Acknowledgements

We want to thank immensely all the people who provided us help and made this great project possible!

First of all, we thank the BMP school from Paris Saclay University, specially Gerald Peyroche for his vote of trust. The "Solidarity and Development of Student Initiatives Fund" (FSDIE) from Paris Sud University. The Institute of Integrative Biology of the Cell (I2BC) of Paris Saclay University. The Office for Science and Technology of the Embassy of France in the United States. The Villebon-Sharpak Institute of Paris Saclay for the financial support.

We also would like to thank for all donations that came from the following individuals sponsors: Estelle Robbe, Anne-Claire Guillongopaul, Santiago Jiménez Domínguez, Helène Costantin Viala, Mickaël Faria, René Chevalier, Ahmed Kabeche, Sylvain Djeyacoumar, François et Virginie Brenac, Henri-Dominique and Catherine Lacointa, Daniel and Claudine Schaffhauser, Sébastien Valadon, and Marie Rouquette.

We want to thank Biolabs, Takara and Clontech Company for supplying the lab material.

We want to thank all the I2BC's staff for helping us during the summer internship. A special thanks to Isabelle Hatin and Olivier Bugaud for guiding us through the cytometer technics. Emilie Drouineau and Claire Toffano-Nioche for all the support and advises on the modelling.

We would like to thank David Bikard, head of lab at the Institut Pasteur, Olivier Espéli, group leader at the Collège de France, Deshmuck Gopaul, group leader at the institut Pasteur for giving us support for the scientific backgroud of our projet.

We thank Agnès Ricroch, professor at AgroParisTech, Mr Eric Enderlin, French and European Patent Attorney at Novagraaf, and Marc Fellous, Emeritus Professor at Paris Diderot University and Medical Doctor, for having answered to our ethical questions.

We want to thank Mrs Geneviève Fioraso, French deputy and former ministry of Higer Education and research, and Catherine Procaccia, French Senator for taking time to talk with us about the impact of political decisions on scientific research.

We thank Pierre Walrafen, an European Patent Attorney, and, Jean Denis Faure, a researcher and professor at AgroParisTech school, our two nice speakers who tried to find answers to difficult questions about CRISPR-Cas9 techniques during the debate. We also want to thank the public for their participation.

We thank Stella Pacheco who helped us to set up our exhibiton on synthetic biology at the Nanterre university.

We thank Sylvain allemand for the interest shown on our project through the article he wrote in Paris Saclay media.

We want to thank Uriel Hazan and Pascale Rialland-Lefèvre, director and vice-director of Biology Department at the École normale supérieure de Paris-Saclay for their support and their avalibility.

We want to thank the Jean Monnet University of Sceaux and especially professor A. Ben Samoun and M (le doyen) A. Latreille

We thank Fabian Froehlich, our mentor for all the advise he gave us.

To finish we will never forget Maxime Schaffhauser, the best wiki designer, who helped us very much to create our romantic wiki!