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| − | <!DOCTYPE html>
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| − | <html lang="en" dir="ltr" class="client-nojs">
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| − | <head>
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| − | <meta charset="UTF-8" />
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| − | <title>Team:Warwick-2016.igem.org</title>
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| − |
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| − | <head>
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| − |
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| − | <style type="text/css">
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| − |
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| − | #text {margin-top: 50px; z-index: 9999;}
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| − | #text h2 {font-size: 25px; text-decoration: none; border-bottom: 0px; display: block; background-color: #c97062; color: #fff; font-weight: bold; border-radius: 4px; padding: 15px; opacity: 0.5; }
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| − |
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| − | .blockk:hover h2 {opacity: 0.9 !important; transition-property: opacity;
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| − | transition-duration: 1s;
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| − | transition-timing-function: ease; }
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| − |
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| − | #text h4 {text-decoration: none; font-size: 14px; font-weight: normal !important; border-bottom: 0px; display: block; padding-left: 5px; padding-top: 5px; padding-bottom: 5px; line-height: 2; text-align: justify; color: #272a2b}
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| − |
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| − |
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| − |
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| − |
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| − | /*references*/
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| − | .content .tooltip {
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| − | background-color: #fff;
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| − | border: 1px #22343C solid;
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| − | border-radius: 4px;
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| − | padding: 3px;
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| − | position: absolute;
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| − | width: 300px;
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| − | z-Index: 99999;
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| − | display: none;
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| − | letter-spacing: 1px;
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| − | line-height: 1;
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| − | font-size: 11px;
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| − | }
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| − |
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| − | .tooltip a {color: #22343C;}
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| − | .tooltip {color: #22343C;}
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| − |
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| − | .content {
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| − | position: relative;
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| − | }
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| − |
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| − | .content {color: #d67166;}
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| − |
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| − | /* end-of-references */
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| − |
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| − | .bigtitle {width: 42%; margin-top: 100px; margin: 0 auto; font-size: 16px; background-image:none /*url('https://static.igem.org/mediawiki/2015/4/43/Warwick_headercircle.png')*/; text-align: center; line-height: 2;
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| − | background-position: top center; background-repeat: no-repeat; background-size: contain; padding: 9%; position: relative; margin-bottom: 100px; color: #22343C;}
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| − |
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| − | .bigtitle a {color: #22343C; text-decoration: none;}
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| − |
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| − | .title2 {font-family: Satisfy; font-size: 380%; text-align:center;}
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| − |
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| − | .titlecircle {width: 85%; margin: 0 auto; padding-top: 12%;}
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| − |
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| − | .arrow {font-size: 50px;}
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| − |
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| − |
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| − | #text h2 {
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| − | font-size: 25px !important;
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| − | text-decoration: none;
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| − | border-bottom: 0px;
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| − | display: block;
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| − | background-color: #c97062;
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| − | color: #fff;
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| − | font-weight: bold;
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| − | border-radius: 4px;
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| − | padding: 10px;
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| − | opacity: 0.5;
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| − | line-height: 1.4;
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| − | }
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| − |
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| − | a {
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| − | color:#473E4F;
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| − | -webkit-transition: color ease-in-out 300ms;
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| − | }
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| − |
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| − | a:hover
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| − | {color: #70C4BB;
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| − | text-decoration:none;
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| − | -webkit-transition: color ease-in-out 300ms;
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| − | }
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| − |
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| − |
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| − |
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| − | a:visited {
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| − | color:#473E4F;
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| − | text-decoration:none;
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| − | -webkit-transition: color ease-in-out 300ms;
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| − | }
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| − |
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| − | #bodyContent {
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| − | background-color:#F8FFFF;
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| − | }
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| − |
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| − | @media (max-width:400px){
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| − | p {text-align:justify;};
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| − | h3 {font-size:10px;};
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| − | }
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| − |
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| − | /* wiki width fixing */
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| − | #contentSub, #search-controls, .firstHeading, #footer-box, #catlinks, #p-logo {
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| − | display:none;}
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| − | #top-section {
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| − | border: none;
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| − | height: 0px;}
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| − |
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| − | #p-logo, h1.firstHeading,#search-controls,#catlinks {display:none;}
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| − | #footer #f-list {margin-top:0;}
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| − | #top-section,#footer-box{margin:0;padding:0;width:100%;height:0;}
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| − | #contentSub {margin: 0;}
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| − |
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| − | #globalWrapper, #content {
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| − | width: 100% !important;
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| − | height: 100%;
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| − | border: 0;
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| − | background-color: F8FFFF;
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| − | margin: 0;
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| − | padding: 0 !important;
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| − | padding-bottom: 0 !important;
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| − | top:0;
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| − | line-height: 1;
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| − | position: absolute;
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| − | }
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| − |
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| − | #bodyContent {top: 0px;
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| − | position: absolute;
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| − | height: auto;
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| − | min-height: 100%;
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| − | margin: 0 auto;
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| − | padding: 0;
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| − | overflow-y: scroll;
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| − | overflow-x: hidden;
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| − | margin-left:-500px ;}
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| − |
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| − | html, body, #container {
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| − | top: 0px;
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| − | width:100%;
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| − | height: auto;
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| − | overflow-x: hidden;
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| − | background: none !important;
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| − | }
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| − |
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| − | .buttonblack {
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| − |
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| − | margin-bottom: 10px;
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| − | margin-top: 10px;
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| − |
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| − | }
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| − |
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| − |
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| − | .intro-buttons {
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| − | padding-top: 20px; color: #FFFFFF;
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| − | }
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| − |
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| − |
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| − |
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| − | .intro-buttons a { color: #FFFFFF; text-decoration: none;}
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| − |
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| − |
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| − |
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| − |
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| − | #header2:before
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| − | {
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| − | content: "";
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| − |
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| − |
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| − | position: fixed;
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| − | top: 0;
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| − | left: 0;
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| − | bottom: 0;
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| − | margin: 0;
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| − | padding: 0;
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| − | width: 100%;
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| − | height: 100%;
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| − | overflow: hidden;
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| − | display: block;
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| − | border: none;
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| − |
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| − | }
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| − |
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| − |
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| − |
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| − |
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| − |
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| − | .back {text-align: center; top: 15%; position: relative;}
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| − | .back img {padding-left: 10px; padding-right: 10px; padding-bottom: 7px;}
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| − | .back a {color: #2a2133; font-size: 16px; font-family: Raleway; letter-spacing: 1.5px; }
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| − | .back a:hover {color: #493c54; -webkit-transition: color ease-in-out 400ms;}
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| − |
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| − |
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| − |
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| − |
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| − |
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| − |
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| − | @media screen and (max-width: 960px) {
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| − | #abstracttext p { line-height: 2; font-size: 13px; text-indent: 50px;
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| − | }
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| − |
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| − |
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| − | }
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| − |
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| − | #abstract h2 {font-size: 20px;}
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| − |
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| − |
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| − |
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| − |
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| − |
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| − | .mailus {background: #F0F0F5; padding: 5px;}
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| − |
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| − | /*menu*/
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| − |
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| − | .mainmenu {
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| − | position: fixed;
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| − | top: 0;
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| − | left: 0;
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| − | z-index: 99999;
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| − | width: 100%;
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| − | height: 100px;
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| − | font-size: 20px;
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| − | background-color: #fff;
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| − | box-shadow: 0px -6px 22px;
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| − | }
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| − |
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| − |
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| − |
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| − | #hidden-menu {
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| − | margin-left:85%;
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| − | display: none;}
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| − |
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| − | #hidden-menu:hover ul{
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| − | height:auto;
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| − | width:auto;
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| − | z-index:99999999;
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| − | display: block;
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| − | }
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| − |
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| − | #hidden-menu ul li {
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| − | background-color: #70C4BB;
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| − | text-align: center;
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| − | display: block;
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| − | margin:none;
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| − | padding-left:20px;
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| − | padding-right:20px;
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| − | padding-top:8px;
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| − | padding-bottom:8px;
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| − | box-shadow:1.5px 1.5px lightgrey;
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| − | border-radius:4px;
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| − | opacity:0.9;
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| − | z-index:99999999;
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| − | }
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| − |
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| − | #hidden-menu ul {
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| − | position:fixed;
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| − | padding-top:60px;
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| − | right: 0px;
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| − | padding-right: 50px;
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| − | display: none;
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| − | }
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| − |
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| − | #hidden-menu ul li a {
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| − | color: #fff; font-size: 23px;
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| − | }
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| − |
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| − | #hidden-menu ul li a:hover {
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| − | color: #787172
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| − | }
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| − |
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| − | #hidden-menu a {
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| − | color: #473E4F; text-decoration: none; font-family: Raleway;
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| − | }
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| − |
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| − | #hidden-menu a:hover {color: #70C4BB;
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| − | -webkit-transition: color ease-in-out 150ms;
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| − | }
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| − |
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| − |
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| − | #mobilebutton {
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| − | height:50px;
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| − | width:50px;
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| − | top:0;
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| − | right:0px;
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| − | margin-top: 17px;
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| − | position:fixed;
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| − | opacity:0.9;
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| − | z-index:999999999;
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| − | }
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| − |
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| − |
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| − | #igemlogo {
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| − | position:fixed;
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| − | top:30px;
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| − | left: 10px; float:left;
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| − | z-index:99999;
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| − | }
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| − |
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| − | .menu-items {display: inline-block;
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| − | width: 100%;
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| − | text-align: right;
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| − | position:fixed;
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| − | top: 20px;
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| − | z-index:99998;
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| − | right: 0;
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| − | padding-right: 53px;
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| − | }
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| − |
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| − |
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| − |
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| − | .menu-items li {
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| − | display: inline-block;
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| − | margin-right: 20px;
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| − | margin-left: 10px;
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| − | margin-top: 0px;
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| − | letter-spacing: 3px;
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| − | height: 30px;
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| − | text-transform: uppercase;
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| − | font-size: 12px;
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| − | font-weight: bold;
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| − | }
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| − |
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| − |
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| − | .menu-items li:hover ul, .menu-items li.hover ul{
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| − | padding-left: 0;
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| − | visibility: visible;
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| − | opacity: 1;
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| − | transition: opacity 1s ease-in 0s, visibility 0s linear 0s;
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| − | }
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| − |
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| − |
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| − |
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| − |
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| − | .menu-items li ul {
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| − | visibility: hidden;
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| − | opacity: 0;
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| − | transition: opacity 0.5s ease-in 0s, visibility 0s linear 0.5s;
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| − | position: absolute;
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| − | top: 10px;
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| − | margin-right: 0px;
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| − | margin-left: 0px;
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| − | padding: 0;
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| − | text-align: left;
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| − | }
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| − |
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| − | .menu-items li ul a{list-style-type:none;}
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| − |
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| − |
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| − | .menu-items li ul li{
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| − | text-align: left;
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| − | padding: 2px 0px;
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| − | width: auto;
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| − | display:block;
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| − | height: 8px;
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| − | margin: 0px;
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| − |
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| − | }
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| − |
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| − | .menu-items li ul li a {
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| − | color: #22343C;
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| − | font-size: 9px;
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| − | }
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| − |
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| − | .menu-items li ul li a:hover {
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| − | color: #FE6C68;
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| − | }
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| − |
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| − | .menu-items a {
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| − | color: #22343C;
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| − | text-decoration: none;
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| − | font-family: Raleway;
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| − | }
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| − |
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| − | .menu-items a:hover {color: #70C4BB;
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| − | -webkit-transition: color ease-in-out 150ms;
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| − | }
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| − |
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| − |
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| − |
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| − |
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| − | .buttonblack {
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| − | margin-bottom: 10px;
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| − | margin-top: 10px;
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| − | text-transform: uppercase;
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| − | font-size: 14px;
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| − | font-weight: normal;
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| − | line-height: 1.428571429;
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| − | text-align: center;
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| − | white-space: nowrap;
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| − | vertical-align: middle;
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| − | border-radius: 4px;
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| − | transition-property: background-color, color, border-color;
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| − | transition-duration: 1s;
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| − | transition-timing-function: ease;
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| − | color: #FFFFFF;
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| − | border: solid 5px #336666;
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| − | padding: 10px 16px;
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| − | text-decoration: none;
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| − | width:180px; background-color: #336666;
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| − | font-family: Raleway;
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| − | letter-spacing: 2px;
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| − | font-weight: bold;}
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| − |
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| − |
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| − | .buttonblack:hover {border-color: #fff; color: #fff; background: none;}
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| − | .buttongreen:hover {border-color: #019966; color: #019966; background: none;}
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| − |
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| − | .buttongreen { margin-bottom: 10px;
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| − | margin-top: 20px;
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| − | text-transform: uppercase;
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| − | font-size: 14px;
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| − | font-weight: normal;
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| − | line-height: 1.428571429;
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| − | text-align: center;
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| − | white-space: nowrap;
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| − | vertical-align: middle;
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| − | border-radius: 4px;
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| − | transition-property: background-color, color, border-color;
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| − | transition-duration: 1s;
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| − | transition-timing-function: ease;
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| − | color: #FFFFFF;
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| − | border: solid 5px #019966;
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| − | padding: 10px 16px;
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| − | text-decoration: none;
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| − | width:180px; background-color: #019966;
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| − | font-family: Raleway;
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| − | letter-spacing: 2px;
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| − | font-weight: bold;}
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| − |
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| − | a.buttongreen {text-decoration: none; color: #fff;}
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| − |
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| − | .igemlogoo {width: 65px;}
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| − |
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| − |
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| − | /*media*/
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| − |
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| − | @media(max-width:1280px){
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| − | .menu-items {padding-right: 53px;}
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| − | .menu-items li {margin-right: 12px; margin-left: 12px; letter-spacing: 3px;}
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| − |
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| − |
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| − | }
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| − |
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| − |
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| − | @media(max-width:1152px){
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| − | .menu-items li {margin-right: 12px; margin-left: 9px; letter-spacing: 2.8px;}
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| − |
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| − | }
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| − |
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| − |
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| − | @media(max-width:1024px){
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| − | .menu-items li {
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| − | margin-right: 9px;
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| − | letter-spacing: 2.4px; }
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| − | .menu-items ul li ul a {font-size: 10px; letter-spacing: 1.9px;}
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| − | .igemlogoo {width: 50px;}
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| − | #bodyContent {margin-left: -60px; width: calc(100% + 32px);}
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| − |
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| − | }
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| − |
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| − | @media(max-width:960px){
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| − | .menu-items li {
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| − | margin-right: 9px;
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| − | font-size: 10px;
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| − | letter-spacing: 2.4px;
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| − | }
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| − |
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| − | .menu-items ul li ul a {font-size: 9px; letter-spacing: 1.9px;}
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| − |
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| − |
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| − | }
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| − |
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| − |
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| − | @media(max-width:900px){
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| − |
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| − |
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| − |
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| − | .menu-items li {
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| − | margin-right: 9px;
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| − | margin-left: 0px;
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| − | font-size: 10px;
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| − | letter-spacing: 2.4px;
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| − |
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| − | }
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| − |
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| − | .menu-items ul li ul a {font-size: 9px; letter-spacing: 1.9px;}
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| − |
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| − | .menu-items li ul li {height: 6px;}
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| − |
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| − | .mainmenu {height: 90px; }
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| − |
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| − |
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| − | .menu-items li ul {top: 20px;}
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| − |
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| − | }
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| − |
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| − |
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| − |
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| − |
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| − |
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| − | @media(max-width:830px){
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| − |
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| − | .igemlogoo {width: 40px; opacity: 0.7;}
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| − |
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| − | #igemlogo {top: 40px; z-index: -1;}
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| − | #Warwickigemlogo {display: none;}
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| − |
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| − | .menu-items ul li ul a {letter-spacing: 1.4px;}
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| − |
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| − |
| |
| − | }
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| − |
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| − |
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| − | @media(max-width: 768px){
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| − |
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| − |
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| − | .menu-items li {
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| − | letter-spacing: 2px;
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| − | font-size: 10px;
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| − | margin-right: 3px;
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| − | margin-left: 3px;
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| − | margin-top: 6px;
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| − | text-align: center;
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| − | }
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| − | .menu-items ul {text-align: center; padding: 0; margin: 0 2px; list-style:none;}
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| − |
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| − | .menu-items {text-align: center; padding-left: 0px; margin: 0 auto;}
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| − | .menu-items li ul {position: absolute; left: 0; width: 100%; text-align: center; margin-top: 20px; }
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| − |
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| − | .menu-items li ul li {display: inline-block; margin-left: 10px; margin-right: 10px; height: 34px; }
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| − | .menu-items ul li ul a { font-size: 10px; letter-spacing: 2px;}
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| − |
| |
| − | }
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| − |
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| − |
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| − |
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| − | @media(max-width: 740px){
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| − |
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| − | .menu-items li {
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| − | letter-spacing: 1.6px;
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| − | font-size: 10px;
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| − | margin-right: 3px;
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| − | <body> | + | <head> |
| | + | <title>iGEM Warwick 2016 - Home</title> |
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| | + | <a href="https://2016.igem.org/Team:Warwick">Home</a> |
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| | + | <a href="https://2016.igem.org/Team:Warwick/Description">Project</a> |
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| | + | <a href="https://2016.igem.org/Team:Warwick/Description">Description</a> |
| | + | <a href="https://2016.igem.org/Team:Warwick/Design">Design</a> |
| | + | <a href="https://2016.igem.org/Team:Warwick/Parts">Parts</a> |
| | + | <a href="https://2016.igem.org/Team:Warwick/Model">Model</a> |
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| | + | </div> |
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| | + | <a href="https://2016.igem.org/Team:Warwick/Attributions">Attributions</a> |
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| | + | <a href="https://2016.igem.org/Team:Warwick/Human_Practices">Summary</a> |
| | + | <a href="https://2016.igem.org/Team:Warwick/HP/Silver">Silver</a> |
| | + | <a href="https://2016.igem.org/Team:Warwick/HP/Gold">Gold</a> |
| | + | <a href="https://2016.igem.org/Team:Warwick/Integrated_Practices">Integrated Practices</a> |
| | + | <a href="https://2016.igem.org/Team:Warwick/Education">Education</a> |
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| − | </div> | + | <h1>Warwick iGEM 2016</h1> |
| | + | <p>Application of CRISPR/Cas9 as a novel modular biosensor</p> |
| | + | </section> |
| | | | |
| − |
| + | <!-- One --> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Description">Project</a>
| + | <section id="one" class="wrapper"> |
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| + | <div class="flex flex-3"> |
| − | | + | <article> |
| − | | + | <header> |
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| + | <h3>CRISPR/Cas9<br /> Biosensor.</h3> |
| − | <li><a href="#">Lab work</a> | + | </header> |
| − | <ul> | + | <p>Using a dCas9 protein and an RNA-binding protein (RBP) fused to an effector, transcription of a fluorescent reporter gene can be regulated, with a significant colour change indicating the presence of targeted RNA.</p> |
| − | | + | </article> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Experiments"> ● Experiments & Protocols</a></li> | + | <article> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Sensors"> ● Lab book</a></li> | + | <header> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Safety"> ● Biosafety</a></li> | + | <h3>Leptospirosis Impact and Diagnosis.</h3> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Design"> ● Problems Encountered</a></li> | + | </header> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Fermentation"> ● Trouble-shooting</a></li> | + | <p>Our project will enable diagnosis of the disease at an early stage, increasing the likelihood of successful treatment and reducing the risk of irreversible bodily damage.</p> |
| − | | + | </article> |
| − | | + | <article> |
| − | </ul>
| + | <header> |
| − | </li>
| + | <h3>Pollutant Detection: Heavy Metal Ions.</h3> |
| − |
| + | </header> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/HumanAspects">Human Aspects</a>
| + | <p>Our team has developed a system capable of detecting these ions in water sources, potentially improving the quality of human life on a global scale, in an inexpensive easily accessible manner.</p> |
| − |
| + | </article> |
| − | </li>
| + | </div> |
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| + | </div> |
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Teamintroduction">Team Introduction</a></li> | + | <div class="flex"> |
| − | | + | <div class="copyright"> |
| − | | + | © Warwick iGEM 2016. |
| − | <li><a href="#">Process</a><ul> | + | <ul class="icons"> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Interlabstudy"> ● InterLab Study</a></li>
| + | <li><a href="https:// www. facebook. com/ WarwickIGEM" class="logo" >< img src="https:// static.igem.org/ mediawiki/ 2016/ 6/ 6f/ T--Warwick--Facebook.png" alt=" Facebook" class=" logo"> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Collaborations"> ● Collaborations</a></li> | + | </a></li> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Notebook"> ● Notebook</a></li> | + | <li><a href="https:// twitter. com/ warwickigem" class="logo" >< img src="https:// static.igem.org/ mediawiki/ 2016/ 7/ 7e/ T--Warwick--Twitter. png" alt="Twitter" class="logo"> |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Modelling"> ● Modelling</a></li>
| + | </a></li> |
| − | | + | </ul> |
| − | | + | <p>We thankfully acknowledge generous funding support from our sponsors below.</p> |
| − | </ul>
| + | <a href="https://2016.igem.org/Team:Warwick/ Attributions" class=" logo" > |
| − | </li>
| + | <img src="https://static.igem.org/mediawiki/2016/f/f6/T--Warwick--banner.png" alt="IGEM WARWICK" class="bannertop"> |
| − | | + | </a> |
| − | <li><a href="#">Outcomes</a><ul>
| + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Software">● Software</a></li>
| + | |
| − | <li><a href="https:// 2016. igem.org/ Team:Warwick/Bactoman"> ● Public engagemnt< /a></li> | + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Parts"> ● Parts</a></li>
| + | |
| − | | + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Achievements"> ● Achievements</a></li>
| + | |
| − | | + | |
| − | </ul></li>
| + | |
| − | | + | |
| − | | + | |
| − | <li><a href="#">People</a> | + | |
| − | <ul>
| + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/ Education" > ● Education</a></li> | + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Sponsors">● Sponsors</a></li>
| + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Attributions">● Attributions</a></li>
| + | |
| − | </ul>
| + | |
| − | </li>
| + | |
| − | | + | |
| − | </ul>
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| − | | + | |
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| − | </div>
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| − | </nav>
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| − | <li><a href="https://2016.igem.org/Team:Warwick">Home</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Description">Project</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Effectors">Effectors</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Sensors">Sensors</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Design">Gut-on-a-Chip</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/HumanAspects">Human Aspects</a> | + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Entrepreneurship">Entrepreneurship</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Software">Software</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Collaborations">Collaborations</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Parts">Parts</a></li>
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| − | | + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Achievements">Achievements</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Team">Team</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Warwick/Attributions">Attributions</a></li>
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| − | | + | |
| − | <li><a href="https://2016.igem.org/Team:Warwick/Interlabstudy">InterLab Study</a></li>
| + | |
| − | <head>
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| − | <br><br><img src="http://s2.quickmeme.com/img/1a/1af33bbe837b9b1d65c9ac632afc856f90796618695ce6561dfb09387fefac18.jpg" alt="Under Construction">
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| − | <h1 style="color:Black;"> Project Description</h1>
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| − | | + | |
| − | <p style="font-family: Geneva, Tahoma, Verdana, sans-serif">
| + | |
| − | There is no global challenge worth greater investment than improving quality of life. During initial discussions, we identified a wide range of problems that we felt further scientific development would be most beneficial: increasing crop yields; sewage filtration; reclamation of rare earth metals. Upon evaluation, the team decided that synthesizing a modular biosensor detection kit would be most influential, due to the potential application to a wide range of diseases and environmental health issues. This affordable, accessible system could tackle multiple issues over a large demographic, making the venture truly worthwhile. Lyme’s disease, although not at the forefront of discussion, is the inceptive focus of the investigation, as current detection methods can only be applied after debilitating symptoms have manifested. Our novel biosensor would therefore allow treatment of the disease at a period before serious symptoms have arisen. The theoretically adaptable nature of the bio detector also could allow replacement of antibody-reliant detection systems, hence why our other primary research focus is leptospirosis. We also aim to modify this technology such that it can be used to monitor toxic lead and mercury levels in water supplies.
| + | |
| − | | + | |
| − | <br><br>Our detection system for infectious agents and environmental pollutants will be based on CRISPR/Cas9 technology, relying on conformational changes in an RNA-based sensor that will trigger transcriptional regulation by a dCas9 protein. We plan to produce a modular gene circuit that can detect the presence of either RNA from an infectious agent or metallic ion and output a fluorescent signal. This will be arranged on a plasmid encoding for an RNA sensor, the CRISPR/Cas9 system, and a fluorescent reporter. The RNA sensor will be a modified sgRNA containing a motif binding either Borrelia/Leptospira RNA or lead/mercury aptamers. This binding will cause a conformational change such that the modified dCas9 enzyme may bind upstream of the transcriptional start site of the fluorescent reporter gene inducing transcription. We will be testing this using multiple novel dCas9 fusion proteins as well as more traditional CRISPR/dCas9 methods. Afterwards, the sensor will be freeze-dried onto a paper scaffold for ease of use.
| + | |
| − | | + | |
| − | <br><br>An example of a modified CRISPR/dCas9 system to be used in the project.
| + | |
| − | By the end of the project we hope to create a paper based sensor that will be able to be used in a low-tech, out-of-lab, environment. We hope this will make it available to less economically developed countries as a frontline diagnostic tool and make a real impact in the fight against infectious diseases and pollution.</p>
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| − | <h1 style="color:Black;">Contact Us</h1>
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| − | <body>
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| − | Facebook <a href="https://www.facebook.com/WarwickIGEM/">
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| − | <img border="0" alt="Facebook" src="https://static.igem.org/mediawiki/2016/4/41/Facebook_Link_Badge_Black.png" width="20" height="20">
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