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<div class="sec white"> | <div class="sec white"> | ||
<div id="freiburg"> <h2>FREIBURG</h2> | <div id="freiburg"> <h2>FREIBURG</h2> | ||
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+ | <div class="image_box" style="max-width: 500px;"> | ||
+ | <a href="https://2016.igem.org/File:T--ETH_Zurich--killSwitch.png"> | ||
+ | <img src="https://static.igem.org/mediawiki/2016/a/a4/T--ETH_Zurich--killSwitch.png"> | ||
+ | </a> | ||
+ | <p><b>Figure 1:</b> kill-switch overview</p> | ||
+ | </div> | ||
<div> | <div> | ||
<p>We have been in contact with the Freiburg team since the beginning of the iGem adventure. We quickly realized that our respective project were going in the same direction, as we were both focusing on <i>Colitis ulcerosa</i> and engineering bacteria to fight diseases in vivo. However unlike us Freiburg is focusing on finding a way to facilitates local activation of targetted drug-delivery, and uses spores of <i>Bacillus subtilis</i>. | <p>We have been in contact with the Freiburg team since the beginning of the iGem adventure. We quickly realized that our respective project were going in the same direction, as we were both focusing on <i>Colitis ulcerosa</i> and engineering bacteria to fight diseases in vivo. However unlike us Freiburg is focusing on finding a way to facilitates local activation of targetted drug-delivery, and uses spores of <i>Bacillus subtilis</i>. |
Revision as of 11:37, 16 October 2016
COLLABORATION
FREIBURG
We have been in contact with the Freiburg team since the beginning of the iGem adventure. We quickly realized that our respective project were going in the same direction, as we were both focusing on Colitis ulcerosa and engineering bacteria to fight diseases in vivo. However unlike us Freiburg is focusing on finding a way to facilitates local activation of targetted drug-delivery, and uses spores of Bacillus subtilis.
MazF is a toxin while MazE is the anti-toxin. The MazEF complex also inhibits the Pmaz promoter. The idea of the switch is to synthesize under certain conditions the anti-MazE protein which prevents translation of the MazE protein. Thus it will prevent it from binding MazF. The concentration of MazF in the circuit will increase and lead to cell death.
For More information on their amazing project, please click on the link below:
UI INDONESIA
We had a skype meeting with UI Indonesia and gave them an introduction to parameter estimation approaches.