Difference between revisions of "Team:UESTC-software/Future"

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                 <p> Bio101 should not only be a kind of software created to join in the competition, but also a tool with an ultimate goal to contribute to the revolution of information storage technology. We have done our best to design, implement and test Bio101 which has successfully realized its functions of information archiving and rewriting. And we will pay further efforts to improve our software, mainly focus on two aspects: wet-lab verification of DNA editing and integration of DNA information storage system.</p>
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                 <p> Although Bio101 has fulfilled its design goals to encode and decode information in DNA sequences, there is a long way to put DNA information storage into practical usage. In the future, we will focus on two aspects to improve our software further, wet-lab verification of our DNA editing protocol and integration of Bio101 with hardware for on-site DNA synthesis and sequencing.</p>
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                 <h2 id="Wet-lab verification of DNA editing">Wet-lab verification of DNA editing</h2>
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                 <p>To prove the feasibility of data editing function, we plan to do a wet-lab validation of DNA editing. We have used our software to design the crRNA and the new DNA fragment according to user demand. Since we need CRISPR-Cas9 system to damage DNA which corresponds to the target file, it’s necessary to validate the feasibility in bio-technology. Our first goal is to design a workable experiment of knockout.</p>
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                 <p>To prove the feasibility of data editing protocol, we plan to do a wet-lab validation. The editing function Bio101 provides a BioBrick part for the small-guide RNA (sgRNA) expression and we will test its efficiency and accuracy working together with CRISPR/CAS9 system to erase the DNA fragments which encoding the old data to be replace. </p>
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                 <p class="img-p" style="font-size: 13px;"><img src=""/><br/><B>Fig.1.</B>Wet-lab verification of DNA editing.</p>
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                 <p class="img-p" style="font-size: 13px;"><img src="https://static.igem.org/mediawiki/2016/f/fd/UESTC-Software-future-1.png"/><br/><B>Fig.1.</B>Wet-lab verification of DNA editing.</p>
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                 <h2 id="Integration of DNA information storage system">Integration of DNA information storage system</h2>
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                 <p>Bio101 now has solved the problems in software, but still can’t solve the challenges in hardware. In order to provide friendlier user experience, we want to realize the integration of coding, synthesis, decoding and editing, which means you can use DNA information storage system as convenient as USB. </p>
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                 <p>Currently, Bio101 provides a solution to the IT part of the DNA information storage system. For practical usage, we need to integrate both the IT part and BT part, including coding, synthesis, sequencing, decoding and editing, into one system. The latest development of in the areas of DNA synthesis and sequencing and lab-on-chip provides us possibility. We will investigate some possible integration ideas in the future.  </p>
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                 <p class="img-p" style="font-size: 13px;"><img src=""/><br/><B>Fig.2.</B>Integration of DNA information storage system </p>
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                 <p class="img-p" style="font-size: 13px;"><img src="https://static.igem.org/mediawiki/2016/7/7e/UESTC-Software-future-2.png"/><br/><B>Fig.2.</B>Integration of DNA information storage system. </p>
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                <p>In the era of information explosion, there is no doubt that Bio101 will have a bright future. Once the current biotechnology achieves a breakthrough in DNA synthesis and sequencing, our system could be widely used everywhere. </p>
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Revision as of 07:36, 19 October 2016

三级页面

Future

Although Bio101 has fulfilled its design goals to encode and decode information in DNA sequences, there is a long way to put DNA information storage into practical usage. In the future, we will focus on two aspects to improve our software further, wet-lab verification of our DNA editing protocol and integration of Bio101 with hardware for on-site DNA synthesis and sequencing.

DNA Editing

To prove the feasibility of data editing protocol, we plan to do a wet-lab validation. The editing function Bio101 provides a BioBrick part for the small-guide RNA (sgRNA) expression and we will test its efficiency and accuracy working together with CRISPR/CAS9 system to erase the DNA fragments which encoding the old data to be replace.


Fig.1.Wet-lab verification of DNA editing.

System Integration

Currently, Bio101 provides a solution to the IT part of the DNA information storage system. For practical usage, we need to integrate both the IT part and BT part, including coding, synthesis, sequencing, decoding and editing, into one system. The latest development of in the areas of DNA synthesis and sequencing and lab-on-chip provides us possibility. We will investigate some possible integration ideas in the future.


Fig.2.Integration of DNA information storage system.

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