Difference between revisions of "Team:MIT/Diagnosis and Future Implications"
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<title>Diagnosis and Future Implications </title> | <title>Diagnosis and Future Implications </title> | ||
| + | <h1 style="color:#f20253; text-align: center; font-size: 40px; line-height: 40px;">Future Work & Design</h1> | ||
| + | <h2 style="text-decoration: bold; font-family: Trebuchet MS; color: black; text-align: center;">There is vast, untapped potential for mammalian synthetic biology in medicine; <br>our project is only one example of that. Having characterized a toolkit of mammalian parts <br> | ||
| + | that could be applied to a diagnostic circuit for endometriosis, we designed a full circuit <br> | ||
| + | and tested its logic step-by-step in both hormone phases and disease vs. healthy state. We've <br> | ||
| + | also considered an ideal clinical situation, which we see as a possibility after more thorough<br> | ||
| + | testing of our work, and finally a broader view on the applications of mammalian synbio in medicine. </h2> | ||
| − | < | + | <ul class="img-home"> |
| − | < | + | <li> |
| + | <a href="https://2016.igem.org/Team:MIT/Genetic_Circuit"> | ||
| + | <img src="https://static.igem.org/mediawiki/2016/9/91/T--MIT--FutureCircuit.svg" alt="Genetic Circuit"> | ||
| + | <span class="text-content"><span><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>Read more about our genetic circuit<br><br></span> | ||
| + | </a> | ||
| + | </li> | ||
| + | <li> | ||
| + | <a href="https://2016.igem.org/Team:MIT/Clinical_Applications"> | ||
| + | <img src="https://static.igem.org/mediawiki/2016/d/d0/T--MIT--Future_Clinic.svg" alt="Clinical Applications" width="950px"> | ||
| + | <span class="text-content"><span><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>Read more about applications of mammalian synbio in medicine<br><br></span> | ||
| + | </a> | ||
| + | </li> | ||
| + | </ul> | ||
| + | |||
| + | <br><br><a href="https://2016.igem.org/Team:MIT"><h1 style="color:#ffffff; background-color:#F20253;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS">Back to Home</h1> </a> | ||
| + | <!-- | ||
| + | First section | ||
<h1 style="color:#000000; background-color:#7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Developing a diagnosis</h1> | <h1 style="color:#000000; background-color:#7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Developing a diagnosis</h1> | ||
<p style="font-family: Verdana; float:left;"> Endometriosis is a complex disease – any diagnostic needs to account for a variety of factors. We opted for a three-pronged approach, sensing progesterone resistance and miRNA dysfunction while maintaining temporal specificity. Each of these components represents a key hallmark of the disease, and when put together can create a sensitive diagnostic tool. </p> | <p style="font-family: Verdana; float:left;"> Endometriosis is a complex disease – any diagnostic needs to account for a variety of factors. We opted for a three-pronged approach, sensing progesterone resistance and miRNA dysfunction while maintaining temporal specificity. Each of these components represents a key hallmark of the disease, and when put together can create a sensitive diagnostic tool. </p> | ||
| − | + | Second section | |
<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> A Proposed Genetic Circuit </h1> | <h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> A Proposed Genetic Circuit </h1> | ||
<p style="font-family:Verdana;"> | <p style="font-family:Verdana;"> | ||
There should be a circuit diagram or flow-chart here, along with an explanation of how it works. | There should be a circuit diagram or flow-chart here, along with an explanation of how it works. | ||
| + | https://2016.igem.org/Team:MIT/Genetic_Circuit | ||
</p> | </p> | ||
| − | + | Third section | |
<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Implementing a Diagnosis </h1> | <h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Implementing a Diagnosis </h1> | ||
<p style = "font-family:Verdana;"> | <p style = "font-family:Verdana;"> | ||
We initially contemplated creating an in-vivo diagnostic, but changed our minds after speaking with Professor Linda Griffith (MIT). Realistically, inserting a genetic circuit into a human (likely through the use of a viral vector) is many years away from being a possibility due to major safety concerns. Implementing an in-vitro diagnostic that can be used on an endometrial biopsy is more feasible. An endometrial biopsy is a procedure that can be done in a doctor’s office without anesthesia and is commonly used when testing for endometrial cancer. While not a pain-free procedure, endometrial biopsies are considerably less invasive than laparoscopic surgery, the current diagnostic method for endometriosis. The tissue from the biopsy can be dosed with hormones.... TALK MORE ABOUT THIS, UNSURE OF SPECIFICS. | We initially contemplated creating an in-vivo diagnostic, but changed our minds after speaking with Professor Linda Griffith (MIT). Realistically, inserting a genetic circuit into a human (likely through the use of a viral vector) is many years away from being a possibility due to major safety concerns. Implementing an in-vitro diagnostic that can be used on an endometrial biopsy is more feasible. An endometrial biopsy is a procedure that can be done in a doctor’s office without anesthesia and is commonly used when testing for endometrial cancer. While not a pain-free procedure, endometrial biopsies are considerably less invasive than laparoscopic surgery, the current diagnostic method for endometriosis. The tissue from the biopsy can be dosed with hormones.... TALK MORE ABOUT THIS, UNSURE OF SPECIFICS. | ||
| + | https://2016.igem.org/Team:MIT/Clinical_Applications | ||
</p> | </p> | ||
| − | + | Fourth section | |
<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Synthetic Biology & Medicine - How SynBio Approaches Can Transform Diagnostics </h1> | <h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Synthetic Biology & Medicine - How SynBio Approaches Can Transform Diagnostics </h1> | ||
<p style = "font-family:Verdana;"> | <p style = "font-family:Verdana;"> | ||
Our approach of using a genetic circuit to sense diseased cells presents possibilities beyond endometriosis. Similar strategies can be used to diagnose other diseases... KEEP GOING WITH THIS | Our approach of using a genetic circuit to sense diseased cells presents possibilities beyond endometriosis. Similar strategies can be used to diagnose other diseases... KEEP GOING WITH THIS | ||
| + | https://2016.igem.org/Team:MIT/Clinical_Applications | ||
</p> | </p> | ||
</body> | </body> | ||
| + | --> | ||
</html> | </html> | ||
Latest revision as of 23:46, 19 October 2016
