Difference between revisions of "Team:Tianjin/Model"
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<h1 id="about" class="title text-center"><span>Heterogenous Degradation By PETase</span></h1> | <h1 id="about" class="title text-center"><span>Heterogenous Degradation By PETase</span></h1> | ||
<h2><b>Model Overview</b></h2> | <h2><b>Model Overview</b></h2> | ||
| − | <p style="font-size:18px" id=" | + | <p style="font-size:18px" id="Overview">In our experiment we use engineered bacteria as machines to secrete PETase to degrade PET.At first the bacteria secrete PETase ,and then enzymes diffuse into liquid phase body from the cell surface ,from liquid to the surface of PET successively.PETase adsorbs on PET during which process the substrate binding sites of PETase contact with the surface.Finally PETase finds catalytic sites on plastics and combine them with its active center.Ester bonds are broken and chains in PET are ruptured,resulting in the degradation of PET.</p> |
<hr> | <hr> | ||
<h2><b>Assumptions</b></h2> | <h2><b>Assumptions</b></h2> | ||
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| + | <div class="assumptions"> | ||
| + | <p>1.There exists feedback inhibition regulation in the growing process of a single bacteria. Unlimited growth of population growth can’t be supported due to the limitation of space and resources in a certain environment. When the population of individual bacterium has too much increased, the environment degrades and the average resource share declines, resulting in reduction in birth rate while mortality rate is increasing. Consequently it is reasonable to assume that there exists feedback inhibition regulation due to the influence of environmental factors.</p> | ||
| + | <p>2.A cell can be roughly considered as a sphere.</p> | ||
| + | <p>3.Enzymes are in the dynamic equilibrium when transferring in the liquid phase.</p> | ||
| + | <p>4.The resistance of enzymes’ spread from liquid body to the surface of PET is much larger than that of from the cells’ surroundings to liquid body.</p> | ||
| + | <p>5.It takes several steps for the enzymes to complete the degradation of PET. Enzymes have the substrate binding sites and active centers. We assume that the enzymes are firstly combined with the polymer substrate through their own substrate binding sites, and then the active centers catalyzed the degradation of the polymers.</p> | ||
| + | <p>The mass transfer of enzymes in the liquid phase will cause some of them to stay in the liquid body and the delay of enzyme concentration changes on the PET surface.</p> | ||
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Revision as of 01:38, 18 October 2016
