Team:Stanford-Brown/SB16 Practices Exploration

Exploration

As part of our summer experience, we went on plenty of adventures and met cool people! EteRNA Conference, Hackathon, BioCurious (http://biocurious.org/), Escape Room, etc.

EteRNA

A lot of the work for Biosensing went into the design of our functional oligonucleotides. We experimented with many secondary and tertiary folding softwares to predict their affinity for molecules in binding pockets, but after consulting experts like Christina Smolke, we eventually determined that was not enough. We sought out crowd-sourcing as a means to optimize our aptamer designs. eteRNA is an interactive platform created by Stanford and Carnegie Mellon University that essentially turns RNA folding into a game. We participated in the eteRNA Convention on July 16th-17th at the Li Ka Shing Center at Stanford. Mike got quite into the game and is now ranked top 1000 in the world! Check out this example of the IRE-mediated translation biosensor and see if you can meet the thermodynamic constraints of -11.7 kcal/mol necessary for proper folding of the Theophylline aptamer! Link: http://www.eternagame.org/web/puzzle/7340069/

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