Difference between revisions of "Team:IngenuityLab Canada/Practices"

Line 3: Line 3:
 
<div class="wrapper">
 
<div class="wrapper">
 
<h1>Human Practices 2016</h1>
 
<h1>Human Practices 2016</h1>
 +
<h2> Innovation in Disruptive Technologies </h2>
 
<p>
 
<p>
−
The main objective of a toolkit is to provide a readily accessible form of synthetic biology that is directed towards businesses and entrepreneurs. From this we extrapolated what it would take to possibly commercialize our product. We identified two issues that may arise as a result of our work.
+
DNA origami is an example of disruptive technology, where innovation impacts pre existing value networks and generates a new market place. The implications behind the technology are usually broad and leads to accelerated development of varied downstream technologies. For example, the dNANO project is an application of DNA origami that aims to create standardized nano circuits which builds off the work of DNA origami. After speaking to Dr.Ferguson Pell, a biomedical engineer at the University of Alberta, adoption of these new technologies are hampered by the cost and accessibility at the time. Both these factors make early adoption of innovation unfeasible and therefore growth in these areas are likewise slow. For example, the field of synthetic biology has become a recent field exploration due to disruptive innovations in low cost sequencing and nucleotide synthesis making it economically feasible for innovators to innovate.
−
</p><p>
+
</p>
−
The first issue is public perception. With disruptive technologies, progress increases exponentially as technical limitations are eliminated through prior innovations. Consequently, many of these new developments go unnoticed, and the only source of information that the public sees is from sensationalist news, usually denouncing the technology. Monsanto, for example, developed a new strain of wheat that was resistant to weed killer. Now farmers can simply spray their crop with pesticide without the fear of poisoning their harvest. The only issue is that, because Monsanto patented the crop, this gave the company legal control over the seed – and the ability to track if farmers were carrying seed over from last harvest. This clash between new innovations and traditional practices, and perceptions - coupled with the public’s uncertainty towards genetically modified organisms (GMOs) - gained Monsanto notoriety among its clientele.  
+
<p>
−
</p><p>
+
<div class="article-img">https://static.igem.org/mediawiki/2016/d/db/T--IngenuityLab_Canada--Matt1.jpg</div>
−
We planned to address this issue by educating the public about synthetic biology - to eliminate any scepticism they might have. We went to St. Elizabeth Seton and made a presentation on the topic, during which we demonstrated basic techniques – such as extracting DNA from strawberry plants – and introduced them to the innovations that have been made in recent history.
+
</p>
−
</p><p>
+
<p>
−
The second issue that must be addressed from a business perspective is intellectual rights. The development of new technologies always poses a question about who owns the property. As a potential venture, we have to discuss the overall concept of trademarking, copyrighting, and patenting the idea. These areas bring about a host of challenges ranging from jurisdiction to what actually compromises the property in question. To create a solid source of revenue for the venture it is necessary to define and understand the many layers involving Intellectual Property Rights.
+
Our team recognized limitations which made DNA origami difficult to work with such as abberent base pair interactions, a lack of readily accessible resources, a lack of standardized documentation for structure construction and a community that is able to foster exploration with DNA origami. So we aimed to develop an open source repository for DNA origami. Open sourcing is a model in which information is able to be shared amongst a developer community composed of early adopters and enthusiasts, the benefit being knowledge spreading leading to rapid development. We then played around with the idea of sending DNA origami as a biobrick as iGEM has its own infrastructure for open source development. However, after realising the biobrick standard was incompatible with DNA origami, we decided to create our own initiative, the DNA origami library. Our tentative library would serve as a catalogue of entries for DNA origami shapes.
−
</p><p>
+
</p>
−
To discuss and learn more about this issue we consulted TEC Edmonton, an economic development agency. With them we conducted a Q&A session to understand the potential property right issues when designing and developing new technologies.
+
<p> Each entry in the library will then contain the following:</p>
 +
                                                    <ol>
 +
                                                        <li>Sequence of the template strand</li>
 +
                                                        <li>Sequence of staples</li>
 +
                                                        <li>An in silico visualization of the structure</li>
 +
                                                        <li>A TEM of the actual structure</li>
 +
                                                        <li> A detailed protocol that was utilized in the constructions. Parameters such as oligo concentrations and incubations will be some of the mandatory requirements included in each entry </li>
 +
                                                        <li>Any other notes that may assist in reproducibility the structure folding</li>
 +
                                                    </ol>
 +
<p>
 +
Reproducibility is the main concern with many science based innovations and our hope is that with the DNA Origami library, we are able to cut down on time and resources spent troubleshooting with DNA origami construction, so that innovators can dedicate their energy innovating with DNA origami rather than making DNA origami. Our hope is that from this open source frame work, innovations with DNA origami can come about similar to how dNANO is an innovation in nano circuitry stemming off of DNA origami. However, with many innovations come the issue of ownership and intellectual property.  
 +
</p>
 +
<h2> Intellectual Property Rights</h2>
 +
<p>
 +
Intellectual property is described as any product, invention that has come about from the creative process and has the ability to be protected by a patent, copyright, trademark or any other form of legislative protection. With our novel innovation in DNA origami, dNANO, we wanted to know more about the legislation that is out there to ensure that any innovations from our open source initiative can be made ours. We consulted TEC Edmonton, a startup incubator for more information in regards to IP rights in determining what is protected under Canadian patent law. A patent is a method of protecting inventions in which the inventor discloses the details of the creation to the level of detail where another individual can replicate the device in place for exclusive rights to that invention for set amount of time. In Canada and the United States that time is 20 years. According to TEC, in order for an invention to be patentable it must demonstrate 3 attributes:
 +
</p>
 +
                                                    <ol>
 +
                                                        <li> Novelty- Is this invention/application the first of its kind?</li>
 +
                                                        <li> Usefulness- Does this invention show some sort of utility?</li>
 +
                                                        <li> Non obviousness- The invention must improve on existing technology that is not obvious. For example, one cannot patent a series of lightbulbs since it does not deviate enough from the base invention being the lightbulb.  
 +
</li>                                                 
 +
</ol>
 +
<p>
 +
Things that can be patented are concepts, inventions and applications of other products. In every patent is a state of claims made by the inventor, so long as there is enough evidence to demonstrate what is claimed in the patent then it has the potential to be patented. By doing so the patentee is claiming their creation is reasonably enabled. The team broke down the DNA origami aspect into three individual components: the template strand, the staple strands and the final structure which all can be patented.  
 
</p>
 
</p>
 
<p>
 
<p>
 
<div class="article-img">https://static.igem.org/mediawiki/2016/f/fa/T--IngenuityLab_Canada--TEC_Edmonton.png</div>
 
<div class="article-img">https://static.igem.org/mediawiki/2016/f/fa/T--IngenuityLab_Canada--TEC_Edmonton.png</div>
 
</p>
 
</p>
−
<h2>Intellectual Property Rights in Emerging Markets</h2>
 
 
<p>
 
<p>
−
Our human practices revolve around exploring the process of bringing our invention out from the lab into the market. In order to allow our technology to have access to a greater market share, one of the aspects we needed to address is protection of intellectual property not only in Canada but also in other emerging markets. We then contacted and collaborated with the Sichuan University (SCU-China) iGEM team in order to compare and contrast intellectual property rights in Canada and in China.  
+
As the act of patenting is costly, we were also introduced to the concept of strategic patenting. This practice ensures that the patentee has a much time as possible to work on their IP while being protected before fully committing economically to the patenting process. Since we will be disclosing the majority of out findings on the iGEM wiki in late October, the ability to file a patent in many international markets are limited as they immediately label any knowledge on the internet as public domain. For a patent in Canada/United States, there is a one-year grace period after the date of disclosure in order to file a patent before the IP becomes part of the public domain. During this time period, one can file for a provisional patent valid for Canada and the U.S, the function of the provisional patent is to serve as a place holder for a patent down the line and lasts for a year from the date of filing. After the 12 months, one can go straight into a U.S. patent which lasts 20 years or can file a Paris Convention Treaty Patent, which would extend protection by 18 months which allows for more time to get research funding, additional development and entrepreneurship.
−
</p><p>
+
</p>
−
There are two methods in how our IP could be protected. The first is keeping the template strand, staples and final structure a trade secret. In both countries, trade secrets are not protected under any formal jurisdiction, however, the benefit of keeping it so are that any technical information in regards to the invention do not have to be disclosed to the public. The only disadvantage is when a trade secret ceases to be a secret any monetary value associated with the technology is usually diminished.
+
<p>
−
</p><p>
+
<div class="article-img">https://static.igem.org/mediawiki/2016/6/6f/T--IngenuityLab_Canada--matt3.jpg</div>
 +
</p>
 +
 
 +
<p>
 +
As a team we were also curious to see how intellectual property rights in emerging markets affected patenting. The rationale behind this exploration was to explore intellectual property in other emerging markets and see whether or not dNANO could potentially commercialized. We then contacted and collaborated with the Sichuan University (SCU-China) iGEM team in order to compare and contrast intellectual property rights in Canada and in China.  
 +
</p>
 +
<p>
 +
We realized that some countries have compulsory licencing where the government is able to licence out one’s IP without prior consent of the inventor. Usually, these are granted under special circumstances such as a national emergency and ultimately undermines the inventor’s autonomy with the IP. P
 +
</p>
 +
<p>
 
Alternatively, dNANO could be patented which would prevent others from copying the design and the processes associated to building the nano moulds. Since our current mould design was based off the M13mp18 phage genome, the template DNA on its own cannot be patented. However, what is unique is the staples utilized to fold the template into the mould structure, as well as the final mould product. As a future direction, we plan on synthesizing our own unique template strand that could be protected, this in turn would make the development of dNANO from start to finish unique.  
 
Alternatively, dNANO could be patented which would prevent others from copying the design and the processes associated to building the nano moulds. Since our current mould design was based off the M13mp18 phage genome, the template DNA on its own cannot be patented. However, what is unique is the staples utilized to fold the template into the mould structure, as well as the final mould product. As a future direction, we plan on synthesizing our own unique template strand that could be protected, this in turn would make the development of dNANO from start to finish unique.  
 
</p><p>
 
</p><p>

Revision as of 00:54, 20 October 2016

Ingenuity Lab - dNANO

 

Human Practices 2016

Innovation in Disruptive Technologies

DNA origami is an example of disruptive technology, where innovation impacts pre existing value networks and generates a new market place. The implications behind the technology are usually broad and leads to accelerated development of varied downstream technologies. For example, the dNANO project is an application of DNA origami that aims to create standardized nano circuits which builds off the work of DNA origami. After speaking to Dr.Ferguson Pell, a biomedical engineer at the University of Alberta, adoption of these new technologies are hampered by the cost and accessibility at the time. Both these factors make early adoption of innovation unfeasible and therefore growth in these areas are likewise slow. For example, the field of synthetic biology has become a recent field exploration due to disruptive innovations in low cost sequencing and nucleotide synthesis making it economically feasible for innovators to innovate.

T--IngenuityLab_Canada--Matt1.jpg

Our team recognized limitations which made DNA origami difficult to work with such as abberent base pair interactions, a lack of readily accessible resources, a lack of standardized documentation for structure construction and a community that is able to foster exploration with DNA origami. So we aimed to develop an open source repository for DNA origami. Open sourcing is a model in which information is able to be shared amongst a developer community composed of early adopters and enthusiasts, the benefit being knowledge spreading leading to rapid development. We then played around with the idea of sending DNA origami as a biobrick as iGEM has its own infrastructure for open source development. However, after realising the biobrick standard was incompatible with DNA origami, we decided to create our own initiative, the DNA origami library. Our tentative library would serve as a catalogue of entries for DNA origami shapes.

Each entry in the library will then contain the following:

  1. Sequence of the template strand
  2. Sequence of staples
  3. An in silico visualization of the structure
  4. A TEM of the actual structure
  5. A detailed protocol that was utilized in the constructions. Parameters such as oligo concentrations and incubations will be some of the mandatory requirements included in each entry
  6. Any other notes that may assist in reproducibility the structure folding

Reproducibility is the main concern with many science based innovations and our hope is that with the DNA Origami library, we are able to cut down on time and resources spent troubleshooting with DNA origami construction, so that innovators can dedicate their energy innovating with DNA origami rather than making DNA origami. Our hope is that from this open source frame work, innovations with DNA origami can come about similar to how dNANO is an innovation in nano circuitry stemming off of DNA origami. However, with many innovations come the issue of ownership and intellectual property.

Intellectual Property Rights

Intellectual property is described as any product, invention that has come about from the creative process and has the ability to be protected by a patent, copyright, trademark or any other form of legislative protection. With our novel innovation in DNA origami, dNANO, we wanted to know more about the legislation that is out there to ensure that any innovations from our open source initiative can be made ours. We consulted TEC Edmonton, a startup incubator for more information in regards to IP rights in determining what is protected under Canadian patent law. A patent is a method of protecting inventions in which the inventor discloses the details of the creation to the level of detail where another individual can replicate the device in place for exclusive rights to that invention for set amount of time. In Canada and the United States that time is 20 years. According to TEC, in order for an invention to be patentable it must demonstrate 3 attributes:

  1. Novelty- Is this invention/application the first of its kind?
  2. Usefulness- Does this invention show some sort of utility?
  3. Non obviousness- The invention must improve on existing technology that is not obvious. For example, one cannot patent a series of lightbulbs since it does not deviate enough from the base invention being the lightbulb.

Things that can be patented are concepts, inventions and applications of other products. In every patent is a state of claims made by the inventor, so long as there is enough evidence to demonstrate what is claimed in the patent then it has the potential to be patented. By doing so the patentee is claiming their creation is reasonably enabled. The team broke down the DNA origami aspect into three individual components: the template strand, the staple strands and the final structure which all can be patented.

T--IngenuityLab_Canada--TEC_Edmonton.png

As the act of patenting is costly, we were also introduced to the concept of strategic patenting. This practice ensures that the patentee has a much time as possible to work on their IP while being protected before fully committing economically to the patenting process. Since we will be disclosing the majority of out findings on the iGEM wiki in late October, the ability to file a patent in many international markets are limited as they immediately label any knowledge on the internet as public domain. For a patent in Canada/United States, there is a one-year grace period after the date of disclosure in order to file a patent before the IP becomes part of the public domain. During this time period, one can file for a provisional patent valid for Canada and the U.S, the function of the provisional patent is to serve as a place holder for a patent down the line and lasts for a year from the date of filing. After the 12 months, one can go straight into a U.S. patent which lasts 20 years or can file a Paris Convention Treaty Patent, which would extend protection by 18 months which allows for more time to get research funding, additional development and entrepreneurship.

T--IngenuityLab_Canada--matt3.jpg

As a team we were also curious to see how intellectual property rights in emerging markets affected patenting. The rationale behind this exploration was to explore intellectual property in other emerging markets and see whether or not dNANO could potentially commercialized. We then contacted and collaborated with the Sichuan University (SCU-China) iGEM team in order to compare and contrast intellectual property rights in Canada and in China.

We realized that some countries have compulsory licencing where the government is able to licence out one’s IP without prior consent of the inventor. Usually, these are granted under special circumstances such as a national emergency and ultimately undermines the inventor’s autonomy with the IP. P

Alternatively, dNANO could be patented which would prevent others from copying the design and the processes associated to building the nano moulds. Since our current mould design was based off the M13mp18 phage genome, the template DNA on its own cannot be patented. However, what is unique is the staples utilized to fold the template into the mould structure, as well as the final mould product. As a future direction, we plan on synthesizing our own unique template strand that could be protected, this in turn would make the development of dNANO from start to finish unique.

However, one of the issues that arises from is the topic of compulsory licencing. This is where someone else can produce the same patented product without the consent of the patent holder while paying a fee. In China, compulsory licences are used in times of national emergencies the government may grant a compulsory license for use of an invention or utility model patent.

In contrast, according to Canadian intellectual property rights, compulsory licencing is generally utilized if the public benefits from the patented invention more so than reduced disclosure and innovation; and the public working in the patented invention outweigh the patentee’s private interests. Generally, this would be utilized to prevent monopolies.

Applying this information to our project, we realized that under special circumstances our intellectual property could be used by others without our consent in both countries. However, if we were to bring dNANO out as a venture, patenting our technology would be the best way to go. This is because a patent lasts 20 years in both countries and in those 20 years new dNANO parts can be created which could replace previous iterations of our moulds. Each new design could be patented, so as long new parts are developed within the 20 year time span, our intellectual property is protected. This will most likely be the case as the technical limitations hampering the scalability of DNA origami are overcome.

To read Laws on Intellectual Property Rights & Protection In Canada click here:

https://2016.igem.org/Team:IngenuityLab_Canada/Laws_Canada

To read Laws on Intellectual Property Rights & Protection In China click here:

https://2016.igem.org/Team:IngenuityLab_Canada/Laws_China