Difference between revisions of "Team:CGU Taiwan"

 
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<html>
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<meta http-equiv="X-UA-Compatible" content="IE=edge">
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<style>
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<head>
 
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nav ul li:hover a {
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position: absolute; top: 100%;
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nav ul ul li a {
 
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padding: 15px 40px;
 
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color: #fff;
 
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nav ul ul li a:hover {
 
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background: #4b545f;
 
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.header-subnav {
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  float: none;
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.header-subnav li {
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  float: none;
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  display: inline-block;
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.header-subnav li a {
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  padding: 13px 1rem;
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.header-subnav li a.is-active {
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.header-subnav li a:hover {
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}
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.fixed1 {
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.page {
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.end {
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  background-color:#0D014D;
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  position: absolute;
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  height: 30%;
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  font-family: Corbel;
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hr {
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  border: 0;
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}
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.end2 {
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  background-color:#0D014D;
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  font-family: Corbel;
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}
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.sitemap {
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  background-color:#0D014D;
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  font-family: Corbel;
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}
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.list li {
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  background-repeat:no-repeat;
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  background-position:10px;
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  background-size:9%;
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  margin-bottom:-20%;
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}
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.list2 li {
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  list-style:none;
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  background-repeat:no-repeat;
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  background-position:6px;
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  background-size:7%;
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  margin-bottom:-10%;
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}
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.list3 li {
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  list-style:none;
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  background-image:url(https://static.igem.org/mediawiki/2016/3/31/CGU_Taiwan--sitemap3.jpg);
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  background-repeat:no-repeat;
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  background-position:5%;
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  background-size:2%;
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  margin-bottom:-10%;
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}
 
</style>
 
</style>
 
</head>
 
</head>
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<nav>
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−
<ul>
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<script>
−
  <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Home">HOME</a></li>
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/* Dynamic top menu positioning
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<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Team">TEAM</a></li>
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  *
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<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Project">PROJECT</a>
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*/
−
    <ul>
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var num = 110; //number of pixels before modifying styles
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        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Description">DESCRIPTION</a></li>
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$(window).bind('scroll', function () {
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        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Design">DESIGN</a></li>
+
    if ($(window).scrollTop() > num) {
−
        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Proof">PROOF</a></li>
+
        $('.header-subnav').addClass('fixed1');
−
    </ul>
+
    } else {
−
</li>
+
        $('.header-subnav').removeClass('fixed1');
−
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Wet Lab">WET LAB</a>
+
    }
−
    <ul>
+
});
−
        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Experiments">EXPERIMENTS</a></li>
+
 
−
        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Schedule">SCHEDULE</a></li>
+
 
−
        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Results">RESULTS</a></li>
+
//USE SCROLL WHEEL FOR THIS FIDDLE DEMO
−
    </ul>
+
</script>
−
</li>
+
 
−
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Model">MODELING</a>
+
<body>
−
    <ul>
+
<a name='anchor1'></a>
−
        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Software">SOFTWARE</a></li>
+
<div class="top">
−
    </ul>
+
<img style="margin-top:-2%;width:100%;height:140%;position:absolute;" src="https://static.igem.org/mediawiki/2016/0/0b/CGU_Taiwan--top.jpg">
−
</li>
+
</div>
−
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Human_Practices">HUMAN PRACTICES</a></li>
+
 
−
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Attributions">ATTRIBUTION</a></li>
+
<header class="top">
−
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Notebook">NOTEBOOK</a>
+
    <div class="header-subnav">
−
    <ul>
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan">HOME</a></li>
−
        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Safety">SAFETY</a></li>
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Achievements">ACHIEVEMENTS</a></li>
−
        <li><a href="https://2016.igem.org/Team:CGU_Taiwan/News">NEWS</a></li>
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Description">PROJECT</a></li>
−
    </ul>
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Software">MODELING</a></li>
−
</li>
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Human_Practices">HUMAN PRACTICES</a></li>
−
</ul>
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Team">PEOPLE</a></li>
−
</nav>
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Interlab">INTERLAB</a></li>
−
<div class="slideshow-container">
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Safety">SAFETY</a></li>
−
  <div class="mySlides fade">
+
    <li><a href="https://2016.igem.org/Team:CGU_Taiwan/Parts">PARTS</a></li>
−
    <div class="numbertext">1 / 3</div>
+
−
    <img src="Chang Gung university/jpeg" style="width:100%">
+
−
    <div class="text">Caption Text</div>
+
 
   </div>
 
   </div>
−
  <a class="prev" onclick="plusSlides(-1)">&#10094;</a>
+
</header>
−
  <a class="next" onclick="plusSlides(1)">&#10095;</a>
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<br><br><br>
 +
<div>
 +
<br><br><br><br>
 +
<video margin-top="5%" width="100%" height="700px" controls  autoplay>
 +
<source src="https://static.igem.org/mediawiki/2016/4/41/CGU_Taiwan--video4.mp4" type="video/mp4">
 +
</video>
 
</div>
 
</div>
 +
 +
<br><br><br>
 +
<div class="mid">
 +
<div style="font-size:60px;color:#140731;text-decoration:none;margin-left:45%;">
 +
<br><br><br><br>
 +
Abstract
 +
</div>
 +
<br></br>
 +
<br></br>
 +
<b style="color:black;font-size:25px;margin-left:10%;">Leijuvant- A Revolutionary Choice of Vaccine Helper</b><br><br>
 +
<div style="color:black;font-size:18px;margin-left:10%;text-align:justify;">
 +
For many infectious diseases that still don’t have an effective vaccine, enhancing T cell immune response may be the key point to solve this problem. Leijuvant represents a whole new perspective of adjuvant that uses Leishmania as an effective T cell stimulator. Leishmania is a parasite that specifically lives within macrophage, a professional antigen presenting cell (APC). As a potential vaccine adjuvant, Leishmania possess many advantages, including APC recruitment, pattern recognition receptor (PRR) activation, inflammasome activation, activation of MHC-presenting pathway and most important of all, T cell activation. Genetically-engineered Leishmania that can be inactivated by light exposure acts as a safe carrier to deliver specific antigens to APCs for activation of T cells and B cell stimulation. Based on this concept, we established a new model system to generate antigen-specific Leishmania adjuvant-- Leijuvant. We further designed a user-friendly MHC peptide prediction software to integrate key protein information and optimize the presentation of antigen peptides by MHC molecules. Our ultimate goal is to introduce Leijuvant as an effective, safe, and antigen-specific adjuvant to the vaccine industry and the general public.
 +
</div>
 +
<br><br>
 +
</div>
 +
 +
<div class="mid2" style="background-color:#d0d0d0;top:130%;">
 +
<div style="font-size:60px;color:#140731;margin-left:35%;margin-top:2%;">
 
<br>
 
<br>
 +
Start the Journey
 +
</div>
 +
<br></br>
 +
<br></br>
 +
<a href="https://2016.igem.org/Team:CGU_Taiwan/Description"><img style="border-radius:50%;border:10px solid #140731;padding:5px;width:20%;height:25%;position:absolute;margin-left:10%;" src="https://static.igem.org/mediawiki/2016/4/40/CGU_Taiwan--t4.jpg">
 +
<h2 style="font-size:35px;color:#140731;position:absolute;left:15%;top:490px;z-index:+1;text-decoration:none;">PROJECT</h2></a>
 +
<a href="http://facebook.com/igemcgu"><img style="border-radius:50%;border:10px solid #140731;padding:5px;width:20%;height:25%;position:absolute;margin-left:38%;" src="https://static.igem.org/mediawiki/2016/c/cd/CGU_Taiwan--macrophage.jpg">
 +
<h3 style="font-size:35px;color:#140731;position:absolute;left:45%;top:490px;text-decoration:none;">NEWS</h3></a>
 +
<a href="https://2016.igem.org/Team:CGU_Taiwan/Results"><img style="border-radius:50%;border:10px solid #140731;padding:5px;width:20%;height:25%;position:absolute;margin-left:66%;" src="https://static.igem.org/mediawiki/2016/7/7c/CGU_Taiwan--HA.jpg">
 +
<h4 style="font-size:35px;color:#140731;position:absolute;left:72%;top:490px;text-decoration:none;">RESULTS</h4></a>
 +
</div>
  
−
<div style="text-align:center">
+
<div class="end" style="top:190%;">
−
  <span class="dot" onclick="currentSlide(1)"></span>  
+
<div style="font-size:20px;color:white;text-decoration:none;margin-left:20%;margin-top:5%;">
−
  <span class="dot" onclick="currentSlide(2)"></span>  
+
Chang Gung University
−
  <span class="dot" onclick="currentSlide(3)"></span>
+
 
</div>
 
</div>
 +
<br>
 +
<div style="color:white;font-size:15px;margin-left:10%;text-align:justify;">
 +
No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan (R.O.C.)
 +
<br>
 +
TEL: +886-3-2118800 FAX:+886-3-2118700
 +
<img src="https://static.igem.org/mediawiki/2016/e/eb/CGU_Taiwan--sponsor0.6.jpg" style="position:absolute;top:0%;margin-left:25%;width:35%;height:45%;margin-top:3%;">
 +
</div>
 +
</div>
 +
<br><br><br><br><br>
 +
 +
<div class="end2" style="top:210%;">
 +
<br>
 +
<ul class="list3" class="margin-left:1%;margin-top:2%;">
 +
<li><a href="#anchor1"><b style="color:white;font-size:28px;margin-left:7%;">TOP</a></li>
 +
</ul>
 +
<br>
 +
<div class="sitemap" style="margin-left:5%;">
 +
<br>
 +
<b style="color:white;font-size:28px;margin-top:5%;margin-left:4%;text-decoration:none;">SITE MAP</b><br>
 +
<br><br>
 +
<img style="background-color:#0D014D;margin-left:20%;border-radius:50%;border:6px solid white;padding:5px;width:50%;height:90%;position:absolute;margin-left:2%;" src="https://static.igem.org/mediawiki/2016/0/03/CGU_Taiwan--leishmania3.jpg">
 +
</div>
 +
 +
<div class="sitemap" style="margin-left:22%;margin-top:-1%;">
 +
<ul class="list" class="margin-left:5%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan"><b style="color:white;font-size:18px;margin-left:20%;">HOME</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Achievements"><b style="color:white;font-size:18px;margin-left:20%;">ACHIEVEMENTS</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Interlab"><b style="color:white;font-size:18px;margin-left:20%;">INTERLAB</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Safety"><b style="color:white;font-size:18px;margin-left:20%;">SAFETY</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Parts"><b style="color:white;font-size:18px;margin-left:20%;">PARTS</li></a>
 +
</ul>
 +
</div>
 +
 +
<div class="sitemap" style="margin-left:40%;margin-top:-2%;">
 +
<ul class="list" class="margin-left:5%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Description"><b style="color:white;font-size:18px;margin-left:20%;">PROJECT</li></a>
 +
<br><br>
 +
<ul class="list2" class="margin-left:6%;margin-top:50%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Design"><b style="color:white;font-size:17px;margin-left:10%;">Design</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Background"><b style="color:white;font-size:17px;margin-left:10%;">Background</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Results"><b style="color:white;font-size:17px;margin-left:10%;">Results</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Proof"><b style="color:white;font-size:17px;margin-left:10%;">Proof</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Notebook"><b style="color:white;font-size:17px;margin-left:10%;">Notebook</li></a>
 +
<br><br>
 +
</ul>
 +
</ul>
 +
</div>
 +
 +
<div class="sitemap" style="margin-left:55%;margin-top:-3.5%;">
 +
<ul class="list" class="margin-left:5%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Human_Practices"><b style="color:white;font-size:18px;margin-left:20%;">HUMAN PRACTICES</li></a>
 +
<br><br>
 +
<ul class="list2" class="margin-left:6%;margin-top:50%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Human_Practices_Survey"><b style="color:white;font-size:17px;margin-left:10%;">Survey</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Human_Practices_Education"><b style="color:white;font-size:17px;margin-left:10%;">Education</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Human_Practices_Communication"><b style="color:white;font-size:17px;margin-left:10%;">Communication</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Entrepreneurship"><b style="color:white;font-size:17px;margin-left:10%;">Entrepreneurship</li></a>
 +
</ul>
 +
</ul>
 +
</div>
 +
 +
<div class="sitemap" style="margin-left:75%;margin-top:-3.5%;">
 +
<ul class="list" class="margin-left:5%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Software"><b style="color:white;font-size:18px;margin-left:20%;">MODELING</li></a>
 +
<br><br>
 +
<ul class="list2" class="margin-left:6%;">
 +
<li><a href="http://163.25.92.36/igemcgu/igemwebhome.htm"><b style="color:white;font-size:17px;margin-left:10%;">McHug</li></a>
 +
</ul>
 +
</ul>
 +
<ul class="list" class="margin-left:1%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Team"><b style="color:white;font-size:18px;margin-left:20%;">OUR TEAM</li></a>
 +
<br><br>
 +
<ul class="list2" class="margin-left:6%;margin-top:-5%;">
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Collaborations"><b style="color:white;font-size:17px;margin-left:10%;">Collaborations</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Attributions"><b style="color:white;font-size:17px;margin-left:10%;">Attributions</li></a>
 +
<li><a href="https://2016.igem.org/Team:CGU_Taiwan/Team#anchor2"><b style="color:white;font-size:17px;margin-left:10%;">Sponsors</li></a>
 +
</ul>
 +
</ul>
 +
</div>
 +
 +
 +
</div>
 +
 +
 
</html>
 
</html>

Latest revision as of 07:04, 2 December 2016

  • HOME
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    • Abstract




    Leijuvant- A Revolutionary Choice of Vaccine Helper

    For many infectious diseases that still don’t have an effective vaccine, enhancing T cell immune response may be the key point to solve this problem. Leijuvant represents a whole new perspective of adjuvant that uses Leishmania as an effective T cell stimulator. Leishmania is a parasite that specifically lives within macrophage, a professional antigen presenting cell (APC). As a potential vaccine adjuvant, Leishmania possess many advantages, including APC recruitment, pattern recognition receptor (PRR) activation, inflammasome activation, activation of MHC-presenting pathway and most important of all, T cell activation. Genetically-engineered Leishmania that can be inactivated by light exposure acts as a safe carrier to deliver specific antigens to APCs for activation of T cells and B cell stimulation. Based on this concept, we established a new model system to generate antigen-specific Leishmania adjuvant-- Leijuvant. We further designed a user-friendly MHC peptide prediction software to integrate key protein information and optimize the presentation of antigen peptides by MHC molecules. Our ultimate goal is to introduce Leijuvant as an effective, safe, and antigen-specific adjuvant to the vaccine industry and the general public.



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    Chang Gung University

    No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan (R.O.C.)
    TEL: +886-3-2118800 FAX:+886-3-2118700








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