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<br> exchange of ideas and even hot debates, we inspire and illuminate each other, with pure | <br> exchange of ideas and even hot debates, we inspire and illuminate each other, with pure | ||
<br> curiosity for science. | <br> curiosity for science. | ||
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+ | <h2 class="contentPage">The voice within</h2> | ||
+ | A priceless tradition for the Tsinghua iGEM community is that once you have become an iGEMer, | ||
+ | <br> you are integrated into a welcoming community, within which crazy ideas are freely allowed | ||
+ | <br> and team members are uncontionally supported. We therefore started the Human Practice section | ||
+ | <br> by incorporating voices from previous iGEM members from Tsinghua University, and named it "The | ||
+ | <br> Voice Within", because we genuinely believe their opinions are truly reflective of who we are. | ||
+ | <br> Views below were collected from three iGEM team members in the past. We truly appreciate their | ||
+ | <br> insightful input. | ||
+ | <br> | ||
+ | <br>"Detrimental gene mutation leading to cancer has been a problem that perplex human for a long time, | ||
+ | <br> and still not solved yet. While cancer immunotherapy become hotspot and achieved a lot of progress | ||
+ | <br> recent years, there are many restrictions in this field to deal with the solid tumor. So I was really | ||
+ | <br> interested in iGEM 2016 Tsinghua’s project when I knew that they wanted to design such a surveillance | ||
+ | <br> system. It can, to some degree, cut off the road from gene mutation to cancer. I consider it a quite | ||
+ | <br> innovative idea and feel hopeful that they decided to utilize the dCas9 as a core tool to manipulate it. | ||
+ | <br> With the advances in dCas9 function and manipulation, this surveillance system can be realized in cancer | ||
+ | <br> precaution with advantages like low-cost, effective, precisely controlled and convenient. | ||
+ | <br> | ||
+ | <br>As a member of iGEM 2015 Tsinghua team, I feel glad to see that this team has become more mature in the | ||
+ | <br>way of thinking and realizing their projects. Even though they went through several obstacles, they work | ||
+ | <br> together and solve them together, which made the whole team grow together. I wish you a good luck, iGEM | ||
+ | <br> 2016 Tsinghua team!", Xiong Sihan, Team Tsinghua 2015. | ||
+ | <br> | ||
+ | <br>"Finding ways to surveil and respond to genetic mutations is one of the most pivotal mission for all living | ||
+ | <br> creatures along the river of evolution, also for scientists today, who have been sparing no effort in | ||
+ | <br> seeking ways to prevent and treat cancer. In addressing this challenging question, Tsinghua Team raised a | ||
+ | <br> pioneering idea of using a RNA-targeting CRISPR/Cas9 system to detect critical genetic mutations and induce | ||
+ | <br> the suicide of the mutated cells. Creating Cas9 protein with GAL4 binding ability and precise discrimination | ||
+ | <br> of normal and mutated genes are two highlights of the project. Delicate control of the whole system is | ||
+ | <br> never easy, however, Tsinghua Team has successfully proved the concept in baking yeast. The next goal may | ||
+ | <br> be mammalian systems. From my perspectives, techniques like the suvCas9 have great potential in next | ||
+ | <br> generation of cancer therapy because they could work together with the hosts’ immune system to prevent | ||
+ | <br> malignancy at the first line.", Liu Yue, Team Tsinghua 2014. | ||
+ | <br> | ||
+ | <br>"Congratulations that you have done a really cool job! I am fascinated by what you have brought to the iGEM | ||
+ | <br> society. Surveillance is a rather important idea, that you're treating a cellular system, or your genetic | ||
+ | <br> machine, less like a pool of interactions but more like a sophisticated and well-functioning system, with | ||
+ | <br> top-down self regulation. This, I believe, will be one of the foundations for future genetic machines, and | ||
+ | <br> your delecate work will provide huge help for future iGEMers and researchers. Look so much forward to your | ||
+ | <br> presentation this year!", Wang Jiawei, Team Tsinghua 2015. | ||
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Latest revision as of 02:08, 20 October 2016