Difference between revisions of "Team:Bordeaux"

 
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    <section id="banner">        
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<h2> Welcome to iGEM 2016! </h2>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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        <div class="banner"></div>
  
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<h5>Before you start: </h5>
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<p> Please read the following pages:</p>
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<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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<li> <a href="https://2016.igem.org/Resources/Template_Documentation"> Template Documentation </a></li>
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<h5> Wiki template information </h5>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<li class="icon"> <a class="hu-icon"><img id="Sstart" src="https://static.igem.org/mediawiki/2016/6/6b/T--Bordeaux--Button2.png" style="width:130px; height:auto;" alt="Story Button"/>The story</a></li>
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<li class="icon"> <a class="hu-icon"><img id="Astart" src="https://static.igem.org/mediawiki/2016/f/f3/T--Bordeaux--Button.png" style="width:130px; height:auto;" alt="Abstract Button"/>Abstract</a></li> 
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<li class="icon"> <a class="hu-icon"><img id="Tstart" src="https://static.igem.org/mediawiki/2016/0/03/T--Bordeaux--FooGIF.gif" style="width:130px; height:auto;" alt="Team Button"/>Our team</a></li>        
  
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
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<li>Have lots of fun! </li>
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  <h1 id="comic" >Sleepy's Adventures</h1>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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  <img src="https://static.igem.org/mediawiki/2016/9/9a/T--Bordeaux--SleepyAdventures.png" style="display:block;margin-left:auto;margin-right:auto; width:80%;height:auto" title="Sleepy's Adventures">
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<h5> Uploading pictures and files </h5>
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  </div>
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<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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UPLOAD FILES
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        <h1 id="abstract">Who has never suffered from sleep disorders ?</h1>
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        <h3 align="justify">Background</h3>
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            <p align="justify">A 2008 report by the INPES, a French public institute, has shown that 45% of the 25-45 year-old population considers that they <b>do not sleep enough</b>. This lack of sleep causes a fair bit of <b>negative impacts</b> : decrease of focus, weakened immune system, cardiovascular disease risk increase ... Even if these statistics are high, today's medical knowledge is not sufficient enough when it comes to healing people who suffer from <b>sleep disorders</b>. A classic example would be sleeping pills for chronic insomnia. However, they only treat the symptoms, not the source. This drew our attention, enough to provoke unanimity for this project within our team.</p>
 +
 +
        </div>
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 +
        <div class="column half_size">
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 +
<h3 align="justify">Objectives</h3>
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            <p align="justify">This year, iGEM Bordeaux aims to study <b>DSIP</b>, a sleep-inducing peptide which seems to be promising for the given dilemma. In order to understand in which mechanisms this peptide is involved, it will be introduced in  the nematode <b><i>Caenorhabditis elegans</i></b> to see the effects on its sleep. Another aspect is to <b>control the nematode's sleep pattern</b>. On the one hand, we want to make a <b>photo-inducible system</b> that can be used on sleep gene promoters. On the other hand, we aim to create a new tool to modify the sleep genes using epigenetics: <b>EpiCRISPR</b>. Based on the CRISPR-CAS9 concept, we want to design it according to many strategies, see more details in the <a href="https://2016.igem.org/Team:Bordeaux/Description">Description</a> part.</p>
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            <h4 align="center">Our final goal is to compare the two approaches - the photo-inductible system and the EpiCRISPR system - and see which one would be easy to handle for the <i> C.elegans</i>'s sleep control.</h4>
 +
 
 +
            <h3>Safety Considerations</h3>
 +
 
 +
            <p align="justify">Our team has also taken interest in the issue of <b>security and safety</b> in synthetic biology. This field requires the creation of many modified organisms, and their proliferation has to be taken into account and totally under control. The <b>Good Laboratory Practices</b> help researchers to garantee security and protection in the laboratory, and prevent the dissemination of modified organisms.<br>
 +
            However, no one is safe from being distracted and committing an error. In these cases, one can wonder how to evaluate the growth of a modified organism in the environment. To answer this question, our team wishes to conceive a <b>computational model</b> to measure the growth and behaviour of bacterial colonies in a given environment. This model aims to analyze if the colonies are likely to survive and determine the percentage of plasmids in the bacterial population.</p>
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    <section id="team_intro">
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                <h1>An original project from iGEM Bordeaux</h1>
 +
 
 +
                <p style="font-size:1.5em;
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                    text-align:center;" >We are 21 students from Bordeaux University and the engineering school ENSTBB. <br> Click <a href="https://2016.igem.org/Team:Bordeaux/Team">here</a> for more informations about us ! </p>
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            </div>
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        </div>
  
 
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        <video controls src="https://static.igem.org/mediawiki/2016/1/18/Logo_animation_from_Toulouse.webm" style="width:700px;height:auto" autoplay="true">iGEM Bordeaux</video>
  
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    <section id="sponsors">
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                <h1>Our sponsors</h1>
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                <p style="font-size:1.5em; text-align:center;" >We would like to thank our sponsors for allowing us to build this project and present it at the 2016 iGEM competition in Boston!</p>
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{{Bordeaux/Footer}}

Latest revision as of 01:10, 20 October 2016

Sleep with EpiC elegans

Sleepy's Adventures

Who has never suffered from sleep disorders ?

Background

A 2008 report by the INPES, a French public institute, has shown that 45% of the 25-45 year-old population considers that they do not sleep enough. This lack of sleep causes a fair bit of negative impacts : decrease of focus, weakened immune system, cardiovascular disease risk increase ... Even if these statistics are high, today's medical knowledge is not sufficient enough when it comes to healing people who suffer from sleep disorders. A classic example would be sleeping pills for chronic insomnia. However, they only treat the symptoms, not the source. This drew our attention, enough to provoke unanimity for this project within our team.

Objectives

This year, iGEM Bordeaux aims to study DSIP, a sleep-inducing peptide which seems to be promising for the given dilemma. In order to understand in which mechanisms this peptide is involved, it will be introduced in the nematode Caenorhabditis elegans to see the effects on its sleep. Another aspect is to control the nematode's sleep pattern. On the one hand, we want to make a photo-inducible system that can be used on sleep gene promoters. On the other hand, we aim to create a new tool to modify the sleep genes using epigenetics: EpiCRISPR. Based on the CRISPR-CAS9 concept, we want to design it according to many strategies, see more details in the Description part.

Our final goal is to compare the two approaches - the photo-inductible system and the EpiCRISPR system - and see which one would be easy to handle for the C.elegans's sleep control.

Safety Considerations

Our team has also taken interest in the issue of security and safety in synthetic biology. This field requires the creation of many modified organisms, and their proliferation has to be taken into account and totally under control. The Good Laboratory Practices help researchers to garantee security and protection in the laboratory, and prevent the dissemination of modified organisms.
However, no one is safe from being distracted and committing an error. In these cases, one can wonder how to evaluate the growth of a modified organism in the environment. To answer this question, our team wishes to conceive a computational model to measure the growth and behaviour of bacterial colonies in a given environment. This model aims to analyze if the colonies are likely to survive and determine the percentage of plasmids in the bacterial population.

An original project from iGEM Bordeaux

We are 21 students from Bordeaux University and the engineering school ENSTBB.
Click here for more informations about us !


Our sponsors

We would like to thank our sponsors for allowing us to build this project and present it at the 2016 iGEM competition in Boston!

How to find us ?

Feel free to email us to provide some feedback on our project, have some information on the team and our work, or to just say hello !

Mail: igembdx@gmail.com
Copyright © iGEM Bordeaux 2016