Difference between revisions of "Team:Lethbridge HS/Description"

 
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−
{{Lethbridge_HS}}
+
{{Team:Lethbridge_HS/bootstrapcss}}  
−
<html>
+
<html lang="en">
 +
    <head>
 +
       
 +
       
 +
       
 +
        <!-- Wiki Style Reset (From U of C)-->
 +
    <style type="text/css">
 +
      /* Reset the wiki style by overriding with a reset stylesheet.
 +
        The relevant wiki css rules are reset by using rules with higher priority.
 +
        (Written by Florian Albrecht)
 +
        Shoutout to the 2016 U of C wiki */
  
 +
      /* Start general reset ================================================== */
 +
        html body {font-size: inherit;font-family: inherit;background-color: transparent;color: inherit;padding: 0;}
 +
        div#globalWrapper {font-size: inherit;margin: 0;padding: 0;position: static;width: auto;}
 +
      /* Start top-section reset ============================================== */
 +
        div#top-section {border: 0;height: auto;margin: 0;position: static;width: auto;}
 +
        div#p-logo {height: auto;position: static;width: auto;z-index: auto;}
 +
        div#p-logo a, div#p-logo a:hover {text-decoration: none; font-family: 'Roboto', sans-serif;}
 +
        div#menubar {font-family: inherit;font-size: inherit;line-height: inherit;position: static;top: 0px;white-space: normal;width: auto;z-index: auto;}
 +
        div.left-menu, div.left-menu a {color: inherit;left: 0;text-align: left;text-transform: none;font-family: 'Roboto', sans-serif;}
 +
        div#menubar ul {color: inherit;list-style: disc outside none;margin: 0;padding: 0; font-family: 'Roboto', sans-serif;}
 +
        div#menubar li {cursor: auto;display: list-item;padding: 0;margin: 0;position: static; font-family: 'Roboto', sans-serif;}
 +
        div.left-menu li a {padding: 0; font-family: 'Roboto', sans-serif;}
 +
        div.left-menu:hover {color: inherit;background-color: transparent;}
 +
        div.left-menu:hover a {color: inherit;font-family: 'Roboto', sans-serif;}
 +
        div.right-menu, div.right-menu a {color: inherit;right: 0;text-align: left;font-family: 'Roboto', sans-serif;}
 +
        div.right-menu li a {background-color: transparent;color: inherit;padding: 0;font-family: 'Roboto', sans-serif;}
 +
        div.right-menu li a:hover {color: inherit;text-decoration: none;font-family: 'Roboto', sans-serif;}
 +
        div#search-controls {background-color: transparent;height: auto;position: static;right: 0;text-align: left;top: 0;width: auto;z-index: auto;}
 +
      /* Start content reset ================================================== */
 +
        div#content {background: transparent;border: 0;color: inherit;line-height: inherit;margin: 0;padding: 0;position: static;width: auto;z-index: auto;}
 +
        body li {margin: 0; font-family: 'Roboto', sans-serif;}
 +
        body h1, body h2, body h3, body h4, body h5, body h6 {background: transparent;border: 0;color: inherit;padding: 0; font-family: 'Roboto', sans-serif;}
 +
        body .firstHeading {margin: 0;}
 +
        div#contentSub {color: inherit;font-size: inherit;line-height: inherit;margin: 0;width: auto;}
 +
        div#catlinks {background-color: transparent;border: 0;clear: both;margin: 0;padding: 0;}
 +
      /* Start footer reset =================================================== */
 +
        div#footer-box {background-color: transparent;border: 0;margin: 0;padding: 0;width: auto;}
 +
        div#footer {color: inherit;font-size: inherit;text-align: left;}
 +
        div#f-poweredbyico, div#f-copyrightico {float: none;}
 +
        div#footer li {margin: 0;display: list-item; font-family: 'Roboto', sans-serif;}
 +
      </style>
  
 +
      <!-- SideMenu for iGEM Stuff -->
 +
      <style type="text/css">
 +
      #sideMenu{width: 200px;position: absolute;top: 20px;left: 1020px;z-index: 10;padding-top: 0px;padding-bottom: 15px;padding-left: 15px;padding-right: 15px;background-color: white;text-align: left;display: none;z-index: 9996;}
 +
      #content{width: 100%;padding: 0px;margin-left: 0px;}
 +
      #top_title{overflow: hidden;display: none;}
 +
      #top_menu_14{height: 20px;}
 +
      #top_menu_under{height: 0px;}
 +
      #globalWrapper{padding-bottom: 200px;}
 +
      </style>
  
−
<div class="column full_size">
+
      <!-- Custom Styling -->
 +
      <style>
 +
      a {list-style-image: none;}
 +
      ul {list-style-image: none;}
 +
      ol {list-style-image: none;}
 +
      li {list-style-image: none;}
 +
      </style>
  
−
<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
 
  
  
−
<h5>What should this page contain?</h5>
 
−
<ul>
 
−
<li> A clear and concise description of your project.</li>
 
−
<li>A detailed explanation of why your team chose to work on this particular project.</li>
 
−
<li>References and sources to document your research.</li>
 
−
<li>Use illustrations and other visual resources to explain your project.</li>
 
−
</ul>
 
  
 +
<style>
 +
body{
 +
  background-color: white; 
 +
    font-family: 'Open Sans', sans-serif;
 +
}
 +
.jumbotron {
 +
    background-color: white;
 +
    position: relative;
 +
}
 +
.slide{
 +
    width:100%;
 +
   
 +
    margin: 0;
 +
   
 +
}
 +
#slide0{
 +
    background-image: url("https://static.igem.org/mediawiki/2016/9/9c/T—lethbridgehs--IMG_4553_cover_and.png");
 +
    background-size:cover;
 +
    background-position: center center;
 +
    background-repeat: no-repeat;
 +
    height: 50vh;
 +
    overflow: hidden;
 +
    margin: 0;
 +
    padding-top: 5%;
 +
    background-color: #333333;
 +
}
 +
#firsttitle{
 +
    vertical-align: center;
 +
    margin-left: auto;
 +
    margin-right: auto;
 +
    text-align: left;
 +
    color: white;
 +
    vertical-align: center;
 +
position:absolute;
 +
bottom:0;
  
−
</div>
+
 
 +
font-size: 8em;
 +
}
 +
#secondtitle{
 +
    vertical-align: center;
 +
    margin-left: auto;
 +
    margin-right: auto;
 +
    text-align: center;
 +
    color: white;
 +
    vertical-align: middle;
 +
  top: 25%;
 +
font-size: 2em;
 +
}
 +
.slidesecondlist{
 +
    list-style-type: none;
 +
    margin-left: 15%;
 +
}
 +
.slidesecondlist ul{
 +
    margin: 0;
 +
    padding: 20px;
 +
    background-color: none;
 +
}
 +
#slidesecond{
  
−
<div class="column full_size" >
+
    overflow: hidden;
 +
    margin: 0;
 +
    padding-top: 0;
 +
    padding: 0;
 +
    background-color: #eee7dd;
 +
}
  
−
<h5>Advice on writing your Project Description</h5>
+
#slide_project_0{
 +
    background-image: url("https://static.igem.org/mediawiki/2016/9/9c/T—lethbridgehs--IMG_4553_cover_and.png");
 +
    background-size:cover;
 +
    background-position: center -10%;
 +
    background-repeat: no-repeat;
 +
    height: 90%;
 +
    overflow: hidden;
 +
}
 +
#slide_team_0{
 +
    background-image: url("images/IMG_4553.jpg");
 +
    background-size:cover;
 +
    background-position: center -10%;
 +
    background-repeat: no-repeat;
 +
    height: 90%;
 +
    overflow: hidden;
 +
}
 +
#slide_hp_0{
 +
    background-image: url("images/funnyteamcover.png");
 +
    background-size:cover;
 +
    background-position: center -10%;
 +
    background-repeat: no-repeat;
 +
    height: 90%;
 +
    overflow: hidden;
 +
}
 +
#slide0title{
 +
    color: white;
 +
    display: block;
 +
    margin: auto;
 +
    text-align: center;
 +
}
 +
#blooddrop{
 +
    position: absolute;
 +
    bottom: 0;
 +
    left: 0;
 +
  right: 0;
 +
  margin: 0 auto;
 +
    z-index: 1;
 +
    -webkit-animation: fadeInOut 2s infinite;
 +
    -moz-animation: fadeInOut 2s infinite;
 +
    -o-animation: fadeInOut 2s infinite;
 +
    animation: fadeInOut 2s infinite;
 +
}
 +
#slide1{
 +
    /*background-color:#eee7dd;*/
 +
    background-color:white;
 +
  /* background-image: url("images/289680_1231091663_large.jpg");
 +
    background
 +
    background-size:cover;
 +
    background-position: center center;
 +
    background-repeat: no-repeat;*/
 +
    color: black;
 +
   
 +
}
 +
#slide1Sub{
 +
    margin-left: 10%;
 +
    margin-right: 10%;
 +
   
 +
}
 +
#slide2{
 +
  /* background-image: url("images/anotherteamcover.png");*/
 +
    background-color: green;
 +
    background-size: cover;
 +
    background-position: center center;
 +
    background-repeat: no-repeat;
 +
}
 +
#slide6{
 +
   
 +
}
 +
#slide3{
 +
    background-color: #cf4848;
 +
    height: 90%;
 +
    padding-top:2%;
 +
}ding-top:1%;
 +
#slide1title{
 +
    color:red;
 +
    text-align: center;
 +
    font-size:60px;
 +
    margin-top:0%;
 +
}
 +
#slide12ndline{
 +
    color:red;
 +
    text-align: center;
 +
    font-size:50px;
 +
}
 +
#slide1para{
 +
    font-size: 1.1em;
 +
    color: black;
 +
}
 +
.logo{
 +
    float:left;
 +
    margin-left:9%;
 +
    margin-top: 1%;
 +
}
 +
.navbar-header{
 +
    margin-top:-20px;
 +
}
 +
.navbar-default{
 +
  /** box-shadow: 0px 8px 6px -6px #999;**/
 +
 +
}
 +
.navbar-default .navbar-nav>li>a {
 +
    color: white;
 +
    font-size: 15px;
 +
    padding-top:2px;
 +
    padding-top:2px;
 +
    margin-top: 12px;
 +
}
 +
.navbar-collapse.collapse {
 +
    padding-bottom: 6px;
 +
    padding-top: 3px;
 +
}
 +
.navbar-default .navbar-nav>.active>a, .navbar-default .navbar-nav>.active>a:focus, .navbar-default .navbar-nav>.active>a:hover {
 +
    color: white;
 +
    background-color: transparent;
 +
}
  
−
<p>
+
.removeNavBarColor{
−
We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.  
+
    background-color: transparent;
−
</p>
+
   
 +
}
 +
.makeNavBarColor{
 +
  /** background-color: #CC141C ;*/
 +
    background-color: #dc4640 ;
 +
   
 +
   
 +
}
  
−
<p>
+
.navbar-default .navbar-nav>li>a{
−
Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
+
    padding-top: 30px;
−
</p>
+
    margin-top: 0;
 +
    margin-bottom: 0%;
 +
    padding-bottom: 15px;
 +
    color:white;
 +
}
 +
.navbar-collapse.collapse{
 +
    padding-top: 0;
 +
    padding-bottom: 0;
 +
}
 +
@-webkit-keyframes fadeInOut{
 +
    0% { opacity: 0;}
 +
    50% { opacity: 1; }
 +
    100% { opacity:0;}
 +
}
 +
@-moz-keyframes fadeInOut{
 +
    0% { opacity: 0;}
 +
    50% { opacity: 1; }
 +
    100% { opacity:0;}
 +
}
 +
@-o-keyframes fadeInOut{
 +
    0% { opacity: 0;}
 +
    50% { opacity: 1; }
 +
    100% { opacity:0;}
 +
}
 +
@keyframes fadeInOut{
 +
    0% { opacity: 0;}
 +
    50% { opacity: 1; }
 +
    100% { opacity:0;}
 +
}
  
−
</div>
+
[class^="flaticon-"]:before, [class*=" flaticon-"]:before, [class^="flaticon-"]:after, [class*=" flaticon-"]:after {
 +
        font-family: Flaticon;
 +
        font-size: 30px;
 +
        font-style: normal;
 +
        margin-left: 0px;
 +
        color: white;
 +
   
 +
    }
  
  
−
<div class="column half_size" >
+
.glyph {
 +
        display: inline-block;
 +
        width: 9em;
 +
        margin: 1em;
 +
        text-align: center;
 +
        vertical-align: top;
 +
        background: #FFF;
 +
    float: left;
 +
    }
 +
    .glyph .glyph-icon {
 +
        display:inline-block;
 +
        float: left;
 +
       
 +
        font-family:"Flaticon";
 +
        font-size: 64px;
 +
    }
 +
.glyph .glyph-icon:before {
 +
        font-size: 64px;
 +
        color: white;
 +
        margin-left: 0;
 +
    }
  
−
<h5>References</h5>
+
.menuIcon{
−
<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
+
 +
}
 +
.active{
 +
    background-color: red;
 +
    color: white !important;
 +
}
 +
[class^="active"]:before, [class*="active"]:before, [class^="active"]:after, [class*="active"]:after {
 +
    color: white;
 +
}
 +
.menuIcon:before,
 +
.menuIcon:after { 
  
−
</div>
+
        font-size: 20px;
  
 +
}
 +
.menuIcon2:after { 
  
−
<div class="column half_size" >
+
        font-size: 40px;
−
<h5>Inspiration</h5>
+
 
−
<p>See how other teams have described and presented their projects: </p>
+
}
 +
 
 +
.coverCircle{
 +
    margin: 0;
 +
    padding: 0;
 +
    display: block;
 +
    position: absolute;
 +
    bottom: 0;
 +
    left: 0;
 +
    right: 0;
 +
    margin-left: auto;
 +
    margin-right: auto;
 +
}
 +
.sidebar{
 +
    list-style-type: none;
 +
    list-style-position: inside;
 +
    color: #cc141c;
 +
    font-size: 1em;
 +
    left: 0;
 +
    right: 0;
 +
}
 +
.sidebar li{
 +
  list-style-position: inside;
 +
    padding-top: 20px;
 +
    color: #cc141c;
 +
    font-size: 2em;
 +
 
 +
 
 +
}
 +
a:visited {
 +
    color: #cc141c;
 +
 
 +
}
 +
 
 +
.fixSideBar{
 +
    position: fixed;
 +
    top: 8%;
 +
    left: 0;
 +
    right: 0;
 +
}
 +
.removeFixSideBar{
 +
    position: absolute;
 +
    left: 0;
 +
    right: 0;
 +
}
 +
 
 +
.outerBar{
 +
    position: relative;
 +
    word-wrap:break-word;
 +
}
 +
.fixNoteBookSideBar{
 +
    position: fixed;
 +
    top: 8%;
 +
    right: 0;
 +
 
 +
}
 +
.removeFixNoteBookSideBar{
 +
   
 +
}
 +
.profilePicBox{
 +
    width: 100%;
 +
 
 +
 
 +
    background-color: red;
 +
    margin-top: 10px;
 +
    padding: 0;
 +
   
 +
}
 +
.profilePicBox img{
 +
    margin: 0;
 +
    padding: 0;
 +
   
 +
}
 +
.profileInfoBox{
 +
    display: none;
 +
    background-color: white;
 +
    position: absolute;
 +
    z-index: 1000;
 +
    width: 100%;
 +
    height: 100%;
 +
    padding-right: 2em;
 +
}
 +
.showInfoBox{
 +
    display: block;
 +
}
 +
.makeGray{
 +
    -webkit-filter: grayscale(100%);
 +
    filter: grayscale(100%);
 +
}
 +
.noteBookMonthLabels{
 +
    margin: left:3%;
 +
}
 +
#datelist{
 +
    display: none;   
 +
}
 +
#dateList li{
 +
    list-style-type: none;
 +
    font-size: 1em;
 +
}
 +
.notebookSidebar{
 +
    width: inherit;
 +
}
 +
.notebookSideBar h1{
 +
    padding-top:5px;
 +
    padding-bottom: 5px;
 +
    font-size: 2em;
 +
}
 +
.notebookIcon {
 +
font-size: 0px;
 +
cursor: pointer;
 +
width: auto;
 +
height: auto;
 +
text-align: center;
 +
position: relative;
 +
z-index: 1;
 +
color: #fff;
 +
margin-left:auto;
 +
margin-right:auto;
 +
 
 +
}
 +
 
 +
 
 +
.notebookIcon:before {
 +
font-family: 'Flaticon';
 +
speak: none;
 +
font-size: 35px;
 +
line-height: 35xp;
 +
font-style: normal;
 +
font-weight: normal;
 +
font-variant: normal;
 +
text-transform: none;
 +
    color: white;
 +
display: block;
 +
-webkit-font-smoothing: antialiased;
 +
text-align:center;
 +
margin-left:auto;
 +
margin-right:auto;
 +
    vertical-align: center;
 +
    position: relative;
 +
    top:5%;
 +
    transform: translateY(-5%);
 +
}
 +
/*****************************************Time line*********************************/
 +
.timeline{
 +
    list-style: none;
 +
    position: relative;
 +
}
 +
 
 +
.timeline li{
 +
    position: relative;
 +
}
 +
.tl_month{
 +
    width: 100%;
 +
    height: 50px;
 +
    background-color: #ee4d4d;
 +
    margin-bottom: 15px;
 +
      vertical-align: center;
 +
    padding-top: 0.75%;
 +
    padding-left: auto;
 +
    padding-right: auto;
 +
    color:white;
 +
}
 +
.tl_month h2{
 +
    float:inherit;
 +
    margin-top: auto;
 +
    margin-bottom: auto;
 +
    color: white;
 +
}
 +
.tl_time {
 +
    display: block;
 +
    width: 25%;
 +
    margin-top:2%;
 +
    padding-right: 100px;
 +
    position: absolute;
 +
    font-size:20;
 +
    color:#ee4d4d;
 +
}
 +
/**************************How to make font size on notebook responsive*******/
 +
.tl_label{
 +
    margin-bottom: 15px;
 +
    margin-left: 25%;
 +
    color: black;
 +
    border: 3px solid #ee4d4d;
 +
    position: relative;
 +
    border-radius: 5px;
 +
    background: white;
 +
    padding-left: 2%;
 +
    padding-right: 2%;
 +
    cursor: pointer;
 +
}
 +
.tl_label h2{
 +
    margin-bottom: 15px;
 +
    font-size: 1.3em;
 +
}
 +
.tl_label:before{
 +
    right: 100%;
 +
    border: solid transparent;
 +
    content: '';
 +
    height: 0;
 +
    width: 0;
 +
    position: absolute;
 +
    pointer-events: none;
 +
    border-right-color: #ee4d4d;
 +
    border-width: 1vw;
 +
    /*top: 1vw;*/
 +
}
 +
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<li><a href="https://2014.igem.org/Team:Imperial/Project"> Imperial</a></li>
 
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> UC Davis</a></li>
 
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<h3>Background Information<h3/>
 +
<p><font size="3.5">This year our team has decided to focus on increasing the speed and overall efficiency of blood coagulation in medium to large sized wounds. Although there are other products currently available in the market to increase the rate of blood coagulation, such as Quikclot (Z-Medica, 2014), or VetiGel (Bloomberg, 2014), our product is significantly different from these. Our product, called “Coagu.coli”, is based on using a component from the snake venom of the Desert Horned Viper (Cerastes cerastes).</p>
 +
<p> <br><img src="https://static.igem.org/mediawiki/2016/b/ba/T--Lethbridge_HS--cerastes.jpg"><br/><font size="3.5"> Certain components of snake venoms are able to bypass several steps of the blood clotting cascade, therefore increasing the speed of blood clotting (Braud, 2000; Castro, Zingali, Albuquerque, Pujol-Luz, & Rodrigues, 2004).</p>
 +
<p> <br><img src="https://static.igem.org/mediawiki/2016/d/d5/T--Lethbridge_HS--clotting_pathway.jpg "><br/><font size="3.5">The component we are utilizing is Cerastotin and this is a serine protease that has thrombin like properties. What sets Cerastotin apart from other serine proteases is that it is easy to express and small enough to be used in our construct. Thrombin is an enzyme that causes the conversion of fibrinogen to fibrin, which leads to the formation of a clot (Smith, 1980; Wolberg, 2007). By using Cerastotin in our construct, we are therefore able to greatly increase the efficiency and speed of blood coagulation.</p>
 +
<p><font size="3.5"> Our product would be applied by a syringe containing our construct followed by a bandage for sealing it in place, and could be used in a variety of situations. Because our product would be produced in E.Coli, it would be highly affordable as a great amount can be expressed in a short period of time. The military, hospitals, and the average person would find our product invaluable. Coagu.coli has the power to prevent death by severe blood loss by giving a person enough time to receive further medical attention.</p>
 +
<h3>References</h3>
 +
<p>Bloomberg (2014, November 18). VetiGel: The band-aid of the future stops bleeding instantlyRetrieved from https://www.youtube.com/watch?v=dJLxRcU9No4</p>
 +
<p>Braud, S. (2000). Snake venom proteins acting on hemostasis. Biochimie, 82(9-10), 851–859. doi:10.1016/s0300-9084(00)01178-0</p>
 +
<p>Castro, H. C., Zingali, R. B., Albuquerque, M. G., Pujol-Luz, M., & Rodrigues, C. R. (2004). Snake venom thrombin-like enzymes: From reptilase to now. Cellular and Molecular Life Sciences (CMLS),61(7-8), 843–856. doi:10.1007/s00018-003-3325-z</p>
 +
<p>Smith, G. F. (1980). Fibrinogen–fibrin conversion. The mechanism of fibrin-polymer formation in solution. Biochemical Journal, 185(1), 1–11. doi:10.1042/bj1850001</p>
 +
<p>Wolberg, A. S. (2007). Thrombin generation and fibrin clot structure. Blood Reviews, 21(3), 131–142. doi:10.1016/j.blre.2006.11.001</p>
 +
<p>Z-Medica. (2014). QuikClot® - stop bleeding fast. Retrieved October 16, 2016, from http://www.quikclot.com/</p>
  
  
  
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Latest revision as of 03:15, 20 October 2016

Lethbridge HS iGEM 2016

DESCRIPTION

Background Information

This year our team has decided to focus on increasing the speed and overall efficiency of blood coagulation in medium to large sized wounds. Although there are other products currently available in the market to increase the rate of blood coagulation, such as Quikclot (Z-Medica, 2014), or VetiGel (Bloomberg, 2014), our product is significantly different from these. Our product, called “Coagu.coli”, is based on using a component from the snake venom of the Desert Horned Viper (Cerastes cerastes).



Certain components of snake venoms are able to bypass several steps of the blood clotting cascade, therefore increasing the speed of blood clotting (Braud, 2000; Castro, Zingali, Albuquerque, Pujol-Luz, & Rodrigues, 2004).



The component we are utilizing is Cerastotin and this is a serine protease that has thrombin like properties. What sets Cerastotin apart from other serine proteases is that it is easy to express and small enough to be used in our construct. Thrombin is an enzyme that causes the conversion of fibrinogen to fibrin, which leads to the formation of a clot (Smith, 1980; Wolberg, 2007). By using Cerastotin in our construct, we are therefore able to greatly increase the efficiency and speed of blood coagulation.

Our product would be applied by a syringe containing our construct followed by a bandage for sealing it in place, and could be used in a variety of situations. Because our product would be produced in E.Coli, it would be highly affordable as a great amount can be expressed in a short period of time. The military, hospitals, and the average person would find our product invaluable. Coagu.coli has the power to prevent death by severe blood loss by giving a person enough time to receive further medical attention.

References

Bloomberg (2014, November 18). VetiGel: The band-aid of the future stops bleeding instantlyRetrieved from https://www.youtube.com/watch?v=dJLxRcU9No4

Braud, S. (2000). Snake venom proteins acting on hemostasis. Biochimie, 82(9-10), 851–859. doi:10.1016/s0300-9084(00)01178-0

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