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Revision as of 09:01, 30 September 2016

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 Background 

Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapy to treat several diseases. Up to now, MSCs are used in over 600 ongoing clinical trials (June, 2016) like treating IBD, diabetes, encephalitis, etc. MSCs in current clinical use are isolated from bone marrow, adipose tissue and the umbilical cord. Different from the embryonic stem cells, MSCs have been shown to be highly immunosuppressive. In many studies, MSCs were found to suppress adaptive immune system as well as inherent immune system in multiple inflammatory diseases, which make MSCs a promising tool in treating inflammatory disease.

Despite significant advantages, clinical trials of MSCs have produced mixed results which may significantly impede the advancement of MSC-based therapies. One of the most important reasons is for the inefficient homing ability of MSC that only a few MSC can indeed arrived the inflamed tissue after systematic administration and exert their immunomodulatory function.

Current Design

This summer, next generation of MSCs are coming. We intend to construct a circuit of three plasmids that will be able to reinforce the locating function of MSCs. Previous studies have demonstrated that immune cells depend on chemokine receptors to accomplish directional moving. In our project, we are going to empower MSCs with chemokine receptors in order to ensure its effective homing. At the same time, with the purpose of locating in vivo MSC and assuring their arrival at the inflamed tissue, we will introduce several kinds of positioning system into our system and detect them by various methods.

Before you start:

Please read the following pages:

Styling your wiki

You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.

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Wiki template information

We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!

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Inspiration

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