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<h1><b>Quorum Sensing</b></h1>
 
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<p><b> What is quorum sensing</b><br>
 
<p><b> What is quorum sensing</b><br>
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Quorum sensing is a cell-cell communication system. The detection of chemical molecules allows the bacteria to distinguish between low and high cell densities, in this way control gene expression in response to changes in cell number <sup> <a href="#fn1" id="ref1">1</a></sup>. 
 
<p> <b>Methods</b> <br>
 
<p> <b>Methods</b> <br>
 
During the research Matlab version R2016a has been used. <br>
 
During the research Matlab version R2016a has been used. <br>
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<h2>References</h2>
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<a id="fn1" href=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485958/>1.</a> Eri Nasuno, Nobutada Kimura, Masaki J. Fujita, Cindy H. Nakatsu, Yoichi Kamagata, and  Satoshi Hanada (2012). Phylogenetically Novel LuxI/LuxR-Type Quorum Sensing Systems Isolated Using a Metagenomic Approach
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Vol, 78, number 22. <a href="#ref1" title="Jump back to footnote 1 in the text.">↩</a>
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Revision as of 16:00, 5 October 2016

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Wageningen UR iGEM 2016

 

Overview

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Quorum Sensing

What is quorum sensing
Quorum sensing is a cell-cell communication system. The detection of chemical molecules allows the bacteria to distinguish between low and high cell densities, in this way control gene expression in response to changes in cell number 1.

Methods
During the research Matlab version R2016a has been used.
Because there was no data from the wet lab we assumed that all the parameters in the system were random. The parameters are all obtained by latin hypercube Latin hypercube is a statistical method to get random numbers from a box of n by n numbers. For example x = 4 with x is divisions and n = 2 with n is number of samples. You will obtain a box with 4 square times 2 square, give you 24 random numbers. For each parameter one number out of this box is randomly chosen. samples.

How could quorum sensing develop spatial inhomogeneities in toxin/anti-toxin systems?
When quorum sensing ensures that the toxin is only produced when the density of bacteria is high enough to produce significant amounts of toxin, this ‘standardizes’ the amount of toxin produced by the bacteria. The toxin/anti-toxin system will be coupled to the quorum sensing system. Together, quorum sensing and forming of non-producing subpopulations by the toxin/anti-toxin system, allow bacteria to produce ‘waves’ of toxin.

Results

Quorum sensing system

References

    1. Eri Nasuno, Nobutada Kimura, Masaki J. Fujita, Cindy H. Nakatsu, Yoichi Kamagata, and Satoshi Hanada (2012). Phylogenetically Novel LuxI/LuxR-Type Quorum Sensing Systems Isolated Using a Metagenomic Approach Vol, 78, number 22. ↩