Difference between revisions of "Team:LMU-TUM Munich"
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<li class="sponsor">[[Image:Muc16_Sponsor_ChemieTUM.png|link=http://www.ch.tum.de/|alt=Department Chemie der TUM]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_ChemieTUM.png|link=http://www.ch.tum.de/|alt=Department Chemie der TUM]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_BioM.png|link=http://www.bio-m.org|alt=Bio M]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_BioM.png|link=http://www.bio-m.org|alt=Bio M]]</li> | ||
| − | <li class="sponsor">[[Image: | + | <li class="sponsor">[[Image:Muc16_Sponsor_XLprotein.tif|link=http://xl-protein.com/|alt=XL protein]]</li> |
| + | <li class="sponsor">[[Image:Muc16_Sponsor_Promega.png|link=http://www.promega.de/|alt=Promega]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_Promega.png|link=http://www.promega.de/|alt=Promega]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Promega.png|link=http://www.promega.de/|alt=Promega]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_IDT.png|link=http://www.idt-DNA.com|alt=Integrated DNA Technilogies]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_IDT.png|link=http://www.idt-DNA.com|alt=Integrated DNA Technilogies]]</li> | ||
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| + | [Image:Muc16_Sponsor_XLprotein.tif] | ||
{{LMU-TUM_Munich_html_end}} | {{LMU-TUM_Munich_html_end}} | ||
Revision as of 17:31, 30 November 2016
Abstract: biotINK - rethINK tissue printing
We are living in an aging society that is facing a decreasing supply of donor organs. To confront this pressing issue, we developed a game-changing approach to bioprint tissues for biomedical applications. Our interdisciplinary work aims to create a unique ink, named biotINK, to revolutionize bioprinting. The printing process uses a hijacked 3D printer and two components of biotINK to induce an instantaneous polymerization reaction, creating three-dimensional multi-cellular structures in a user-definable manner. The principle of this two-component glue relies on the rapid and specific interaction of biotin and its tetrameric binding protein avidin. To make use of this high biotin-avidin affinity for cell-cell cross-linking, we engineered cells presenting biotin moieties or biotin-binding proteins on their surfaces as well as recombinant matrix proteins, which co-polymerize upon printing. Furthermore, we explored different genetic circuits which allow us to functionalize the bio-synthetic tissue and install biosafety mechanisms.
Altogether, we are confident that our system provides the necessary means to advance the SynBio community to the next level – the tissue level.
Sponsors
[Image:Muc16_Sponsor_XLprotein.tif]
