Difference between revisions of "Team:Paris Saclay/HP/Gold"

Reminder Gold medal :
Expand on your silver medal activity by demonstrating how you have integrated the investigated issues into the design and/or execution of your project.

We chose to work on human practices directly linked with our project : because we were working with CRISPR-Cas9, we tried to know more about it and to learn how to use it in a responsible way.

We wanted this research to have a direct effect on our project. While working on the concept of Responsible Research and Innovation we had the idea to create a RRI Test, which works as a feed-back for the projects. The principles of Responsible Research and Innovation guided our research, and the RRI test helped us to reshape it to build a more responsible project. We thus integrated all our human practices on CRISPR-Cas9 by the bias of responsibility : the RRI worked as a tool to integrate our human practices in our project.

We filled our test to see how we responded to the principles we wanted to follow. This test is divided in four parts : Reflexivity, Anticipation, Inclusiveness/Deliberation, Responsiveness. We believe iGEM could be a great laboratory for this principles. Following this idea we gave the test to several team. They all filled it and we tried to see how the four axis of RRI (Reflexivity, Anticipation, Inclusiveness, Responsiveness are integrated by the teams.

What did we learn on our project ?

I/ Reflexivity

When we chose our project we had different options. We chose to take a fundamental project, riskier but more original.

Stakeholders were essential to help us build our project. They helped us to focus on many points and to put the project in perspective. We thus met many scientists, but also jurists and public.

Was our project needed ? We thought about the different applications of the project. It was not an easy task because the project is a fundamental one. We were guided by a publication of Olivier Espeli “From structure to function of bacterial chromosomes : evolutionary perspectives and ideas for new experiments”, which said a tool like ours would be useful for scientists (FEBS Letters, 2015). We find that our tool would be useful for biologists because of its simplicity, but also in health. This tool could indeed help to diagnose genetic diseases.

The impacts of our project were difficult to define, because it was a project fundamental biology : we didn’t know how it could be used. But the impacts of a responsible project can’t be only transferred to the user and his use in a environnemental or health context  ; science itself must be responsible.

With this reflexion came the main question the RRI test asked us : how RRI could apply to fundamental research, such as our project on CRISPR-Cas9 ? The societal goal doesn’t seem to exist. However, building a responsible research is in itself a societal goal : having a more responsible science is undoubtedly a benefit for the society. The stakeholders of a fundamental project are the ones whose voices are interesting and necessary on science. In other words, the stakeholders are less identified. On our focus on CRISPR-Cas9 we felt necessary to gather stakeholders and tried to draw with them the future of a responsible use on this technology.

II/ Anticipation

The more we knew about CRISPR-Cas9, the more we realised we didn’t know much on this technology and its impacts. The difficult anticipation in the scientific field transferred our questions on the human practice, and we try to learn from stakeholders what the burning issues can be on CRISPR-Cas9, and tried to get people know more about it.

III/ Inclusiveness/Deliberation

As our project was in the field of synthetic biology, we had a strong concern about inclusiveness. We met a lot of stakeholders and public. In our case of fundamental research we defined the stakeholders as scientists using CRISPR-Cas9 and counselors in industrial property.

POPULAR SCIENCE : A KEY CONCERN

As we believe popular science is a key concern in synthetic biology and especially for CRISPR-Cas9, we lead several activities in this field.

During a vox pop we saw that people were mostly unaware of synthetic biology itself. We thus tried to meet public, to discuss with us of synthetic biology, CRISPR and our project. (link of the vox pop ?)

We met students during an exposition in the Nanterre University, but also during the Festival Vivant, opened to everyone and an exposition at the Pays de Limours.

What did we learn of this experiments ? Most of the people we met trust scientist to be responsible in their use, and doesn’t feel legitimate to bring a critic on a subject they don’t master.

MEETING STAKEHOLDERS

CONFERENCE : THE SOCIETAL ISSUES OF CRISPR-CAS9

Because we had a strong concern both on vulgarisation and meeting stakeholders, we hold a conference in our university, in front of students, with two researchers, Jean Denis Faure, a researcher and teacher using CRISPR-Cas9 on plants, and Pierre Walrafen a scientific with a cellular biochemistry and patent engineer.

We tried with our guests to think about the societal issues of CRISPR-Cas9, for the ethics, the law and the economy. The ethical problems CRISPR-Cas9 is bringing are huge, and for most of them, unknown. The ethical problems comes with what is done with the technology : therapeutical applications ex vivo or for genetical diseases, or applications on embryos and germ cells. The ethical problems comes along with the question of transhumanism. The issues are rising because of the simplicity of CRISPR-Cas9, authorizing a wider scientific audience to edit the genome.

About the legal framework, our speakers made a comparison between the European legal framework, the process based evaluation, and the product based evaluation, and how the patentability was in Europe restrained by a principle of public order.

iGEM MEET-UPS

We attend to two iGEM meet-ups, an European one, and an other, gathering the Parisian teams. We were part of the organisation of the Parisian meet-up.

This meet-ups helps us in two ways. First it was a great opportunity to have a feed-back from our peers. Then, we met there other teams working with CRISPR-Cas9, and lead collaborations with them.

IV/ Responsiveness

What did we learn ?

Leading a project on fundamental biology involves to work a lot with stakeholders. In a RRI vision, a fundamental project is an opportunity to think about the responsability of science, in our case CRISPR-Cas9.

The we saw that the potentiality of CRISPR-Cas9 was huge. This leads to two things :

it’s very difficult to define precisely what could be the impacts, thus a harder work must be furnished on the subject.

vulgarisation for the public is a key issue.

CRISPR-Cas9 is easy to use, even by students and has big consequences. We should define the purposes with more rigor and strengthen the safety part.

Using CRISPR-Cas9 requires to know about the gene before we can mutate its functions. This requires to work on genes we already know about or to have a strong research on the gene.

In the ethical field we should always balance the advantages and the disadvantage. Even if it seems obvious, it is fundamental to do this and to present the balance to the public opinion.

★ ALERT!

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