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| − | <h1>Enhanced Wound Healing Using a Protein Infused Collagen Scaffold</h1> | + | <h1>Enhanced Wound Healing Using a Protein-Infused Collagen Scaffold</h1> |
| | <h2>Lubbock_TTU · Texas Tech University</h2> | | <h2>Lubbock_TTU · Texas Tech University</h2> |
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| − | </br></br><font size="6">Balance is Key</font></br></br>
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| − | Experience has most likely reinforced the idea that balance is key to health, happiness, and well-being. There are lessons to be learned depending on how we apply an understanding of balance to the nature of the process in question. Regarding the human body, scientists have made significant progress in understanding the balance of interactions in biochemical and physiological systems ever since Robert Hooke discovered the first cell in 1665. The vast complexity of interactions in the body between the cells and tissues have made studying how these systems work difficult, yet rewarding. When these interactions fall out of balance, the outcome can be deleterious for the healthy progress of other bodily functions. In some cases, an excess or lack of certain biomolecules can result in medical conditions. One such case is evident and problematic in patients that suffer from chronic wounds. This year, our team seeks a treatment to help restore balance to chronic wounds in hopes of reducing the healing time for patients.
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| − | </br></br></br><img src="https://static.igem.org/mediawiki/2016/c/cf/T--Lubbock_TTU--aristole.jpg" width="60%"></img>
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| − | </br></br><font size="4"><i>"All things in moderation" - Aristotle</i></font>
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| − | </br></br></br><img src="https://static.igem.org/mediawiki/2016/d/d0/T--Lubbock_TTU--mi200885f2.jpg" width="70%"></img>
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| − | </br></br><font size="6">The Art of Balance</font></br></br>
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| − | Biochemical pathways play a sophisticated balancing act within cells and the surrounding environment to maintain the proper emergent functionality of a biological system or process. For example, wound healing is generally categorized into four stages, hemostasis, inflammation, proliferation, and remodeling. These are emergent processes that occur in response to an injury and encompass a vast collection of interactions among proteins, cells, and biological mediators. The healthy progression of each stage can be characterized by a dependency on balanced physical and chemical interactions of these mediators and structural components. Our team has decided to focus on an enzyme which breaks down other molecules in a wound to allow new cells to migrate and grow. These enzymes are known as matrix metalloproteinases, and play a pivotal role in healthy wound healing. In chronic wounds, these proteins are present in surplus amounts and excessively degrade valuable bioactive molecules and structural proteins necessary for the wound to progress past the inflammation stage and begin healing again.
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| − | </br></br><font size="6" color="#5d5d5d">Restoring Balance with Synthetic Biology</font></br></br>
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| − | <font color="#5d5d5d">Experience has most likely reinforced the idea that balance is key to health, happiness, and well-being. There are lessons to be learned depending on how we apply an understanding of balance to the nature of the process in question. Regarding the human body, scientists have made significant progress in understanding the balance of interactions in biochemical and physiological systems ever since Robert Hooke discovered the first cell in 1665. The vast complexity of interactions in the body between the cells and tissues have made studying how these systems work difficult, yet rewarding. When these interactions fall out of balance, the outcome can be deleterious for the healthy progress of other bodily functions. In some cases, an excess or lack of certain biomolecules can result in medical conditions. One such case is evident and problematic in patients that suffer from chronic wounds. This year, our team seeks a treatment to help restore balance to chronic wounds in hopes of reducing the healing time.</font></br></br>
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| − | </br></br></br><img src="https://static.igem.org/mediawiki/2016/c/cf/T--Lubbock_TTU--aristole.jpg" width="45%"></img>
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| − | <!-- End of Section 4 -->
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