Difference between revisions of "Team:SVCE CHENNAI/Entrepreneurship"

 
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<h1>Entrepreunership</h1>
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<h2>Business Model Canvas</h2>
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<h2>Entrepreneurship</h2>
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In previous years, iGEM had an entrepreneurship track. Teams were encouraged to build projects and focus around commercializing their work. We have now moved to an award as the best work in this area may come from teams who are not solely focused on entrepreneurship.  
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Having interacted with Paskey diary farms and Vijaya milk industries earlier , and modifying our project such that AMPs were produced upon being added to milk by placing them under the regulation of a lac operon, so that on an industrial scale our system could be used to prolong the shelf life of milk, and presenting our business model to them we were awarded Rs.20000 by Paskey farms and 15000 by Vijaya milk industries.
 
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<p>The Best Supporting Entrepreneurship award recognizes exceptional effort to build a business case and commercialize an iGEM project. This award is open to all teams to show that entrepreneurship is something all teams can aspire to do with their project. This award can go to an new project, or to a previous project that a team aimed to commercialize. Have you filed a provisional patent on your project/device/process? Have you raised money to build and ship products? Have you pitched your idea to investors and received money? Complete the entrepreneurship section on the 2016 Judging form and tell us what you did. As always in iGEM, the aim is to impress the judges! </p>
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<h5>Inspiration</h5>
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<p>You can look at what other teams did to get some inspiration! <br />
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As you might have seen before, the Lactoshield consists of two membranes, an inner and an outer membrane.We initially selected PVC as the material for the inner membrane.
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Here are a few examples:</p>
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<li><a href="https://2014.igem.org/Team:UCC_Ireland">2014 UCC Ireland</a></li>
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<li><a href="https://2014.igem.org/Team:Imperial">2014 Imperial College London</a></li>
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<li><a href="https://2013.igem.org/Team:UCL_E">2013 University College London Entrepreneurship</a></li>
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<li><a href="https://2012e.igem.org/wiki/index.php/Team:MIT_E">2012 MIT Entrepreneurship</a></li>
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The properties of PVC that we found desirable were:
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    <li><span><i class="fa fa-caret-right" aria-hidden="true"></i></span>&nbsp;&nbsp; Low cost. </li>
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    <li><span><i class="fa fa-caret-right" aria-hidden="true"></i></span>&nbsp;&nbsp; Easily breakable. </li>
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    <li><span><i class="fa fa-caret-right" aria-hidden="true"></i></span>&nbsp;&nbsp; Can be easily moulded into the desired shape.
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    </li>
 
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But we soon found that PVC was not the ideal candidate for our project as PVC is a carcinogen and its use in a product that comes in such close contact with a food will undoubtedly raise health and safety issues.  So we started looking for alternatives to PVC. We soon came upon polycaprolactone. Even though PCL was not the ideal alternative as long as the cost was concerned, it had several properties that were very desirable for our project.
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    <li><span><i class="fa fa-caret-right" aria-hidden="true"></i></span>&nbsp;&nbsp; It is biodegradable. </li>
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    <li><span><i class="fa fa-caret-right" aria-hidden="true"></i></span>&nbsp;&nbsp; <i>Bacillus subtilis</i> cannot degrade it. This means that our sachet cannot be accidentally degraded from the inside. </li>
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    <li><span><i class="fa fa-caret-right" aria-hidden="true"></i></span>&nbsp;&nbsp; Easily available(though costly).</li>
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    <li><span><i class="fa fa-caret-right" aria-hidden="true"></i></span>&nbsp;&nbsp; Nontoxic.</li>   
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So PCL became the material for our inner membrane. For the outer membrane, we selected dialysis membrane, since we need only the AMPs (around 1kDa) to pass through the outer membrane. Soon, we started to search for alternatives to dialysis membrane and we thought that a silk nanofibre filter made a good choice. This was because silk nanofibre filters are completely biodegradable and come with pore sizes as small as 1nm diameter. But we kept this idea on a hold because of the difficulty in procuring these filters and the possible high cost associated with them.
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Then we found out the approximate cost for sachets of four different sizes and made rough estimate.
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We created a Business Model Canvas for our project.
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<h2>Cost of System for different sizes of Membrane</h2>
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    <th>Size (in cm)</th>
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    <th>Inner membrane* INR</th>
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    <th>Outer membrane* INR</th>
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    <th>Growth medium* INR</th>
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    <th>The bacteria and the genetic engineering involved* INR</th>
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    <th>Assembly cost* INR</th>
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    <th>Total* INR</th>
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    <th>Total* $</th>
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    <th>Total* €</th>       
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    <td>4 x 3</td>
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    <td>30</td>
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    <td>16.8</td>
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    <td>1.8</td>
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    <td>10</td>
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    <td>2</td>
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    <td>60.6</td>
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    <td>0.91</td>
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    <td>0.83</td>       
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    <td>5 x 4</td>
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    <td>90</td>
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    <td>28</td>
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    <td>3.6</td>
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    <td>15</td>
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    <td>2</td>
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    <td>138.6</td>
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    <td>2.08</td>
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    <td>1.89</td>       
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    <td>6 x 5</td>
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    <td>170</td>
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    <td>42</td>
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    <td>6</td>
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    <td>20</td>
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    <td>2</td>
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    <td>240</td>
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    <td>3.60</td>
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    <td>3.28</td>       
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    <td>8 x 6</td>
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    <td>320</td>
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    <td>67.2</td>
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    <td>12</td>
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    <td>25</td>
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    <td>2</td>
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    <td>426.2</td>
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    <td>6.39</td>
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    <td>5.82</td>       
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Biodegradability and Mechanical Properties of Polycaprolactone composites encapsulating phosphate-solubilizing bacterium Bacillus PG01-Ken-Jer Wu, Chin-San Wu,Jo-Shu Chang-PROCESS BIOCHEMISTRY April 2007.
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{{SVCE_CHENNAI/sponsors}}

Latest revision as of 07:00, 30 November 2016

Lactoshield - SVCE_CHENNAI Lactoshield - SVCE_CHENNAI

Lactoshield - SVCE_CHENNAI Lactoshield - SVCE_CHENNAI

Entrepreunership

Business Model Canvas

Having interacted with Paskey diary farms and Vijaya milk industries earlier , and modifying our project such that AMPs were produced upon being added to milk by placing them under the regulation of a lac operon, so that on an industrial scale our system could be used to prolong the shelf life of milk, and presenting our business model to them we were awarded Rs.20000 by Paskey farms and 15000 by Vijaya milk industries.

As you might have seen before, the Lactoshield consists of two membranes, an inner and an outer membrane.We initially selected PVC as the material for the inner membrane.

The properties of PVC that we found desirable were:

  •    Low cost.
  •    Easily breakable.
  •    Can be easily moulded into the desired shape.

But we soon found that PVC was not the ideal candidate for our project as PVC is a carcinogen and its use in a product that comes in such close contact with a food will undoubtedly raise health and safety issues. So we started looking for alternatives to PVC. We soon came upon polycaprolactone. Even though PCL was not the ideal alternative as long as the cost was concerned, it had several properties that were very desirable for our project.

  •    It is biodegradable.
  •    Bacillus subtilis cannot degrade it. This means that our sachet cannot be accidentally degraded from the inside.
  •    Easily available(though costly).
  •    Nontoxic.

So PCL became the material for our inner membrane. For the outer membrane, we selected dialysis membrane, since we need only the AMPs (around 1kDa) to pass through the outer membrane. Soon, we started to search for alternatives to dialysis membrane and we thought that a silk nanofibre filter made a good choice. This was because silk nanofibre filters are completely biodegradable and come with pore sizes as small as 1nm diameter. But we kept this idea on a hold because of the difficulty in procuring these filters and the possible high cost associated with them.

Then we found out the approximate cost for sachets of four different sizes and made rough estimate. We created a Business Model Canvas for our project.

Cost of System for different sizes of Membrane

Size (in cm) Inner membrane* INR Outer membrane* INR Growth medium* INR The bacteria and the genetic engineering involved* INR Assembly cost* INR Total* INR Total* $ Total* €
4 x 3 30 16.8 1.8 10 2 60.6 0.91 0.83
5 x 4 90 28 3.6 15 2 138.6 2.08 1.89
6 x 5 170 42 6 20 2 240 3.60 3.28
8 x 6 320 67.2 12 25 2 426.2 6.39 5.82

References

Biodegradability and Mechanical Properties of Polycaprolactone composites encapsulating phosphate-solubilizing bacterium Bacillus PG01-Ken-Jer Wu, Chin-San Wu,Jo-Shu Chang-PROCESS BIOCHEMISTRY April 2007.

Lactoshield - SVCE_CHENNAI Lactoshield - SVCE_CHENNAI
Lactoshield - SVCE_CHENNAI

Sponsors

igemsvce@gmail.com

Sri Venkateswara College of Engineering
Tamil Nadu, India

    

Find us here