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<p><div id="Project_Description"><img src="https://static.igem.org/mediawiki/2016/d/d2/T--HokkaidoU_Japan--project_description.png" | <p><div id="Project_Description"><img src="https://static.igem.org/mediawiki/2016/d/d2/T--HokkaidoU_Japan--project_description.png" | ||
width="300px" height="110px" alt="Project description"></div></p> | width="300px" height="110px" alt="Project description"></div></p> | ||
− | + | <br>We considered possible application of self-assembling peptides (SAPs). SAPs have a self-assembling ability because they are amphiphilic peptides and contain hydrophobic and hydrophilic residues. These electric charged amino acids interact with one another to form spontaneously antiparallel β-sheet in a physiochemical environmental condition. </br> | |
− | + | <br>We use one of SAP, RADA-16-(RADARADARADARADA)and P11-4 (QQRFEWEFEQQ). RADA-16-I has been established for 3-D culture of neural stem cells (NSCs) by creating nanostructures. P11-4 has been designed to form fibers at low pH and have a cytocompatibility. </br> | |
− | + | <br>Recently, SAPs have been used for a nanostructured hydrogel. We considered new application methods of SAPs such as enhancement of enzymatic activity. For example, circulated enzymes offer a potential to stablize with heat and pH and multimeric one may be continuously reactive. </br> | |
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<p><div id="Background"><img src="https://static.igem.org/mediawiki/2016/1/1c/T--HokkaidoU_Japan--background.png" | <p><div id="Background"><img src="https://static.igem.org/mediawiki/2016/1/1c/T--HokkaidoU_Japan--background.png" |
Revision as of 02:12, 15 October 2016
Team:HokkaidoU Japan
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We considered possible application of self-assembling peptides (SAPs). SAPs have a self-assembling ability because they are amphiphilic peptides and contain hydrophobic and hydrophilic residues. These electric charged amino acids interact with one another to form spontaneously antiparallel β-sheet in a physiochemical environmental condition.
We use one of SAP, RADA-16-(RADARADARADARADA)and P11-4 (QQRFEWEFEQQ). RADA-16-I has been established for 3-D culture of neural stem cells (NSCs) by creating nanostructures. P11-4 has been designed to form fibers at low pH and have a cytocompatibility.
Recently, SAPs have been used for a nanostructured hydrogel. We considered new application methods of SAPs such as enhancement of enzymatic activity. For example, circulated enzymes offer a potential to stablize with heat and pH and multimeric one may be continuously reactive.
ここに本文
ここに本文
![Project description](https://static.igem.org/mediawiki/2016/d/d2/T--HokkaidoU_Japan--project_description.png)
We considered possible application of self-assembling peptides (SAPs). SAPs have a self-assembling ability because they are amphiphilic peptides and contain hydrophobic and hydrophilic residues. These electric charged amino acids interact with one another to form spontaneously antiparallel β-sheet in a physiochemical environmental condition.
We use one of SAP, RADA-16-(RADARADARADARADA)and P11-4 (QQRFEWEFEQQ). RADA-16-I has been established for 3-D culture of neural stem cells (NSCs) by creating nanostructures. P11-4 has been designed to form fibers at low pH and have a cytocompatibility.
Recently, SAPs have been used for a nanostructured hydrogel. We considered new application methods of SAPs such as enhancement of enzymatic activity. For example, circulated enzymes offer a potential to stablize with heat and pH and multimeric one may be continuously reactive.
![background](https://static.igem.org/mediawiki/2016/1/1c/T--HokkaidoU_Japan--background.png)
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![achievements](https://static.igem.org/mediawiki/2016/9/99/T--HokkaidoU_Japan--achievements.png)
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