Difference between revisions of "Team:Wageningen UR"

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(This is a preliminary project overview.)
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<h2> Welcome to iGEM 2016! </h2>
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<h2> Introduction </h2>
<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<p>Bees are the most important pollinators on earth and may account for a substantial proportion of the food we eat and therefore also for our quality of life [1, 2]. Their importance for the abundance and variety of our diet makes it all the more disturbing that honeybee mortality has been increasing in almost all western countries for at least 30 years [3, 4]. Sometimes even whole bee colonies die in one winter, a phenomenon that has been termed Colony Collapse Disorder (CCD). The most important cause of CCD is the parasitic mite Varroa destructor.  </p>
  
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<h2> Current treatments </h2>
  
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<p>In the Netherlands, the Varroa mite is now combatted by a year-round treatment with organic compounds that include Thymol, Formic acid and Oxalic acid. However, these compounds have to be applied strictly according to the provided instructions. Thymol, for instance, has a small concentration margin between killing the mites and harming bees. The hobbyist character of beekeeping has to be considered in the context of these treatments. Beekeepers might not have the time and resources to apply the treatments in the intended manner. </p>
<h5>Before you start: </h5>
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<p> Please read the following pages:</p>
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<ul>
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<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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<li> <a href="https://2016.igem.org/Resources/Template_Documentation"> Template Documentation </a></li>
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</ul>
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<h5> Wiki template information </h5>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
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<li>Have lots of fun! </li>
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</ul>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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</ul>
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<h5> Uploading pictures and files </h5>
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<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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UPLOAD FILES
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<h2>Synthetic Biological Treatment </h2>
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<p>We aim to create a new and better solution for the Varroa problem using synthetic biology. Our project would yield a product harmless to both humans and bees because we intend to use a Bacillus thuringiensis protein toxin to target Varroa. B. thuringiensis is known for the production of very specific insecticidal protein endotoxins. Multiple Bacillus strains have now been identified that target the Varroa mite. We will employ the toxins from these strains to relieve bee colonies from this most harmful parasite. In addition to the B. thuringiensis toxin, our synthetic biological system will contain systems to provide efficient production and release of the toxin and to provide users with a high level of control.  </p>
  
  
  
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<h2> References </h2>
  
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<li>
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<ol> 1. McGregor, Samuel Emmett. Insect pollination of cultivated crop plants. Vol. 496. Agricultural Research Service, US Department of Agriculture, 1976. </ol>
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<ol>
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2. Delaplane, Keith S. "On Einstein, Bees, and Survival of the Human Race." Entomology: UGA Honey Bee Program (2009). </ol>
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<ol>
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3. Potts, Simon G., et al. "Declines of managed honey bees and beekeepers in Europe." Journal of Apicultural Research 49.1 (2010): 15-22. </ol>
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<ol>
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4. Van der Zee, Romée, et al. "Managed honey bee colony losses in Canada, China, Europe, Israel and Turkey, for the winters of 2008–9 and 2009–10." Journal of Apicultural Research 51.1 (2012): 100-114. </ol>
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Revision as of 16:10, 27 June 2016

Introduction

Bees are the most important pollinators on earth and may account for a substantial proportion of the food we eat and therefore also for our quality of life [1, 2]. Their importance for the abundance and variety of our diet makes it all the more disturbing that honeybee mortality has been increasing in almost all western countries for at least 30 years [3, 4]. Sometimes even whole bee colonies die in one winter, a phenomenon that has been termed Colony Collapse Disorder (CCD). The most important cause of CCD is the parasitic mite Varroa destructor.

Current treatments

In the Netherlands, the Varroa mite is now combatted by a year-round treatment with organic compounds that include Thymol, Formic acid and Oxalic acid. However, these compounds have to be applied strictly according to the provided instructions. Thymol, for instance, has a small concentration margin between killing the mites and harming bees. The hobbyist character of beekeeping has to be considered in the context of these treatments. Beekeepers might not have the time and resources to apply the treatments in the intended manner.

Synthetic Biological Treatment

We aim to create a new and better solution for the Varroa problem using synthetic biology. Our project would yield a product harmless to both humans and bees because we intend to use a Bacillus thuringiensis protein toxin to target Varroa. B. thuringiensis is known for the production of very specific insecticidal protein endotoxins. Multiple Bacillus strains have now been identified that target the Varroa mite. We will employ the toxins from these strains to relieve bee colonies from this most harmful parasite. In addition to the B. thuringiensis toxin, our synthetic biological system will contain systems to provide efficient production and release of the toxin and to provide users with a high level of control.

References

    1. 1. McGregor, Samuel Emmett. Insect pollination of cultivated crop plants. Vol. 496. Agricultural Research Service, US Department of Agriculture, 1976.
      2. Delaplane, Keith S. "On Einstein, Bees, and Survival of the Human Race." Entomology: UGA Honey Bee Program (2009).
      3. Potts, Simon G., et al. "Declines of managed honey bees and beekeepers in Europe." Journal of Apicultural Research 49.1 (2010): 15-22.
      4. Van der Zee, Romée, et al. "Managed honey bee colony losses in Canada, China, Europe, Israel and Turkey, for the winters of 2008–9 and 2009–10." Journal of Apicultural Research 51.1 (2012): 100-114.