Difference between revisions of "Team:Lubbock TTU"

 
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<h2> Project Background </h2>
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<p>In 2010, it was estimated that 6.5 million people in the United States alone suffered from chronic wounds, accruing an annual cost of about $2.5 billion. Furthermore, experts predict that the burden of chronic wounds will increase rapidly in the near future due to increasing medical costs, an aging population, and the emergence of antibiotic resistant bacteria.</p>
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<p>A chronic wound is considered a wound that does not heal in an orderly set of stages or within a time period of about three months. The etiology of chronic wounds is very diverse. One of the most prevalent reasons patients have persistent chronic wounds is that their bodies produce too many proteases at the wound site. In turn, these proteases degrade the extracellular matrix of the wound site which acts as a scaffold for new cells to migrate and grow. Proteases have also been shown to decrease healing rates by degrading growth factors that are needed for recruiting wound healing cells and inducing cellular proliferation.</p>
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<p>Wound healing progresses through three successive stages known as inflammation, proliferation, and remodeling. Ultimately, the degradation of the extracellular matrix and growth factor cause the wound to remain stuck in the inflammation phase, thus unable to heal.</p>
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Thanks for visiting Lubbock_TTU's wiki site! We are currently under construction but feel free to look around. You can also visit us at our Facebook page <a href="https://www.facebook.com/iGEM-Raiders-911037505685471/"><u>here</u></a>.
 
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<h2> Project Description </h2>
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<p>We will use synthetic biology principles to help treat chronic wounds by targeting the
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overproduction of wound site protease.</p>
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                <h1>Enhanced Wound Healing Using a Protein-Infused Collagen Scaffold</h1>
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                <h2>Lubbock_TTU &middot; Texas Tech University</h2>
  
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                <div id="continue"> <a href="#projintro" class="fa fa-chevron-down"></a></div>
  
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<LI>For Aim 1 we will genetically engineer E. coli to produce a protease inhibitor and platelet
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derived growth factor.
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<LI>For Aim 2 we will purify the protease inhibitor and platelet derived growth factor in a
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bioreactor.
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                <font color="#5d5d5d"><h3>About Us</h3></font>
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<font color="#5d5d5d">The Lubbock_TTU Team is part of a student organization at Texas Tech University known as iGEM Raiders. Our mission is to expose the university and community to synthetic biology through undergraduate initiative and involvement in the International Genetically Engineering Machine (iGEM) Competition.  
  
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<LI>For Aim 3 we will design a collagen bandage that mimics the human extracellular matrix, and
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</br></br>This year, the iGEM Raiders team is composed of 14 dedicated undergraduate and graduate students with backgrounds in microbiology, animal science, cell and molecular biology, biochemistry, mathematics, physics, and chemical, mechanical, and electrical engineering. The diversity within our team enables the iGEM Raiders to tackle novel project ideas.
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infuse it with purified protease inhibitor and platelet derived growth factor.
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                    <div id="readmore"><a href="https://2016.igem.org/Team:Lubbock_TTU/Team">Read more →</a></div><br></br>
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                <h3>Quick Links</h3>
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                <a href="https://2016.igem.org/Team:Lubbock_TTU/Description">Project Overview</a>
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                <a href="https://2016.igem.org/Team:Lubbock_TTU/Proof">Proof of Concept</a>
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                <a href="https://2016.igem.org/Team:Lubbock_TTU/Notebook">Project Progress</a>
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                <a href="https://2016.igem.org/Team:Lubbock_TTU/Results">Project Results</a>
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<p>Our approach is two-fold. By infusing the collagen extracellular matrix with platelet derived
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growth factor and protease inhibitor, chronic wounds should be able to progress past the
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inflammation phase and begin healing once again.</p>
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<a href='https://www.depts.ttu.edu/sga/'>
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<img src="https://static.igem.org/mediawiki/2016/6/65/T--Lubbock_TTU--mrdna.png" class="" width="21%" height=""></img</a>
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<a href='http://www.ttuhsc.edu/'>
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<img src="https://static.igem.org/mediawiki/2016/8/8c/T--Lubbock_TTU--ttuhsc.png" class="" width="21%" height=""></img></a>
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<a href='http://www.ulabstx.org/'>
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<a href='http://www.ciser.ttu.edu/'>
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<img src="https://static.igem.org/mediawiki/2016/6/6d/T--Lubbock_TTU--ciser.jpg" class="" width="120px" height="x"></img></a>
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<a href='http://www.ni.com/en-us.html'>
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<img src="https://static.igem.org/mediawiki/2016/c/c2/T--Lubbock_TTU--na.png" class="" width="25%" height=""></img></a>
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<a href='http://www.rtlgenomics.com/'>
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<img src="https://static.igem.org/mediawiki/2016/8/8e/T--Lubbock_TTU--rtlg.png" class="" width="" height=""></img></a>
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<h5>Before you start: </h5>
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Lubbock_TTU &middot; Texas Tech University
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<p> Please read the following pages:</p>
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<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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<li> <a href="https://2016.igem.org/Resources/Template_Documentation"> Template Documentation </a></li>
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<h5> Styling your wiki </h5>
 
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
 
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
 
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<h5> Wiki template information </h5>
 
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
 
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<h5> Editing your wiki </h5>
 
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
 
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
 
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
 
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
 
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
 
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<h5>Inspiration</h5>
 
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
 
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
 
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
 
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
 
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
 
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
 
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
 
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<h5> Uploading pictures and files </h5>
 
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Latest revision as of 16:45, 16 December 2016

About Us
The Lubbock_TTU Team is part of a student organization at Texas Tech University known as iGEM Raiders. Our mission is to expose the university and community to synthetic biology through undergraduate initiative and involvement in the International Genetically Engineering Machine (iGEM) Competition.

This year, the iGEM Raiders team is composed of 14 dedicated undergraduate and graduate students with backgrounds in microbiology, animal science, cell and molecular biology, biochemistry, mathematics, physics, and chemical, mechanical, and electrical engineering. The diversity within our team enables the iGEM Raiders to tackle novel project ideas.