Difference between revisions of "Team:Lethbridge HS/Proof"

 
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                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Description">DESCRIPTION</a>
 
                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Description">DESCRIPTION</a>
 
                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Design">DESIGN</a>
 
                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Design">DESIGN</a>
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<a href="https://2016.igem.org/Team:Lethbridge_HS/Prototype">PROTOTYPE</a>
 
<a href="https://2016.igem.org/Team:Lethbridge_HS/Proof">PROOF OF CONCEPT</a>
 
<a href="https://2016.igem.org/Team:Lethbridge_HS/Proof">PROOF OF CONCEPT</a>
 
                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Experiments">EXPERIMENTS</a>
 
                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Experiments">EXPERIMENTS</a>
 
                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Results">RESULTS</a>
 
                                     <a href="https://2016.igem.org/Team:Lethbridge_HS/Results">RESULTS</a>
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<a href="https://2016.igem.org/Team:Lethbridge_HS/Achievements">ACHIEVEMENTS</a>
 
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                        <li><a href="https://2016.igem.org/Team:Lethbridge_HS/Notebook" style="" class="menuitem" style="margin:0; padding:0;">NOTEBOOK</a></li>
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                            <a href="#" class="dropdown-toggle" data-toggle = "dropdown">NOTEBOOK<b class="caret"></b></a>
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                                    <a href="https://2016.igem.org/Team:Lethbridge_HS/Notebook">NOTEBOOK</a>
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<a href="https://2016.igem.org/Team:Lethbridge_HS/Methods">METHODS</a>
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                         <li><a href="https://2016.igem.org/Team:Lethbridge_HS/Safety" style="" class="menuitem" style="margin:0; padding:0; ">SAFETY</a></li>
 
                         <li><a href="https://2016.igem.org/Team:Lethbridge_HS/Safety" style="" class="menuitem" style="margin:0; padding:0; ">SAFETY</a></li>
 
                                                  
 
                                                  
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<h3>Market Research</h3>
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<h3>Lab Proof of Concept</h3>
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<p>As shown below in the video, the blood with our construct added successfully clotted faster than blood without our construct. Our construct effectively clotted blood faster than the natural clotting process, showing that our project has the potential to save time in an emergency situation.</p>  
 
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<p>In order to understand what types of products are available or that are in the testing phase, our team did some research to look at how we could design our product to improve upon the issues in the products we found.</p>
 
  
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<p>The above table shows a comparison between Coagu.coli and blood coagulants that are currently in the market. As you can see, most of these products are not available to be used yet, and are not affordable. Looking at each coagulant more specifically though, we can recognize the faults present in each:</p>
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<p>QuikClot: According to the official QuikClot website, this coagulant intercepts in the natural blood clotting cascade at the very beginning. It uses a substance known as kaolin, which starts the clotting process with the activation of factor XII. Since this factor is located at the start of the clotting cascade, this product will not be as “quick” as the name suggests (Z-Medica, 2014). QuikClot has also been known to be troublesome to remove from a wound after application as the material can become too hard if it is left too long in the wound. Bleeding can also resume after removal (NurseAmyandDrBones, 2015).</p>
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<p>VetiGel:This coagulant seems to be the best out of all the others. It is fast and affordable. The only problem is that it is not yet ready to be revealed in the market for human use, and has only been focused on being used in veterinarian clinics on animals (Weller, 2014).</p>
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<p>Tisseel: Although this factor has not been included in the table, Tisseel is known to be made from substances made of human plasma, which “can contain infectious agents”(Center & Evaluation, 2014) and transmit diseases. Looking into the other faults that this coagulant contains, Tisseel is not available to be used in a home setting by an individual. Instead, it is supposed to be applied by a healthcare professional in a medical setting (Drugs, n.d.). And since Tisseel is a fibrin sealant, it is found to be more expensive than other types of coagulants (2009). </p>
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<p>Duraseal and Floseal: These are both surgical compounds and would not be beneficial to an individual for use on a normal wound. (Corporation, 2016; pdriscoll, 2015).</p>
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<p>Xyntha: This coagulant is only useful to people with a deficiency of factor VIII (classic hemophilia), and isn’t useful to other types of hemophilia or Von Willebrand's disease (Pfizer Inc, 2016). </p>
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<p>Overall, the table shows just why our product Coagu.coli is the perfect coagulant. </p>
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<h3>References</h3>
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<p>Center, & Evaluation, B. (2014, December 31). Product information. Retrieved October 16, 2016, from http://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/ucm089262.htm</p>
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<p>Corporation, B. H. (2016). FLOSEAL Hemostatic matrix. Retrieved October 16, 2016, from http://www.floseal.com/us/</p>
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<p>Drugs. Tisseel medical facts from drugs.Com. Retrieved October 16, 2016, from https://www.drugs.com/mtm/tisseel.html </p>
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<p>hemostatguy@gmail.com. (2009, June 14). Medical Hemostat. Retrieved October 16, 2016, from http://medicalhemostat.blogspot.ca/2009/06/hemostasis-market-review-of-gelfoam.html</p>
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<p>NurseAmyandDrBones. (2015, September 25). Celox and Quikclot to control bleeding. Retrieved October 16, 2016, from active shooter, https://www.doomandbloom.net/celox-and-quikclot-to-control-bleeding/</p>
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<p>Pfizer, Inc. (2016, February ). Home. Retrieved October 16, 2016, from http://www.xyntha.com/</p>
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<p>pdriscoll. (2015, May 4). Synthetic surgical sealants | | advanced medical technologies. Retrieved October 16, 2016, from http://blog.mediligence.com/2015/05/04/synthetic-surgical-sealants/</p>
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<p>Weller, C. (2014, November 20). Tomorrow’s band-aid stops bleeding instantly [VIDEO]. Innovation. Retrieved from http://www.medicaldaily.com/pulse/vetigel-stops-bleeding-seconds-polymer-could-be-band-aid-future-311514</p>
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<p>Z-Medica. (2014). QuikClot® - stop bleeding fast. Retrieved October 16, 2016, from http://www.quikclot.com/</p>
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Latest revision as of 03:48, 20 October 2016

Lethbridge HS iGEM 2016

PROOF OF CONCEPT

Lab Proof of Concept

As shown below in the video, the blood with our construct added successfully clotted faster than blood without our construct. Our construct effectively clotted blood faster than the natural clotting process, showing that our project has the potential to save time in an emergency situation.