Difference between revisions of "Team:IISc Bangalore/Team"

 
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<head>
 
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<title>Team IISc iGem</title>
 
<title>Team IISc iGem</title>
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<meta name="viewport" content="width=device-width, initial-scale=1">
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<meta name="keywords" content="Team IISc igem" />
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<link href='//fonts.googleapis.com/css?family=Roboto:400,700' rel='stylesheet' type='text/css'>
 
<link href='//fonts.googleapis.com/css?family=Roboto:400,700' rel='stylesheet' type='text/css'>
 
<link href="https://fonts.googleapis.com/css?family=Bitter" rel="stylesheet">
 
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<link href="https://fonts.googleapis.com/css?family=Varela+Round" rel="stylesheet">
 
<link href="https://fonts.googleapis.com/css?family=Varela+Round" rel="stylesheet">
 
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  <a class="navbar-brand panel" onclick="openBar()" href="#" ><span class="glyphicon glyphicon-th
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"></span></a> </div>
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         <div class="collapse navbar-collapse" id="myNavbar">
 
         <div class="collapse navbar-collapse" id="myNavbar">
 
         <ul class="nav navbar-nav">
 
         <ul class="nav navbar-nav">
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           <li class="hvr-underline-from-left"><a href="#">Home</a></li>
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           <li class="active hvr-underline-from-left"><a href="https://2016.igem.org/Team:IISc_Bangalore">Home</a></li>
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           <li class="active hvr-underline-from-left"><a href="#">Team</a></li>
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           <li class="hvr-underline-from-left"><a href="https://2016.igem.org/Team:IISc_Bangalore/Team">Team</a></li>
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<li class="hvr-underline-from-left"><a href="#">Project</a></li>
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<li class="hvr-underline-from-left"><a href="#">Parts</a></li>
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        <li class="hvr-underline-from-left"><a href="#">Safety</a></li>
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<li class="dropdown"><a class="dropdown-toggle" data-toggle="dropdown" href="#">Project </a>
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        <li class="hvr-underline-from-left"><a href="#">Attributions</a></li>
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        <ul class="dropdown-menu">
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        <li class="hvr-underline-from-left"><a href="#">Practices</a></li>
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          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Description">Description</a></li>
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        <li class="hvr-underline-from-left"><a href="#">Awards</a></li>
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          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Experiments">Experiments</a></li>
 +
          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Results">Results</a></li>
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        </ul>
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      </li>
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<li class="hvr-underline-from-left"><a href="https://2016.igem.org/Team:IISc_Bangalore/Parts">Parts</a></li>
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                <li class="hvr-underline-from-left"><a href="https://2016.igem.org/Team:IISc_Bangalore/Collaborations">Collaborations</a></li>
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        <li class="hvr-underline-from-left"><a href="https://2016.igem.org/Team:IISc_Bangalore/Attributions">Attributions</a></li>
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        <li class="hvr-underline-from-left"><a href="https://2016.igem.org/Team:IISc_Bangalore/Human_Practices">Human Practices</a></li>
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        <li class="hvr-underline-from-left"><a href="https://2016.igem.org/Team:IISc_Bangalore/InterLab">InterLab</a></li>
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<li class="dropdown"><a class="dropdown-toggle" data-toggle="dropdown" href="#">Special Prizes</a>
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      <ul class="dropdown-menu">
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          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Integrated_Practices">Integrated Human Practices</a></li>
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          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Engagement">Education and Public Engagement</a></li>
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          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Model">Model</a></li>
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          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Measurement">Measurement</a></li>
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          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Entrepreneurship">Entrepreneurship</a></li>
 +
          <li><a href="https://2016.igem.org/Team:IISc_Bangalore/Design">Applied Design</a></li>
 +
        </ul>
 +
      </li>
 
         </ul>
 
         </ul>
  
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       </div>
 
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  <div class="banner-main">
 
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<span class="attri hvr-bounce-to-right ">The Team</span>
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<span class="attri hvr-bounce-to-right">The Team</html>
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[[File:IgemIISc.jpg|100px]]
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<html></span>
  
 
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<div class="welcome-grids">
 
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<h1>Leader</h1>
 
<div class="col-md-12 welcome-grid wow slideInDown animated" data-wow-delay=".5s" onclick="openPerson1()" id="overv">
 
<div class="col-md-12 welcome-grid wow slideInDown animated" data-wow-delay=".5s" onclick="openPerson1()" id="overv">
 
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<h4>Team Head</h4>
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<h4><i class="fa fa-male" aria-hidden="true"></i></h4>
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<p>A. C. ...</p>
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<p>Arunavo</p>
 
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<div class="row">
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<h1>Members</h1>
 +
<div class="col-md-4 person welcome-grid animated wow slideInLeft animated animated" data-wow-duration="1200ms" data-wow-delay="500ms" onclick="openPerson2()">
 
<div class="wel2 hvr-hang">
 
<div class="wel2 hvr-hang">
 
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<span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
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<h4>Member </h4>
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<h4><i class="fa fa-male" aria-hidden="true"></i></h4>
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<p>Member... </p>
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<p>Abhijeet</p>
 
</div>
 
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</div>
 
</div>
  
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<div class="col-md-4 welcome-grid wow slideInUp animated" data-wow-delay=".5s" onclick="openPerson3()">
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<h4>Member </h4>
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<h4><i class="fa fa-male" aria-hidden="true"></i></h4>
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<p>Member... </p>
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<p>Prabaha</p>
 
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<h4>Member </h4>
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<h4><i class="fa fa-male" aria-hidden="true"></i></h4>
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<p>Member... </p>
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<p>Shreyas</p>
 
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<h4>Member </h4>
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<h4><i class="fa fa-female" aria-hidden="true"></i></h4>
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<p>Member... </p>
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<p>Aiswarya</p>
 
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<div class="col-md-4 welcome-grid wow slideInUp animated" data-wow-delay=".5s" onclick="openPerson3()">
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<h4>Member </h4>
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<h4><i class="fa fa-male" aria-hidden="true"></i></h4>
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<p>Ayan</p>
 
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<h4>Member </h4>
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<h4><i class="fa fa-male" aria-hidden="true"></i></h4>
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<p>Member... </p>
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<p>Aneesh</p>
 
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<h4>Member </h4>
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<h4><i class="fa fa-female" aria-hidden="true"></i></h4>
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<p>Member... </p>
+
<p>Jessica</p>
 
</div>
 
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</div>  
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<div class="col-md-4 welcome-grid wow slideInRight animated" data-wow-delay=".5s" onclick="openPerson4()">
+
           
 +
            </div>  
  
 +
            <div class="row">
 +
<h1>Principal investigators</h1>         
 +
            <div class="col-md-6 person welcome-grid wow slideInRight animated" data-wow-delay=".5s" onclick="openPerson9()">
 +
          <div class="wel4 hvr-hang">
 +
            <span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
 +
              <h4>Asst. Prof. D. K. Saini</h4>
 +
           
 +
            </div>
 +
          </div>
 +
         
 +
<div class="col-md-6 person welcome-grid wow slideInRight animated" data-wow-delay=".5s" onclick="openPerson10()">
 
<div class="wel4 hvr-hang">
 
<div class="wel4 hvr-hang">
 
<span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
 
<span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
−
<h4>Member </h4>
+
<h4>Prof. Umesh Varshney</h4>
−
<p>Member... </p>
+
<p></p>  
 
</div>
 
</div>
 
</div>
 
</div>
 +
          </div>
 +
<div class="row">
 +
<h1>Instructors</h1>
 +
          <div class="col-md-6 person welcome-grid wow slideInRight animated" data-wow-delay=".5s" onclick="openPerson11()">
 +
        <div class="wel4 hvr-hang">
 +
          <span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
 +
            <h4>Dr. Srinath. T.</h4>
 +
          <p></p>
 +
          </div>
 +
        </div>
 +
       
 +
        <div class="col-md-6 person welcome-grid wow slideInRight animated" data-wow-delay=".5s" onclick="openPerson12()">
 +
        <div class="wel4 hvr-hang">
 +
          <span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
 +
          <h4>Dr. Narmada Khare</h4>
 +
          <p></p>
 +
          </div>
 +
        </div>
 +
       
 +
        </div>
 +
        <div class="row">
 +
  <h1>Mentors</h1>     
 +
        <div class="col-md-6 person welcome-grid wow slideInRight animated" data-wow-delay=".5s" onclick="openPerson13()">
 +
        <div class="wel4 hvr-hang">
 +
          <span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
 +
          <h4>Chaitra</h4>
 +
          <p>Mentor</p>
 +
          </div>
 +
        </div>
 +
     
 +
        <div class="col-md-6 person welcome-grid wow slideInRight animated" data-wow-delay=".5s" onclick="openPerson14()">
 +
      <div class="wel4 hvr-hang">
 +
        <span class="glyphicon glyphicon-chevron-down" aria-hidden="true" ></span>
 +
          <h4>Sachit</h4>
 +
        <p>Mentor</p>
 +
        </div>
 +
      </div>
 +
     
 +
     
 +
     
 +
      </div>
 
<div class="clearfix"></div>
 
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<div class="container" id="refer">
 
<div class="container" id="refer">
 
<div class="mid-content wow fadeInRight animated" data-wow-delay=".5s">
 
<div class="mid-content wow fadeInRight animated" data-wow-delay=".5s">
−
<h3>More about the team</h3>
+
<h3><i class="fa fa-chevron-circle-left" aria-hidden="true"></i> From the team</h3>
 
</div>
 
</div>
 
<div class="row">
 
<div class="row">
 
<div class="refer col-md-6">
 
<div class="refer col-md-6">
−
Other team aspects.
+
We are a group of undergraduate students from different fields with a common interest in biology.
 
</div>
 
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     <div class="col-md-6 person1Tabcontent">
 
     <div class="col-md-6 person1Tabcontent">
 
       <a href="javascript:void(0)" class="closebtn" onclick="closeTab()">&times;</a>
 
       <a href="javascript:void(0)" class="closebtn" onclick="closeTab()">&times;</a>
−
       <h1>Overview</h1>
+
       <h1>Arunavo Chakraborty</h1>  
−
       <p class="whitef">With the advent of rDNA technology in the late 1970s, medicine, agriculture and several other areas underwent a quantum leap and from that point, progress only hastened, from one only one recombinant pharmaceutical  approved for human use (insulin) in 1982 to one hundred and fifty-one FDA approved protein based recombinant pharmaceuticals by 2009<a href="#refer">[1]</a>.
+
</html>[[File:Arunavo3iisc.jpg|right|200px]]<html>
−
Despite being in high demand (due to the fact that most recombinant products produced on an industrial scale are therapies for chronic diseases like cancer and diabetes), recombinant products are expensive due to several factors like long and expensive development time, high failure rate (~80%) of the products developed, manufacturing costs requiring expensive technologies and processes (bioreactors, column chromatography, sterile conditions, etc) and the involvement of skilled labor on both the manufacturing and the healthcare provider’s side<a href="#refer">[2]</a>. Treatments with these pharmaceuticals can cost from around 10,000 to 100,000 € per year for a single patient[2]. As scientists and engineers, it seems obvious that our contribution can be most easily and effectively be made at the level of manufacturing costs; to try to bring down the cost of these life-saving products.
+
 
−
       <br><span class="readm hvr-ripple-out">Read more</span>
+
       <p class="whitef">Year: 3rd,
 +
Major: Chemistry; Minor: Biology<br>
 +
"I am a chemistry enthusiast with a recent inclination toward biology. What excites me the most about field is the incredible plethora of chemical reactions in biological systems that would (and do) give any chemist a run for their money. Currently, the topics that interest me are enzyme mechanics, peptide design and biomimetic chemistry. My (only) other companions are select manga and MMO (note, not RP) games."
 +
        
 
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    <div class="col-md-6 person2Tabcontent">
 
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      <a href="javascript:void(0)" class="closebtn" onclick="closeTab()">&times;</a>
−
      <h1>Bioreactor design</h1>
+
      <h1>Abhijeet Krishna</h1>
−
      <p class="whitef">We realized that manufacturing units use expensive and energy expensive machinery <a href="#refer">[3]</a>. Hence, we engineered our bacteria in such a way that it could do most of the work done by these monstrous machines so that we no longer have to buy them and pay their bills.
+
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To increase the yield of the product, we came up with the idea of separating cell growth and target protein production so that when the cells have grown up to a high enough cell density, they shuttle all their energy towards the required protein production<a href="#refer"> [4]</a>. Based on the above ideas, we came up with the design of our bioreactor.
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<p>We realized that we would not be able to work on the whole idea this summer so, we focussed on two modules of our design: the Protein production module and the auto-aggregation module leaving the arresting of cell growth for future iGEM teams as a seed for their ideas.
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      <p class="whitef">Year: 3rd,  
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Major:Physics<br>
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"Hello! I have always believed that simple scientific ideas can influence society greatly and that is exactly what I am trying to show in iGEM. I am married to Physics and have an affair with Biology. I am a Calvin and Hobbes fan and can’t resist kebabs."
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      <h1>Prabaha Gangopadhyay</h1>
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      <p class="whitef">Induction synthesis of protein of interest is another important step. Microorganisms in bioreactors are induced at the OD, at which the protein production is maximum. <a href="#refer">[5]</a> Because of this, factories install sophisticated machinery to keep track of the OD value of the culture so as to know when to induce the production. We wanted our bacteria to know when to start protein production and start it by itself. Hence, we used the lux quorum sensing system to sense this cell density. <a href="#refer">[6]</a> We have expressed the gene for our protein of interest under the luxI gene so that protein of interest is produced in significant quantities only when the quorum is achieved.(Figure 2) We also wish to tune the quorum sensing system by tweaking with the strength of the promoters involved in quorum sensing.
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      <p class="whitef">Year: 3rd,
 +
Major: Biology<br>
 +
"I like learning about mechanisms underlying the existence of life. I find myself comfortable in the overlap of theoretical and experimental biology, because of the extreme interdisciplinary nature of the area, and being at IISc has allowed me to explore it. I am interested in doing my final year project, and eventually my PhD, in Neuroscience. Other than science, I love literature, classical music, and, like any other undergrad, food!"
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      <h1>Auto-aggregation</h1>
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      <h1>Shreyas Gopalakrishnan</h1>
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      <p class="whitef">To achieve cellular aggregation, we use the famous auto-transporter protein, Antigen43 (Ag43). [7] It has shown to cause auto-aggregation of cells when overexpressed. (Figure 3) We plan to exploit this property of Ag43 to substitute centrifugation. We acknowledge previous iGEM teams who have worked on Ag43 (Hokkaido University, 2012; Aberdeen Scotland, 2014 and some more) as we got the BioBricks for Ag43 readily available. We intend to express Ag43 only when the cells have made the product of interest. Hence, we use the diauxic shift in the media to act as a switch for the expression of Ag43.
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      <p class="whitef">Year: 3rd,  
 +
Major: Biology; Minor: Physics<br>
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"I am interested in the problems in biology, but using a variety of physical and other methods/approaches to show consistent, robust and reproducible results. Recently, I also became interested in designing experiments, especially in stem cell biology and cell imaging. I'd like to learn general principles from diverse areas of science so that I can apply them in biology. In my free time, I listen to generic pop music."
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      <h1>Aiswarya Prasad</h1>
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      <p class="whitef">Year: 2nd,
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Major:Undecided (Biology, eventually)<br>
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"I have always been most fascinated by how life works, by virtue of nothing more than 'molecules'. I enjoy learning and thinking about most things that even remotely belong in the realm of science. I wish to pursue whatever it is that intrigues me most, wherever that takes me. I also enjoy reading, classical music and occasionally gaming."
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      <h1>Ayan Das</h1>
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      <p class="whitef">Year: 2nd,
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Major: Unassigned. (Most likely Biology) <br>
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"I am mostly interested in biology but with a strong inclination towards maths and computation. Papers that don't have equations bore the life out of me! I easily get interested in just about anything. I have no concrete plans for the future. At the moment, I'm just enjoying everything that I am getting to learn. Apart from science, I like writing and playing the keyboard (which I have just started learning). Hopefully, I'll contribute something significant to the scientific community some day." 
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      <h1>Aneesh Baburaj</h1>
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      <p class="whitef">Year: 2nd,
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Major:Unassigned. <br>
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"I believe that every living being is a complex machine which needs to be understood and synthetic biology permits that by mimicing events and organisms. And that's why I find biology very intriguing."
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      <h1>Jessica</h1>
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      <p class="whitef">Year: 2nd,
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Major: Most likely biology. <br>
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"I am interested in biology and chemistry, many people tell me that everything in the world is maths rest are all applications of it but these very applications are so amazing and complex that people are amazed how organisms have evolved to be so smart."
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                      <h1>Asst. Prof. Deepak K. Saini</h1>
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                      <p class="whitef"> Assistant Professor at Department of Molecular Reproduction, Development and Genetics also Associate Faculty (Biosystems Science and Engineering) Indian Institute of Science.
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                                      <h1>Prof. Umesh Varshney</h1>
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                                      <p class="whitef"> Professor at the Microbiology and Cell Biology Department, Indian Institute of Science.
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                                                      <h1>Dr. Srinath Thiruneelkantan</h1>
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                                                      <p class="whitef">U.G. biology instructor IISc. He was very helpful in brainstorming sessions and in troubleshooting. 
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                                                                      <h1>Dr. Narmada Khare</h1>
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U.G. biology instructor IISc. She was very helpful in brainstorming sessions and in troubleshooting.                                                                </p>
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                                                                                                  <h1>Chaitra Prabhakar</h1>
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Ph. D. student in NCBS, Bangalore, India. The team received help during its brainstorming sessions.                                                                                                </p>
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                                                                                                                  <h1>Sachit Daniel</h1>
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Latest revision as of 16:46, 19 October 2016



Team IISc iGem

Leader

Arunavo

Members

Abhijeet

Prabaha

Shreyas

Aiswarya

Ayan

Aneesh

Jessica

Principal investigators

Asst. Prof. D. K. Saini

Prof. Umesh Varshney

Instructors

Dr. Srinath. T.

Dr. Narmada Khare

Mentors

Chaitra

Mentor

Sachit

Mentor

From the team

We are a group of undergraduate students from different fields with a common interest in biology.
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Arunavo Chakraborty

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Year: 3rd, Major: Chemistry; Minor: Biology
"I am a chemistry enthusiast with a recent inclination toward biology. What excites me the most about field is the incredible plethora of chemical reactions in biological systems that would (and do) give any chemist a run for their money. Currently, the topics that interest me are enzyme mechanics, peptide design and biomimetic chemistry. My (only) other companions are select manga and MMO (note, not RP) games."

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Abhijeet Krishna

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Year: 3rd, Major:Physics
"Hello! I have always believed that simple scientific ideas can influence society greatly and that is exactly what I am trying to show in iGEM. I am married to Physics and have an affair with Biology. I am a Calvin and Hobbes fan and can’t resist kebabs."

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Prabaha Gangopadhyay

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Year: 3rd, Major: Biology
"I like learning about mechanisms underlying the existence of life. I find myself comfortable in the overlap of theoretical and experimental biology, because of the extreme interdisciplinary nature of the area, and being at IISc has allowed me to explore it. I am interested in doing my final year project, and eventually my PhD, in Neuroscience. Other than science, I love literature, classical music, and, like any other undergrad, food!"

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Shreyas Gopalakrishnan

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Year: 3rd, Major: Biology; Minor: Physics
"I am interested in the problems in biology, but using a variety of physical and other methods/approaches to show consistent, robust and reproducible results. Recently, I also became interested in designing experiments, especially in stem cell biology and cell imaging. I'd like to learn general principles from diverse areas of science so that I can apply them in biology. In my free time, I listen to generic pop music."

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Aiswarya Prasad

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Year: 2nd, Major:Undecided (Biology, eventually)
"I have always been most fascinated by how life works, by virtue of nothing more than 'molecules'. I enjoy learning and thinking about most things that even remotely belong in the realm of science. I wish to pursue whatever it is that intrigues me most, wherever that takes me. I also enjoy reading, classical music and occasionally gaming."

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Ayan Das

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Year: 2nd, Major: Unassigned. (Most likely Biology)
"I am mostly interested in biology but with a strong inclination towards maths and computation. Papers that don't have equations bore the life out of me! I easily get interested in just about anything. I have no concrete plans for the future. At the moment, I'm just enjoying everything that I am getting to learn. Apart from science, I like writing and playing the keyboard (which I have just started learning). Hopefully, I'll contribute something significant to the scientific community some day."

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Aneesh Baburaj

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Year: 2nd, Major:Unassigned.
"I believe that every living being is a complex machine which needs to be understood and synthetic biology permits that by mimicing events and organisms. And that's why I find biology very intriguing."

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Jessica

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Year: 2nd, Major: Most likely biology.
"I am interested in biology and chemistry, many people tell me that everything in the world is maths rest are all applications of it but these very applications are so amazing and complex that people are amazed how organisms have evolved to be so smart."

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Asst. Prof. Deepak K. Saini

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Assistant Professor at Department of Molecular Reproduction, Development and Genetics also Associate Faculty (Biosystems Science and Engineering) Indian Institute of Science.

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Prof. Umesh Varshney

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Professor at the Microbiology and Cell Biology Department, Indian Institute of Science.

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Dr. Srinath Thiruneelkantan

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U.G. biology instructor IISc. He was very helpful in brainstorming sessions and in troubleshooting.

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Dr. Narmada Khare

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U.G. biology instructor IISc. She was very helpful in brainstorming sessions and in troubleshooting.

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Chaitra Prabhakar

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Ph. D. student in NCBS, Bangalore, India. The team received help during its brainstorming sessions.

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Sachit Daniel

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Ph. D. student in NCBS, Bangalore, India. Helped the team in its brainstorming sessions.

Sponsors



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