Difference between revisions of "Team:SJTU-BioX-Shanghai"

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            <span dir="auto">Team:SJTU-BioX-Shanghai</span>
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<li> <a href="https://2016.igem.org/Team:SJTU-BioX-Shanghai/Human_Practices/Hospital_Experiencing">Hospital Experiencing</a></li>
 
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<h1><span class="mw-headline">Motivation</span></h1>
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<h1><span class="mw-headline">Design</span></h1>
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<h2><span class="mw-headline">The Situation</span></h2>
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<ul><li> Design as a whole</li>
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<li>Yeast glucose sensor</li>
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<li>Yeast biosensor as freeze-dried powders</li>
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<li>Vision for the future</li></ul>
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<p><a href="/File:SJTUB_home3.jpg" class="image" title="float = left"><img alt="float = left" src="/wiki/images/2/22/T--SJTU-BioX-Shanghai--team2016_logo.JPG" width="310" height="192" /></a>
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<p><a href="/File:SJTUB_home3.jpg" class="image" title="float = left"><img alt="float = left" src="/wiki/images/2/22/T--SJTU-BioX-Shanghai--team2016_logo.JPG" width="310" height="192" srcset="/wiki/images/2/20/SJTUB_home3.jpg 1.5x, /wiki/images/2/20/SJTUB_home3.jpg 2x" /></a>
 
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<p class="main-page">Nowadays, health problem has become rather severe in China. In 2015, there are approximately 92.4 million people of diabetes, 170 million people of hypertension and 4.3 million newly added cancer cases in China according to the Chinese Health Big Data (http://www.yx129.com/yxqy/6176.html). On average, every 30 seconds, one man dies of cardio cerebral vascular diseases here in China. What’s worse, the age of morbidity crowd displays a younger trend due to unhealthy lifestyle.
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<h2><span class="mw-headline">Problems in medical service</span></h2>
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<p class="main-page">Chinese people now are facing serious problems to go to see a doctor and get medical help. There are tremendous gaps between municipal-level hospitals and grass-rooted ones. Large hospitals in cities always have clean floors, advanced medical instruments and experienced doctors, while small hospitals are lack of these, especially outstanding doctors[1]. Consequently, municipal hospitals are always crowded of people. Citizens have to queue for a long time to get medical help. Moreover, the cost of medical service and medicine remains a problem.
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<p class="main-page">As a result, many people refuse to go to the hospital, unless they feel there’s something wrong with their physical condition, let alone physical test. In fact, physical examination has become a dilemma. On one hand, the public want to know whether they are healthy, on the other hand, they worry about the cost [2].
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<p><a href="/File:SJTUB_home2.jpg" class="image" title="float = right"><img alt="float = right" src="/wiki/images/2/22/T--SJTU-BioX-Shanghai--team2016_logo.JPG" width="310" height="230" srcset="/wiki/images/thumb/3/3a/SJTUB_home2.jpg/465px-SJTUB_home2.jpg 1.5x, /wiki/images/thumb/3/3a/SJTUB_home2.jpg/620px-SJTUB_home2.jpg 2x" /></a>
 
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<p class="main-page">In fact, many diseases can be prevented by encouraging more people to do physical examinations to prevent or treat diseases in the first place. However, doing physical examinations is still not very convenient. In urban areas in China, as the same in many other places in the world, physical examination is quite a time-consuming event, usually taking a whole day to accomplish and a whole week to wait for the results, which bothers busy office workers in China a lot, resulting in their low participation in physical examinations. In suburbs, especially in many poverty-stricken mountain areas in the west of China, local residents are inaccessible to take physical examinations due to the crude medical conditions and the high cost of examinations.
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<p class="main-page">See more of this part in HP medical service.
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<h2><span class="mw-headline">Importance of early diagnosis</span></h2>
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<h2><span class="mw-headline">Our thoughts</span></h2>
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<p class="main-page">Early diagnosis plays a critical role in cancer treatment. In China, there are 1.6 billion people died from cancer every year. Cancer has become No.1 which causes most municipal patients die. But an amazing portion of 80%~90% patients can recover if they get early treatment[3]. Consequently, early diagnosis should be attached importance to.
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<p class="main-page">We managed to engineer Saccharomyces cerevisiae, a yeast strain with great abundance of background information and simple genetic manipulations, to make it a promising choice for individual to make early diagnosis domestically. The most exciting part of our story is that our yeast biosensor can not only serve as a chassis for an incredibly large variety of disease biomarkers but also response in a real-time manner which allows users to get their results within 10 minutes.
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<p class="main-page">We went to two municipal hospitals in Shanghai (Ruijin Hospital and No.9 Hospital) and one community hospital in Guizhou Province. At the registration office, we see a long queue. But for the community hospital in Guizhou Province, few people were seen there. The hall of Ruijin Hospital is clean and bright, while that of the community hospital is obviously darker.
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<p class="main-page">We interviewed some patients at Ruijin Hospital. Most of them said they felt it hard to get medical help. They have to wait for a long time to see a doctor. Moreover, it’s expensive to take medical treatment. When we asked about physical test, they said they often did it.
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<p class="main-page">In case of these reasons mentioned above, we came up with our project, hoping to help people get early diagnosis for certain disease. Because it’s not convenient and expensive to get medical treatment, we will make our product a domestic one and make it very cheap to use.
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<h2><span class="mw-headline" id="Reference">Reference</span></h2>
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<p><i>[1] Zhen C., et al. Current Situation of Public Hospital at Grass-roots level and Countermeasures in Health Care Reform, Contemporary Medicine. 2016, Vol.22 No.13 Issue No.420</i></p>
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<p><i>[2] Proposals on Deepening the Reform of Medical System. General Office of the State Council of the People's Republic of China (GOSSC), 2009</i></p>
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<p><i>[3] General situation of cancer of People’s Republic of China in 2015. The people's Republic of China National Healthand Family Planning Commission (NHFPC), 2015.</i></p>
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Revision as of 12:25, 15 October 2016

Team:SJTU-BioX-Shanghai - 2016.igem.org

Team:SJTU-BioX-Shanghai







The Situation

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Nowadays, health problem has become rather severe in China. In 2015, there are approximately 92.4 million people of diabetes, 170 million people of hypertension and 4.3 million newly added cancer cases in China according to the Chinese Health Big Data (http://www.yx129.com/yxqy/6176.html). On average, every 30 seconds, one man dies of cardio cerebral vascular diseases here in China. What’s worse, the age of morbidity crowd displays a younger trend due to unhealthy lifestyle.



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In fact, many diseases can be prevented by encouraging more people to do physical examinations to prevent or treat diseases in the first place. However, doing physical examinations is still not very convenient. In urban areas in China, as the same in many other places in the world, physical examination is quite a time-consuming event, usually taking a whole day to accomplish and a whole week to wait for the results, which bothers busy office workers in China a lot, resulting in their low participation in physical examinations. In suburbs, especially in many poverty-stricken mountain areas in the west of China, local residents are inaccessible to take physical examinations due to the crude medical conditions and the high cost of examinations.





Our thoughts

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We managed to engineer Saccharomyces cerevisiae, a yeast strain with great abundance of background information and simple genetic manipulations, to make it a promising choice for individual to make early diagnosis domestically. The most exciting part of our story is that our yeast biosensor can not only serve as a chassis for an incredibly large variety of disease biomarkers but also response in a real-time manner which allows users to get their results within 10 minutes.




Bio-X Institutes

Shanghai Jiao Tong University

800, Dongchuan Road 200240, Shanghai, China

xxxxxxxxx@sjtu.edu.cn