Team:IISc Bangalore/Model
Modeling
A model was constructed to find out the optimal conditions for the production of the protein of interest, which is controlled by quorum sensing. It was assumed that the synthesis of autoinducer molecules is negligible before the log phase in the bacterial growth curve kicks in, and also that after protein protein production begins, the cells practically stop dividing. An expression was found for the optimal ratio of the threshold autoinducer concentration to the rate of autoinducer synthesis to maximize the synthesis of the recombinant protein.
