Difference between revisions of "Team:Lubbock TTU"

 
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                 <h1>Accelerated Wound Healing by Proteins-Infused BioBandage</h1>
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                 <h1>Enhanced Wound Healing Using a Protein-Infused Collagen Scaffold</h1>
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                 <h2>Texas Tech University</h2>
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                 <h2>Lubbock_TTU &middot; Texas Tech University</h2>
  
 
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            <h3 style="padding-top:100px;">Our Project</h3>
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A chronic wound is considered a wound that does not heal in an orderly set of stages or within a time period of about three months. The etiology of chronic wounds is very diverse. One of the most prevalent reasons patients have persistent chronic wounds is that their bodies produce too many proteases at the wound site. In turn, these proteases degrade the extracellular matrix of the wound site which acts as a scaffold for new cells to migrate and grow. Proteases have also been shown to decrease healing rates by degrading growth factors that are needed for recruiting wound healing cells and inducing cellular proliferation.
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</br></br>Wound healing progresses through three successive stages known as inflammation, proliferation, and remodeling. Ultimately, the degradation of the extracellular matrix and growth factor cause the wound to remain stuck in the inflammation phase, thus unable to heal.
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We will use synthetic biology principles to help treat chronic wounds by targeting the overproduction of wound site protease.
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<ul>
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</br><li>For Aim 1 we will genetically engineer E. coli to produce a protease inhibitor and platelet
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derived growth factor.
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<li>For Aim 2 we will purify the protease inhibitor and platelet derived growth factor in a
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bioreactor.
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<li>For Aim 3 we will design a collagen bandage that mimics the human extracellular matrix, and
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infuse it with purified protease inhibitor and platelet derived growth factor.
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</ul>
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</br>Our approach is two-fold. By infusing the collagen extracellular matrix with platelet derived
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growth factor and protease inhibitor, chronic wounds should be able to progress past the
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inflammation phase and begin healing once again.
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                 <h3>About Us</h3>
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                 <font color="#5d5d5d"><h3>About Us</h3></font>
 
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The Lubbock_TTU Team is part of a student organization at Texas Tech University known as iGEM Raiders. Our mission is to expose the university and community to synthetic biology through undergraduate initiative and involvement in the International Genetically Engineering Machine (iGEM) Competition.  
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<font color="#5d5d5d">The Lubbock_TTU Team is part of a student organization at Texas Tech University known as iGEM Raiders. Our mission is to expose the university and community to synthetic biology through undergraduate initiative and involvement in the International Genetically Engineering Machine (iGEM) Competition.  
  
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</br></br>This year, the iGEM Raiders team is composed of 12 dedicated undergraduate and graduate students with backgrounds in microbiology, animal science, cell and molecular biology, biochemistry, mathematics, physics, and chemical, mechanical, and electrical engineering. The diversity within our team enables the iGEM Raiders to tackle novel project ideas.
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</br></br>This year, the iGEM Raiders team is composed of 14 dedicated undergraduate and graduate students with backgrounds in microbiology, animal science, cell and molecular biology, biochemistry, mathematics, physics, and chemical, mechanical, and electrical engineering. The diversity within our team enables the iGEM Raiders to tackle novel project ideas.
 
                     <div id="readmore"><a href="https://2016.igem.org/Team:Lubbock_TTU/Team">Read more →</a></div><br></br>
 
                     <div id="readmore"><a href="https://2016.igem.org/Team:Lubbock_TTU/Team">Read more →</a></div><br></br>
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                 <a href="https://2016.igem.org/Team:Lubbock_TTU/Results">Project Results</a>
 
                 <a href="https://2016.igem.org/Team:Lubbock_TTU/Results">Project Results</a>
 
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Texas Tech University &middot; Lubbock, Texas
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Lubbock_TTU &middot; Texas Tech University
 
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Latest revision as of 16:45, 16 December 2016

About Us
The Lubbock_TTU Team is part of a student organization at Texas Tech University known as iGEM Raiders. Our mission is to expose the university and community to synthetic biology through undergraduate initiative and involvement in the International Genetically Engineering Machine (iGEM) Competition.

This year, the iGEM Raiders team is composed of 14 dedicated undergraduate and graduate students with backgrounds in microbiology, animal science, cell and molecular biology, biochemistry, mathematics, physics, and chemical, mechanical, and electrical engineering. The diversity within our team enables the iGEM Raiders to tackle novel project ideas.