Difference between revisions of "Team:MIT"

 
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     <a href="https://2016.igem.org/Team:MIT/Description">
 
     <a href="https://2016.igem.org/Team:MIT/Description">
 
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       <span class="text-content"><span><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>Read more about endometriosis<br><br></span>
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       <span class="text-content"><span><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>Read more about endometriosis and our project design<br><br></span>
 
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     <a href="https://2016.igem.org/Team:MIT/Experiments/miRNA">
 
     <a href="https://2016.igem.org/Team:MIT/Experiments/miRNA">
 
       <img src="https://static.igem.org/mediawiki/2016/8/89/T--MIT--miRNAsensorsbutton.svg" alt="miRNA" >
 
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       <span class="text-content"><span><br><br><br><br><br><br><br>We characterized miRNA profiles in model cells under varying conditions<br><br></span></span>
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       <span class="text-content"><span><br><br><br><br><br><br><br>We characterized microRNA profiles in model cells under varying conditions<br><br></span></span>
 
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     <a href="https://2016.igem.org/Team:MIT/Experiments/Promoters/Experiment-Details-for-Cascades">
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     <a href="https://2016.igem.org/Team:MIT/Proof">
 
       <img src="https://static.igem.org/mediawiki/2016/8/80/T--MIT--CascadeButton.svg" alt="Parts cascade" >
 
       <img src="https://static.igem.org/mediawiki/2016/8/80/T--MIT--CascadeButton.svg" alt="Parts cascade" >
 
       <span class="text-content"><span><br><br><br><br><br><br><br>Read about a summary of our results and how our sensors interact logically after transfection of <br>4 to 5-unit genetic circuits into model cell cultures<br><br></span></span>
 
       <span class="text-content"><span><br><br><br><br><br><br><br>Read about a summary of our results and how our sensors interact logically after transfection of <br>4 to 5-unit genetic circuits into model cell cultures<br><br></span></span>
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  <a href="https://2016.igem.org/Team:MIT/Attributions">
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      <span class="text-content"><span><br><br><br><br><br><br><br><br>Read more<br><br></span></span>
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<!-- <h2>Genetic circuit to sense endometriosis</h2>
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<p>Some of our team's achievements this year include:</p>
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<li>Developed <b>novel estrogen and progesterone inducible synthetic mammalian promoters</b> through bottom-up promoter engineering. These constructs could resolve the changes in estrogen and progesterone signaling characteristic of endometriosis</li>
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<li>Characterized the <b>functionality of a miRNA sensing platform in TERT immortalized human endometrial stromal cells (tHESC)</b>. We are one of the first to characterize changes in miRNA activity in the cell line with and without estrogen. </li>
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<li>Characterized <b> the functionality of a serine integrase (TP901) in a mammalian cell line</b>. Recombinases like TP901 downstream of a <b>tunable L7Ae - kturn system that we implemented</b> could help process input from our estrogen, progesterone, and miRNA sensors and adjust output as per a patient's needs. </li>
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<li>Transfected <a href="https://2016.igem.org/Team:MIT/Experiments/Promoters/Experiment-Details-for-Cascades"><b>larger 4 to 5 transcriptional unit genetic circuits that cascaded our devices together</b></a> in order to explore how our sensors interact with one another.</li>
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<a href="https://2016.igem.org/Team:MIT/Description"><img src="https://static.igem.org/mediawiki/2016/0/07/T--MIT--BackgroundButton.svg" style="width:225px;height:225px;"></a><a href="https://2016.igem.org/Team:MIT/Experiments"><img src="https://static.igem.org/mediawiki/2016/0/09/T--MIT--ExperimentsButton3.svg" style="width:225px;height:225px;"></a>
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<a href="https://2016.igem.org/Team:MIT/Medals"><img src="https://static.igem.org/mediawiki/2016/6/6e/T--MIT--MedalsButton2.svg" style="width:225px;height=225px;"></a><a href="https://2016.igem.org/Team:MIT/Judge"><img src="https://static.igem.org/mediawiki/2016/5/57/T--MIT--JudgingButton.svg" style="width:225px;height=225px;"></a><a href="https://2016.igem.org/Team:MIT/Human_Practices"><img src="https://static.igem.org/mediawiki/2016/8/86/T--MIT--HPButton.svg" / style="width:225px;height=225px;"></a><br>
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Latest revision as of 19:05, 18 October 2016