;">
+
−
<li>New BioBrick validated experimentally: <a target="blank" href="http://parts.igem.org/Part:BBa_K1587007"> BBa_K1587007</a> corresponds to <a target="blank" href="https://2015.igem.org/Team:Toulouse/Description/Eradicate#part2">formate pathway</a> </li>
+
−
<li>BioBrick <a target="blank" href="http://parts.igem.org/Part:BBa_K1587007"> BBa_K1587007</a> submitted to the Registry</li>
+
−
<li>Strong commitment to <a target="blank" href="https://2015.igem.org/Team:Toulouse/Practices">Practices:</a> Ethics, Safety, IP rights, Education </li>
+
−
+
−
</ul>
+
−
</ul></ul></ul>
+
−
<br><br>
+
−
+
−
+
−
<table>
+
−
<tbody>
+
−
<tr>
+
−
<td style="width:50px">
+
−
<center>
+
−
<img src="https://static.igem.org/mediawiki/2015/b/b0/TLSE_Home_Medals_Gold.PNG" style="width:100%;" />
+
−
</center>
+
−
</td>
+
−
+
−
<td colspan="3">
+
−
 
+
−
  <ul><h3><strong>Gold medal</strong></h3></ul>
+
−
 
+
−
</td>
+
−
</tr>
+
−
</tbody>
+
−
</table>
+
  
 +
{{Toulouse_France/Sponsors}}
  
−
<ul><ul><ul>
+
{{Toulouse_France/Footer}}
−
<ul align="justify" style="font-size:15px;">
+
−
+
−
<li>Innovative human practices: </li>
+
−
<ul>
+
−
<strong>-</strong> Active participating in <a target="blank" href="https://2015.igem.org/Team:Toulouse/Practices#Exp2">ExpoScience international</a> in Brussels and future <a target="blank" href="https://2015.igem.org/Team:Toulouse/Practices#Exc">exciting perspectives</a><br>
+
−
<strong>-</strong> Our project is based on a <b>deep</b><a target="blank" href="https://2015.igem.org/Team:Toulouse/Practices#Ethical"> Ethical reflection</a><br>
+
−
<strong>-</strong> <a target="blank" href="https://2015.igem.org/Team:Toulouse/Practices#Press">Discussions with beekeepers</a> to fit the best with real issue<br>
+
−
<strong>-</strong> <a target="blank" href="https://2015.igem.org/Team:Toulouse/Practices#Com">Communication in Junior high school</a><br>
+
−
</ul>
+
−
<li><a target="blank" href="https://2015.igem.org/Team:Toulouse/Collaborations#collab">Collaborations:</a> </li>
+
−
<ul>
+
−
<strong>-</strong> Modelling with KU Leuven team: they helped us with a <a target="blank" href="https://2015.igem.org/Team:Toulouse/Modeling#part5">diffusion modeling</a> and we model <a target="blank" href="https://2015.igem.org/Team:KU_Leuven/Modeling/Toulouse"> metabolites production</a> for them<br>
+
−
<strong>-</strong> <a target="blank" href="https://2015.igem.org/Team:Toulouse/Collaborations#ankara">Survey with METU HS Ankara team:</a> they worked on varroas too, so we exchanged data from our respective country on varroas infestation <br>
+
−
</ul>
+
−
+
−
</ul>
+
−
</ul></ul></ul>
+
−
<br><br>
+
−
 
+
−
 
+
−
+
−
+
−
+
−
+
−
+
−
+
−
+
−
+
−
</div> 
+
−
+
−
+
−
    <!-- ################################################################################################ -->
+
−
    <!-- / container body -->
+
−
    <div class="clear"></div>
+
−
  </main>
+
−
</div>
+
−
<!-- ################################################################################################ -->
+
−
<!-- ################################################################################################ -->
+
−
<!-- ################################################################################################ -->
+
−
 
+
−
<!-- ################################################################################################ -->
+
−
<!-- ################################################################################################ -->
+
−
<!-- ########################### SPONSORS ###################################################################### -->
+
−
+
−
</html>{{Toulouse/sponsors}}<html>
+
−
 
+
−
<!-- ################################################################################################ -->
+
−
<!-- ################################################################################################ -->
+
−
<!-- #######################        FOOTER        ######################################################################### -->
+
−
 
+
−
</html>{{Toulouse/footer}}<html>
+
−
 
+
−
 
+
−
 
+
−
</body>
+
−
</html>
+

Latest revision as of 20:11, 19 October 2016

iGEM Toulouse 2016


iGEM Toulouse Team presents
Paleotilis, a shield for the Lascaux cave

Back to the origins


What if iGEM stepped 18,000 years back?

At that time, cavemen painted extraordinary frescoes on the Lascaux cave (France). The cave remained stable until its discovery in 1940, which deeply disturbed its ecosystem. It was closed shortly after mainly because of contamination by fungi that causes colored spots on the frescoes. Nowadays, mechanical and chemical solutions are monthly used and the cave is still in danger due to their limited efficiency.


At iGEM Toulouse, we thought about an innovative biological solution based on the last advances in synthetic biology. It consists in an engineered Bacillus subtilis strain which grow on bacterial organisms present in the cave. It releases antifungals when in close viscinity of fungi. Since we care about environment, an inducible riboswitch-based double toxin/antitoxin system was created to prevent DNA transmission and a physical device was designed to confine our strain.
Project
Discover the context of the Paleotilis project, and the three modules of its design: Predation, Antifungals, and Confinement. Click on the link to learn more about these constructions.

Read more
Results
The different biobricks we constructed have been tested to measure their efficiency. There you will have an overview of the results.
Read more
Human Practices
Lot of projects and events have been done by the iGEM Toulouse team. We aimed to explain synthetic biology, to debate about the use of GMOs and to transmit what we have learnt.

Read more



Contacts
    🏠 INSA Toulouse
    135, Avenue de Rangueil
    31077 TOULOUSE Cedex 4
    France
  • ☎ +00 (33) 6 13 64 89 40
  • ✉ igemtoulouse2016@gmail.com