Team:SCSU-New Haven

Southern Connecticut State University

Brainstorming

  • Chemical Synthesis
  • Improve a chemical synthesis for vitamin production

    Novel synthesis of costly drug

  • Project using a GC chassis
    • Mycobacterium smegmatis
    • Tuberculosis detection/treatment

    • Rhodococcus
    • Environmental remediation

  • Focus on CRISPR

Selection

After researching each topic and several rounds of discussion we decided to pursue a project involving Tuberculosis. Our team wanted to add more GC rich parts to the iGEM repository and a project focusing on Tuberculosis would allow us to do so while tackling a global problem.

Project Description

It has been shown that different diseases cause the production of volatile organic compounds (VOCs) in the body. This seems to be true of Tuberculosis especially due to its infection site being the lungs. We want to produce a Mycobacterium smegmatis based VOC sensor activated by Tuberculosis specific compounds.

Our goals

Our final product should be a simple breath test device that accurately reports infection within several hours and does not require a laboratory environment to use. It should be storable in non-refrigerated conditions and have a simple indicator most likely color change.