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<h1 style="text-align:center; font-size: 50px;"><font face= "Poiret One">Introduction</h2><br> | <h1 style="text-align:center; font-size: 50px;"><font face= "Poiret One">Introduction</h2><br> | ||
− | <p style="text-align:center; font-size:20px;"><font face="verdana">Mathematical models greatly aid in the prediction of the outcome of a biological design. Our mathematical model will be employed to test the efficacy of an aptamer based proximity-dependent ligation assay (PLA) in the detection of biomarkers. The proximity dependent ligation assay is an extension to the traditional immunoassay and can be used for protein detection with high specificity and sensitivity. The selectivity of the proximity dependent ligation assay is dramatically enhanced through the double recognition by two oligonucleotide-conjugated aptamers. We sought to optimize the aptamer-protein equilibria to promote the efficient and precise binding of the aptamer with the target molecule.</font><br | + | <p style="text-align:center; font-size:20px;"><font face="verdana">Mathematical models greatly aid in the prediction of the outcome of a biological design. Our mathematical model will be employed to test the efficacy of an aptamer based proximity-dependent ligation assay (PLA) in the detection of biomarkers. The proximity dependent ligation assay is an extension to the traditional immunoassay and can be used for protein detection with high specificity and sensitivity. The selectivity of the proximity dependent ligation assay is dramatically enhanced through the double recognition by two oligonucleotide-conjugated aptamers. We sought to optimize the aptamer-protein equilibria to promote the efficient and precise binding of the aptamer with the target molecule.</font><br></p> |
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Revision as of 21:55, 18 October 2016