Difference between revisions of "Team:BIT/Basic Part"

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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2016.igem.org/Judging/Awards#Special_Prizes">basic part special prize</a>. </p>
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<p> Delete this box in order to be evaluated for this medal. See more information at <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions"> Instructions for Pages for awards</a>.</p>
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<p>
 
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A <b>basic part</b> is a functional unit of DNA that cannot be subdivided into smaller component parts. <a href="http://parts.igem.org/wiki/index.php/Part:BBa_R0051">BBa_R0051</a> is an example of a basic part, a promoter regulated by lambda cl.
 
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</p>
 
  
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<p>Most genetically-encoded functions have not yet been converted to BioBrick parts. Thus, there are <b>many</b> opportunities to find new, cool, and important genetically encoded functions, and refine and convert the DNA encoding these functions into BioBrick standard biological parts. </p>
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<h4>Note</h4>
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<p>This page should list all the basic parts your team has made during your project. You must add all characterization information for your parts on the Registry. You should not put characterization information on this page.</p>
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<h4>PARTS</h4>
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<h1><font color=#c91f77>B</font>asic <font color=#c91f77>P</font>art</h1>
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    <li><a href="https://2016.igem.org/Team:BIT/Parts_Submission"><h2>Parts Submission</h2></a></li>
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    <li class=color1><a href="https://2016.igem.org/Team:BIT/Basic_Part"><h2>Basic Part</h2></a></li>
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    <li><a href="https://2016.igem.org/Team:BIT/Composite_Part"><h2>Composite Part</h2></a></li>
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<h2><br><br><br><br><br><br><br>Basic Part</h2>
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                <br>
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<img src="https://static.igem.org/mediawiki/2016/6/65/BIT_basic_part.jpg" class="img-responsive" alt="...">
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<div style="text-indent: 0em;">
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<center> <font size="1px">miRNA-155 binding site</font></center><br><br>
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</div>
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<p>MiRNAs are widely recognized as biomarkers of many diseases. Many studies have shown that, miRNA-155 in patients with breast cancer in the body was significantly higher than normal people. After a thorough literature review , we know the recognition site of miRNA-155, of which  the transcription product, mRNA and miRNA-155 base-specific complementary matching, in order to increase its binding specificity with miRNA-155, we design four binding sites for this part,  so that when the miRNA-155 presence, it can be quickly identified by this fragment and combine to form double-stranded mRNA complex, blocking the binding of ribosomes, which will inhibit the downstream gene expression, which is called RNA-based gene silencing expression. This can serve as a switch to regulate the expression of downstream genes.
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<strong>Address</strong><br>
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<br>
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Beijing Institute of Technology,<br>
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No. 5 South Zhong Guan Cun Street,<br>
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Haidian Beijing 100081, P. R. China<br><br>
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Twitter : @igem_BIT<br><br>
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Sina Weibo : @igem_BIT<br><br>
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Website : http://www.bit.edu.cn
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Latest revision as of 03:36, 20 October 2016

<!DOCTYPE html> Biology

PARTS

Basic Part








Basic Part


...
miRNA-155 binding site


MiRNAs are widely recognized as biomarkers of many diseases. Many studies have shown that, miRNA-155 in patients with breast cancer in the body was significantly higher than normal people. After a thorough literature review , we know the recognition site of miRNA-155, of which the transcription product, mRNA and miRNA-155 base-specific complementary matching, in order to increase its binding specificity with miRNA-155, we design four binding sites for this part, so that when the miRNA-155 presence, it can be quickly identified by this fragment and combine to form double-stranded mRNA complex, blocking the binding of ribosomes, which will inhibit the downstream gene expression, which is called RNA-based gene silencing expression. This can serve as a switch to regulate the expression of downstream genes.






Contact Us

Address

Beijing Institute of Technology,
No. 5 South Zhong Guan Cun Street,
Haidian Beijing 100081, P. R. China

Twitter : @igem_BIT

Sina Weibo : @igem_BIT

Website : http://www.bit.edu.cn
Send