Team:Bordeaux/Model

Sleep with EpiC elegans



All iGEM projects work with modified organisms. When we work with those organisms, the question of confinement is essential to prevent their propogation out of the lab. Even if each team thinks about the best tool to answer this question, our team has decided to think about the worst situations.

What happen when a bacteria population escape from our tubes ?

To answer this question, we decided to create a model in order to see :

  • how many bacteria will be able to live on the lab bench
  • if the bacteria will be able to maintain their plasmid lost

To present our work, we will explain our model in different parts. First, we will explain what type of models we have chosen and why. Then, we will describe how we have created our model and explain its initialization. After, we will explain the equation that we have chosen to modeliz the bacteria growth and the plasmid lost. Finally, we will make an assessment of our model, explain how we have validated it and give our perspectives for this project.

1. The multi-agent model

The definition

In informatics, the muti-agent system aims to represent intelligent agents which interact between them in a specific environment. In our case, our agents are bacteria where are dispersed in a corner of the laboratory. They move, growth and are able to do cell division. Some of them have a recombinant plasmid which give them a antibiotic resistance. Our model helps us to know if our bacteria is able to survive on this specific environment and if they can maintain their plasmid in specific conditions.
This model is interesting to use because it modelizes how act the agents in the environment and how interact the environment with the agents.