Difference between revisions of "Team:MIT/Diagnosis and Future Implications"

 
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that could be applied to a diagnostic circuit for endometriosis, we designed a full circuit <br>
 
that could be applied to a diagnostic circuit for endometriosis, we designed a full circuit <br>
 
and tested its logic step-by-step in both hormone phases and disease vs. healthy state. We've <br>
 
and tested its logic step-by-step in both hormone phases and disease vs. healthy state. We've <br>
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also considered an ideal clinical situation, what we consider a possibility after more thorough<br>
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also considered an ideal clinical situation, which we see as a possibility after more thorough<br>
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testing of our work, and a broader view on the applications of mammalian synbio in medicine. </h2>
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testing of our work, and finally a broader view on the applications of mammalian synbio in medicine. </h2>
  
 
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<br><br><a href="https://2016.igem.org/Team:MIT"><h1 style="color:#ffffff; background-color:#F20253;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS">Back to Home</h1> </a>
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<h1 style="color:#000000; background-color:#7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Developing a diagnosis</h1>   
 
<h1 style="color:#000000; background-color:#7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Developing a diagnosis</h1>   
  
 
<p style="font-family: Verdana; float:left;"> Endometriosis is a complex disease – any diagnostic needs to account for a variety of factors. We opted for a three-pronged approach, sensing progesterone resistance and miRNA dysfunction while maintaining temporal specificity. Each of these components represents a key hallmark of the disease, and when put together can create a sensitive diagnostic tool. </p>
 
<p style="font-family: Verdana; float:left;"> Endometriosis is a complex disease – any diagnostic needs to account for a variety of factors. We opted for a three-pronged approach, sensing progesterone resistance and miRNA dysfunction while maintaining temporal specificity. Each of these components represents a key hallmark of the disease, and when put together can create a sensitive diagnostic tool. </p>
  
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<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> A Proposed Genetic Circuit </h1>   
 
<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> A Proposed Genetic Circuit </h1>   
  
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<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Implementing a Diagnosis </h1>
 
<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Implementing a Diagnosis </h1>
  
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<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Synthetic Biology & Medicine - How SynBio Approaches Can Transform Diagnostics </h1>   
 
<h1 style="color:#000000; background-color: #7ecefd;; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> Synthetic Biology & Medicine - How SynBio Approaches Can Transform Diagnostics </h1>   
 
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Latest revision as of 23:46, 19 October 2016

Diagnosis and Future Implications

Future Work & Design

There is vast, untapped potential for mammalian synthetic biology in medicine;
our project is only one example of that. Having characterized a toolkit of mammalian parts
that could be applied to a diagnostic circuit for endometriosis, we designed a full circuit
and tested its logic step-by-step in both hormone phases and disease vs. healthy state. We've
also considered an ideal clinical situation, which we see as a possibility after more thorough
testing of our work, and finally a broader view on the applications of mammalian synbio in medicine.



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