Difference between revisions of "Team:British Columbia/Project/Consortia"

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                     <li><a href="#Key-Achievements">Key Achievements</a></li>
 
                     <li><a href="#Key-Achievements">Key Achievements</a></li>
 
                     <li><a href="#Introduction">Introduction</a></li>
 
                     <li><a href="#Introduction">Introduction</a></li>
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                    <li><a href="#Design">Design</a></li>
 
 
                     <li><a href="#Methods">Methods</a></li>
 
                     <li><a href="#Methods">Methods</a></li>
 
                     <li><a href="#Results">Results</a></li>
 
                     <li><a href="#Results">Results</a></li>
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                 <section id="Abstract" class="anchor">
 
                 <section id="Abstract" class="anchor">
 
                     <h2>Abstract</h2>
 
                     <h2>Abstract</h2>
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                     <p> Microorganisms live in complex microbial communities in the wild, in which individual species with specialized functions interact and cooperate with each other to perform complex metabolic functions. Following nature's examples, there is an increasing trend in using microbial communities for biotechnological application due to their robustness and the ability to perform complex metabolic tasks through the division of labor. Construction of synthetic microbial communities allows to compartmentalize and optimize metabolic functions in different hosts.
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                     <p>  
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The goal of our project is to design a stable, robust microbial community for the production of valuable compounds from lignocellulosic biomass. The metabolic processes are split between biomass-degrading bacteria and the production bacteria, which transforms the degradation products into valuable products. For the first part, we engineered <i>Caulobacter</> displaying functional biomass-transforming enzymes that act on cellulose. For the second part, we engineered <i>E.coli</i> producing β-carotene as a proof of concept. Now we need to confirm that these two bacteria can be co-cultured together to generate a stable consortia for consolidated bioprocessing.
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                     </p>
 
                     </p>
 
                 </section>
 
                 </section>
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                 </section>
 
                 </section>
  
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                 <section id="section-2" class="anchor">
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                 <section id="Key Achievements" class="anchor">
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                     <h2>Section 2 </h2>
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                     <h2>Key Achievements </h2>
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                     <p>"Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?"</p>
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                     <p></p>
 
                 </section>
 
                 </section>
  
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                 <section id="section-3" class="anchor">
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                 <section id="Introduction" class="anchor">
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                     <h2>Section 3 </h2>
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                     <h2>Introduction</h2>
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                     <p>"But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?"</p>
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                     <p>Microorganisms live in complex microbial communities in the wild, in which individual species with specialized phenotypes interact and cooperate with each other to perform complex metabolic functions. Following nature's examples, there is an increasing trend in using microbial communities for biotechnological application due to their robustness and the ability to perform complex metabolic tasks through the division of labor. Construction of synthetic microbial communities allows to compartmentalize and optimize metabolic functions in different hosts.
 +
The goal of our project is to design a stable, robust microbial community for the production of valuable compounds from lignocellulosic biomass. The metabolic processes are split between biomass-degrading bacteria and the production bacteria, which transforms the degradation products into valuable products. For the first part, we engineered <i>Caulobacter</> displaying functional biomass-transforming enzymes that act on cellulose. For the second part, we engineered <i>E.coli</i> producing β-carotene as a proof of concept. Now we need to confirm that these two bacteria can be co-cultured together to generate a stable consortia for consolidated bioprocessing. </p>
 
                 </section>
 
                 </section>
 
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Consortia

Consortia

Abstract

Key Achievements

Introduction

Microorganisms live in complex microbial communities in the wild, in which individual species with specialized phenotypes interact and cooperate with each other to perform complex metabolic functions. Following nature's examples, there is an increasing trend in using microbial communities for biotechnological application due to their robustness and the ability to perform complex metabolic tasks through the division of labor. Construction of synthetic microbial communities allows to compartmentalize and optimize metabolic functions in different hosts. The goal of our project is to design a stable, robust microbial community for the production of valuable compounds from lignocellulosic biomass. The metabolic processes are split between biomass-degrading bacteria and the production bacteria, which transforms the degradation products into valuable products. For the first part, we engineered Caulobacter displaying functional biomass-transforming enzymes that act on cellulose. For the second part, we engineered E.coli producing β-carotene as a proof of concept. Now we need to confirm that these two bacteria can be co-cultured together to generate a stable consortia for consolidated bioprocessing.

Check out other parts of our project below!