Difference between revisions of "Team:SUSTech Shenzhen"

 
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                    <a href="https://2016.igem.org/Team:SUSTech_Shenzhen/Description" class="btn btn-primary btn-xl">EXPLORE  <i class="ion-arrow-right-c">
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                <h2 class="margin-top-0 text-primary">Discovering the Secret of Sound</h2>
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                    <p>We use synthetic biology methods to explore how cells sense mechanical stress, such as sound wave. Traditional gene expression regulation techniques, for example, optogenetics and chemical genetics, are commonly used in biological science but with certain limitations. Here we design a new way, audiogenetics, by which we can not only regulate gene expression in cells precisely and nontoxically, but also have an in-depth and comprehensive understanding of our feelings.</p>
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Recently, gene express regulation techniques such as optogenetics and chemical genetics are commonly used in biology science, however, they all have their own limitation of drawbacks. Here we design a new way, audiogenetics, to precisely and nontoxicly regulate the gene expression in cells. It used a membrane mechanosensitive channel transient receptor potential channel 5 (TRPC5) and mammalian mechanosensitive Piezo1 channel to transform the audio wave energy as the input signal from extracellular into intracellular downstream signal. To make the TRPC5 more sensitive to mechanical stress, we use protein engineering by evolution to get a mutated TRPC5 with a high sensitive to sound waves. The downstream signal is calcium ion, which is the second messenger in cells and we use calcium indicator (R-GECO) to quantify the intracellular calcium by using live cell image. Calcium in cytosolic can regulate a series of phosphorylation and we know that it can induce the specific promoters (PNFAT) transgene expression. Finally, we use the GFP as the output signal to quantitatively analysis the regulatory ability of audiogenetics.
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                <a href="#three" class="btn btn-default btn-xl page-scroll">Projects</a>
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                <h2 class="margin-top-0 text-primary">In a Glance</h2>
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                    <h3>One Target</h3>
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                    <p class="text-muted">to make the world audible again</p>
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                    <h3>Two Channels</h3>
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                    <p class="text-muted">quantified to the core</p>
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                    <h3>Three Systems</h3>
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                    <p class="text-muted">made by scientists for scientists</p>
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Latest revision as of 02:56, 20 October 2016

Team SUSTC-Shenzhen

GLANCE
EXPLORE

In a Glance

One Target

to make the world audible again

Two Channels

quantified to the core

Three Systems

made by scientists for scientists

EXPLORE

Made by from the iGEM team SUSTech_Shenzhen.

Licensed under CC BY 4.0.

  • ©2016 SUSTech_Shenzhen